Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice

Hyo Won Jung; Kyung-Ho Kim; Yong-Ki Park

doi:10.1007/s11655-016-2094-5

Your Location：

Home >

Browse articles >

Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice

Updated：2021-08-27

- Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice
- Chinese Journal of Integrative Medicine Vol. 23, Issue 10, Pages: 755-762(2017)
- Affiliations：
  
  1. Department of Herbology, College of Korean Medicine, Dongguk University, Gyeongju, Republic of Korea
  2. Korean Medicine Research and Development Center, Dongguk University, Gyeongju, Republic of Korea
  3. Department of Acupuncture, College of Korean Medicine, Dongguk University, Gyeongju, Republic of Korea
- Author bio：
- Funds：
- DOI：10.1007/s11655-016-2094-5
  CLC：
- Published：2017，
  
  Published Online：26 July 2016，
Scan for full text
Jung, H.W., Kim, KH. & Park, YK. Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice., Chin. J. Integr. Med. 23, 755–762 (2017). https://doi.org/10.1007/s11655-016-2094-5

Hyo Won Jung, Kyung-Ho Kim, Yong-Ki Park. Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice. [J]. Chinese Journal of Integrative Medicine 23(10):755-762(2017)
Jung, H.W., Kim, KH. & Park, YK. Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice., Chin. J. Integr. Med. 23, 755–762 (2017). https://doi.org/10.1007/s11655-016-2094-5 DOI：

Hyo Won Jung, Kyung-Ho Kim, Yong-Ki Park. Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice. [J]. Chinese Journal of Integrative Medicine 23(10):755-762(2017) DOI： 10.1007/s11655-016-2094-5.

摘要

To investigate whether the dried root of Phellodendron amurense Ruprecht (Phellodendri cortex; PC) extract improves arthritic symptoms through anti-inflammatory and immune-modulatory effects in collagen-induced arthritis in mice. Rheumatoid arthritis (RA) was induced in male DBA/1 mice by immunization with type II collagen (ColII). CIA mice were divided into 5 groups (n=10 per a group) with normal

CIA control

PC extract (50 mg/kg and 100 mg/kg)-treated

and meloxicam (50 mg/kg)-treated as the reference drug. The PC extract or meloxicam were administered orally in CIA mice once a day for 14 days after arthritis induction. Arthritic score

levels of anti-ColII IgG2a antibody

prostaglandin E2 (PGE2)

tumor necrosis factor (TNF)-α

and interleukin (IL)-17 in the sera of CIA mice were measured. Histopathological changes in the ankle joints of CIA mice were also analyzed by staining with hematoxylin and eosin (H and E)

safranin-O and immunohistochemistry using anti-TNF-α and anti-IL-17 antibodies. The arthritic score was increased in CIA mice in a time-dependent manner

as were the serum levels of anti-ColII IgG2a antibody

PGE2

TNF-α

and IL-17. However

the oral administration of PC extract at 50 and 100 mg/kg in CIA mice significantly decreased the arthritic scores

and the serum levels of anti-ColII IgG2a

PGE2

TNF-α

and IL-17 compared with those in the CIA group (P<0.05 or P<0.01). Furthermore

histopathological improvement of the joint architecture in CIA mice was observed after administration of PC extract. PC extract also significantly inhibited the expression of TNF-α and IL-17 in the joints of CIA mice by suppressing the expression of their mRNA and proteins. PC extract may improve the pathological progression of RA through the inhibition of joint destruction by synovial inflammation and immune-stimulation

therefore

it would be a potential anti-arthritic agent in RA.

Abstract

CIA control

PC extract (50 mg/kg and 100 mg/kg)-treated

and meloxicam (50 mg/kg)-treated as the reference drug. The PC extract or meloxicam were administered orally in CIA mice once a day for 14 days after arthritis induction. Arthritic score

levels of anti-ColII IgG2a antibody

prostaglandin E2 (PGE2)

tumor necrosis factor (TNF)-α

and interleukin (IL)-17 in the sera of CIA mice were measured. Histopathological changes in the ankle joints of CIA mice were also analyzed by staining with hematoxylin and eosin (H and E)

safranin-O and immunohistochemistry using anti-TNF-α and anti-IL-17 antibodies. The arthritic score was increased in CIA mice in a time-dependent manner

as were the serum levels of anti-ColII IgG2a antibody

PGE2

TNF-α

and IL-17. However

the oral administration of PC extract at 50 and 100 mg/kg in CIA mice significantly decreased the arthritic scores

and the serum levels of anti-ColII IgG2a

PGE2

TNF-α

and IL-17 compared with those in the CIA group (P<0.05 or P<0.01). Furthermore

therefore

it would be a potential anti-arthritic agent in RA.

