Objective:

2

To investigate the distribution of Chinese medicine (CM) syndrome in patients with acute myocardial infarction (AMI) on admission and its impact on prognosis.

Methods:

2

A total of 525 AMI patients were prospectively recruited and classified into 4 groups based on their clinical characteristics: excess-heat

excess-cold

deficiency-heat and deficiency-cold syndromes. Major adverse cardiovascular events (MACEs) were followed up.

Results:

2

The excess syndrome was more common than deficiency syndrome (72.95% vs. 27.05%;

P

<

0.05). Totally 495 (94.29%) of 525 AMI patients were followed up (median 277 days). There were 59 (11.92%) MACEs. After adjusted with confounding factors in Cox regression models

the hazard ratio (95% confidence interval) of excess-heat

excess-cold

deficiency-heat and deficiency-cold syndrome groups were 1

1.25 (0.63

2.49;

P

<

0.05)

2.37 (1.14

4.94;

P

<

0.05)

3.76 (1.71

8.28;

P

<

0.05)

respectively.

Conclusions:

2

Excess syndrome was more common in AMI patients and had better prognosis

while deficiency-cold syndrome had the poorest prognosis. CM syndrome was of value in predicting long-term outcomes in AMI patients.