Effect of Zuogui Pill (左归丸) on monoamine neurotransmitters and sex hormones in climacteric rats with panic attack

Xiao-yu Li; Xiao-yun Wang

doi:10.1007/s11655-016-2095-4

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Effect of Zuogui Pill (左归丸) on monoamine neurotransmitters and sex hormones in climacteric rats with panic attack

Updated：2021-08-27

- Effect of Zuogui Pill (左归丸) on monoamine neurotransmitters and sex hormones in climacteric rats with panic attack
- Chinese Journal of Integrative Medicine Vol. 23, Issue 3, Pages: 190-195(2017)
- Affiliations：
  
  1. Department of Gynecologic, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,China
  2. Post-doctoral Research Center of Guangzhou University of Chinese Medicine,Guangzhou,China
- Author bio：
- Funds：
  
  Supported by the Natural Science Foundation of Guangdong Province, China (No. 8151040701000033)
- DOI：10.1007/s11655-016-2095-4
  CLC：
- Published：2017，
  
  Published Online：7 December 2016，
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Li, Xy., Wang, Xy. Effect of Zuogui Pill (左归丸) on monoamine neurotransmitters and sex hormones in climacteric rats with panic attack., Chin. J. Integr. Med. 23, 190–195 (2017). https://doi.org/10.1007/s11655-016-2095-4

Xiao-yu Li, Xiao-yun Wang. Effect of Zuogui Pill (左归丸) on monoamine neurotransmitters and sex hormones in climacteric rats with panic attack. [J]. Chinese Journal of Integrative Medicine 23(3):190-195(2017)
Li, Xy., Wang, Xy. Effect of Zuogui Pill (左归丸) on monoamine neurotransmitters and sex hormones in climacteric rats with panic attack., Chin. J. Integr. Med. 23, 190–195 (2017). https://doi.org/10.1007/s11655-016-2095-4 DOI：

Xiao-yu Li, Xiao-yun Wang. Effect of Zuogui Pill (左归丸) on monoamine neurotransmitters and sex hormones in climacteric rats with panic attack. [J]. Chinese Journal of Integrative Medicine 23(3):190-195(2017) DOI： 10.1007/s11655-016-2095-4.

摘要

To explore the effects of Chinese medicine prescription Zuogui Pill (左归丸

ZGP) on monoamine neurotransmitters and sex hormones in climacteric rats with induced panic attacks. Forty-eight climacteric female rats were randomized into 6 groups with 8 rats in each group: the control group

the model group

the low-

medium- and high-dose ZGP groups and the alprazolam group. Rats in the low-

medium- and high-dose ZGP groups were administered 4.725

9.45

or 18.9 g/kg ZGP by gastric perfusion

respectively. The alprazolam group was treated by gastric perfusion with 0.036 mg/kg alprazolam. The control and model groups were treated with distilled water. The animals were pretreated once daily for 8 consecutive weeks. The behaviors of rats in the open fifield test and the elevated T-maze (ETM) were observed after induced panic attack

and the levels of brain monoamine neurotransmitters and the plasma levels of sex hormones were measured. Compared with the control group

the mean ETM escape time and the levels of 5-hydroxytryptamine (5-HT) and noradrenalin (NE) of the model group were signifificantly reduced (P<0.05)

Compared with the model group

the mean ETM escape time and the 5-HT and NE levels of all the ZGP groups increased signifificantly (P<0.05 or P<0.01). However

no signifificant difference was observed in the levels of sex hormones between the groups. Pretreatment with ZGP in climacteric rats may improve the behavior of panic attack

which may be related to increased 5-HT and NE in the brain.

Abstract

To explore the effects of Chinese medicine prescription Zuogui Pill (左归丸

the model group

the low-

medium- and high-dose ZGP groups and the alprazolam group. Rats in the low-

medium- and high-dose ZGP groups were administered 4.725

9.45

or 18.9 g/kg ZGP by gastric perfusion

and the levels of brain monoamine neurotransmitters and the plasma levels of sex hormones were measured. Compared with the control group

the mean ETM escape time and the levels of 5-hydroxytryptamine (5-HT) and noradrenalin (NE) of the model group were signifificantly reduced (P<0.05)

Compared with the model group

the mean ETM escape time and the 5-HT and NE levels of all the ZGP groups increased signifificantly (P<0.05 or P<0.01). However

no signifificant difference was observed in the levels of sex hormones between the groups. Pretreatment with ZGP in climacteric rats may improve the behavior of panic attack

which may be related to increased 5-HT and NE in the brain.

关键词

Zuogui Pillclimactericpanic attackmonoamine neurotransmittersex hormoneChinese Medicine

Keywords

Zuogui Pillclimactericpanic attackmonoamine neurotransmittersex hormoneChinese Medicine

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