关键词

Phellodendron amurensePhellodendri cortexcollagen-induced arthritisanti-arthritic effect

Keywords

Phellodendron amurensePhellodendri cortexcollagen-induced arthritisanti-arthritic effect

references

Brand DD, Kang AH, Rosloniec EF. Immunopathogenesis of collagen arthritis. Springer Sem Immunopathol 2003;25:3–18.

Chabaud M, Durand JM, Buchs N, Fossiez F, Page G, Frappart L, et al. Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum 1999;42:963–970.

McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 2007;7:429–442.

Gao XZ, Komai-Koma M, Leung BP, Howe HS, McSharry C, McInnes IB, et al. Resveratrol modulates murine collageninduced arthritis by inhibiting Th17 and B-cell function. Ann Rheum Dis 2012;71:129–135.

Efthimiou P, Kukar M. Complementary and alternative medicine use in rheumatoid arthritis: proposed mechanism of action and efficacy of commonly used modalities. Rheumatol Int 2010;30:571–586.

Callahan LF, Wiley-Exley EK, Mielenz TJ, Brady TJ, Xiao C, Currey SS, et al. Use of complementary and alternative medicine among patients with arthritis. Prevent Chronic Dis 2004;6:A44.

Yen CH, ed. The pharmacology of Chinese herbs. 1st ed. Taipei: Chin-Yin Publishing;1999:376–377.

Zhang Q, Zhang Q, Cai L, Zhong G, Luo W. Simultaneous determination of jatrorrhizine, palmatine, berberine, and obacunone in Phellodendri Amurensis Cortex by PR-HPLC. China J Chin Mater Med (Chin) 2010;35:2061–2064.

Uchuyama T, Kamikawa H, Ogita Z. Anti-ulcer effect of extract from Phellodendri cortex. J Pharm Sco Jap (Jpn) 1989;109:672–676.

Park JI, Shim JK, Do JW, Kim SY, Seo EK, Kwon HJ, et al. Immune-stimulating properties of polysaccharides from Phellodendri cortex (Hwangbek). Glycoconj J 1999;16:247–252.

Kong LD, Yang C, Qiu X, Wu HP, Ye DJ. Effects of different processing products of Cortex Phellodendri on scavenging oxygen free radicals and anti-lipidperoxidation. China J Chin Mater Med (Chin) 2001;26:245–248.

Park YK, Chung YS, Kim YS, Kwon OY, Joh TH. Inhibition of gene expression and production of iNOS and TNF-alpha in LPS-stimulated microglia by methanol extract of Phellodendri cortex. Int Immunopharmacol 2007;7:955–962.

Wu YH, Chuang SY, Hong WC, Lai YJ, Chang YL, Pang JH. In vivo and in vitro inhibitory effects of a traditional Chinese formulation on LPS-stimulated leukocyte-endothelial cell adhesion and VCAM-1 gene expression. J Ethnopharmacol 2012;140:55–63.

Mao YF, Li YQ, Zong L, You XM, Lin FQ, Jiang L. Methanol extract of Phellodendri cortex alleviates lipopolysaccharideinduced acute airway inflammation in mice. Immunopharmacol Immunotoxicol 2010;32:110–115.

Xian YF, Mao QQ, Ip SP, Lin ZX, Che CT. Comparison on the anti-nflammatory effect of Cortex Phellodendri Chinensis and Cortex Phemmodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice. J Ethnopharmacol 2011;137:1425–1430.

Hong SJ, Fong JC, Hwang JH. Effects of crude drugs on glucose uptake in 3T3-L1 adipocytes. Kaohsiung J Med Sci 2000;16:445–451.

Kim HJ, Kong MK, Kim YC. Beneficial effects of Phellodendri Cortex extract on hyperglycemia and diabetic nephropathy in streptozotocin-induced diabetic rats. BMB Rep 2008;41:710–715.

Jung HW, Jin GZ, Kim SY, Kim YS, Park YK. Neuroprotective effect of methanol extract of Phellodendri cortex against 1-methyl-4-penylpyridinium (MPP+)-induced apoptosis in PC12 cells. Cell Biol Int 2009;33:957–963.

Cho YG, Cho ML, Min SY, Kim HY. Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis. Autoimm Rev 2007;7:65–70.

Stuart JM, Cremer MA, Kang AH, Townes AS. Collageninduced arthritis in rats: evaluation of early immunologic events. Arthritis Rheum 1979;22:1344–1351.

Brand DD, Latham KA, Rosloniec EF. Collagen-induced arthritis as a model for rheumatoid arthritis. Nature Protocols 2007;2:1269–1275.

Ahmed S, Anuntiyo J, Malemud CJ, Haqqi TM. Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review. Evid Based Complement Alternat Med 2005;2:301–308.

Ahmed M, Khanna D, Furst DE. Meloxicam in rheumatoid arthritis. Expert Opin Drug Metab Toxicol 2005;1:739–751.

Fournier C. Where do T cells stand in rheumatoid arthritis? Joint Bone Spine 2005;72:527–532.

Martel-Pelletier J, Pelletier JP, Fahmi H. Cyclooxygenase-2 and prostaglandins in articular tissues. Semin Arthritis Rheum 2003;33:155–167.

Smolen JS, Redlich K, Zwerina J, Aletaha D, Steiner G, Schett G. Pro-inflammatory cytokines in rheumatoid arthritis: pathogenetic and therapeutic aspects. Clinic Rev Allergy Immunol 2005;28:239–248.

Astry B, Harberts E, Moudgil KD. A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis. J Interferon Cytokine Res 2011;31:927–940.

Stamp LK, James MJ, Cleland LG. Interleukin-17: the missing link between T-cell accumulation and effector cell actions in rheumatoid arthritis. Immunol Cell Biol 2004;82:1–9.

Arend WP, Dayer JM. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthritis Rheum1995;38:151–160.

Venkatesha SH, Berman BM, Moudgil KD. Herbal medicinal products target defined biochemical and molecular mediators of inflammatory autoimmune arthritis. Bioorg Med Chem 2011;19:21–29.

Schnotzer TJ, Hochberg MC. COX-2-selective inhibitors in the treatment of arthritis. Clevelend Clin J Med 2002;69:SI20–S130.

Wang XH, Jiang SM, Sun QW. Effects of berberine on human arthritis fibroblast-like synoviocytes. Exp Biol Med (Maywood) 2011;236:859–866.

Hu Z, Jiao Q, Ding J, Liu F, Liu R, Shan L, et al. Berberine induces dendritic cell apoptosis and has therapeutic potential for rheumatoid arthritis. Arthritis Rheum 2011;63:949–959.

FULL TEXT LINK

More>

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Effect of wenhua juanbi recipe (温化蠲痹方) on proliferation and apoptosis of synoviocytes in rats with collagen-inducing arthritis

Effect of Qubi Zhentong Recipe (祛痹镇痛方) on synovial gene expression in collagen-induced arthritis in rats

Effect of Wenhua Juanbi Recipe (温化蠲痹方) on expression of receptor activator of nuclear factor kappa B ligand, osteoprotegerin, and tumor necrosis factor receptor superfamily member 14 in rats with collagen-induced arthritis

Effects of agkistrodon in different dosage forms on collagen-induced arthritis in rats

Therapeutic effect of dimethyl dimethoxy biphenyl dicarboxylate on collagen-induced arthritis in rats

Related Author

No data

Related Institution

Department of Arthropathy, Zhejiang Provincial Hospital of Integrated Traditional and Western Medicine

Zhejiang University of Traditional Chinese Medicine

The Fifth People’s Hospital of Yuhang District of Hangzhou

Laboratory of Rheumatoid Immune, The Second Affiliated Hospital of Zhejiang Chinese Medical University

Zhejiang Xinhua Hospital

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