Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B

Yu Zhao; Hong Kang; Jing-hua Peng; Lin Xu; Zhi-wei Cao; Yi-yang Hu

doi:10.1007/s11655-016-2253-3

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Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B

Updated：2021-08-27

- Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B
- Chinese Journal of Integrative Medicine Vol. 23, Issue 4, Pages: 253-260(2017)
- Affiliations：
  
  1. Institute of Liver Disease, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine,Shanghai,China
  2. School of Life Sciences and Technology, Tongji University,Shanghai,China
  3. institute of Shanghai Municipal Education Commission, Shanghai,E,China
- Author bio：
- Funds：
  
  Supported by National Science and Technology Major Project (No. 2012ZX10005001-004, No. 2012ZX09303009-001), National Natural Science Foundation of China (No. 81403298, No. 81373857), Shanghai Natural Science Foundation of China (No. 14ZR1442000), and Shanghai Educational Development Foundation (No. 14CG41)
- DOI：10.1007/s11655-016-2253-3
  CLC：
- Published：2017，
  
  Published Online：25 May 2016，
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Zhao, Y., Kang, H., Peng, Jh. et al. Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B., Chin. J. Integr. Med. 23, 253–260 (2017). https://doi.org/10.1007/s11655-016-2253-3

Yu Zhao, Hong Kang, Jing-hua Peng, et al. Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B. [J]. Chinese Journal of Integrative Medicine 23(4):253-260(2017)
Zhao, Y., Kang, H., Peng, Jh. et al. Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B., Chin. J. Integr. Med. 23, 253–260 (2017). https://doi.org/10.1007/s11655-016-2253-3 DOI：

Yu Zhao, Hong Kang, Jing-hua Peng, et al. Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B. [J]. Chinese Journal of Integrative Medicine 23(4):253-260(2017) DOI： 10.1007/s11655-016-2253-3.

摘要

To identify key symptoms of two major syndromes in chronic hepatitis B (CHB)

which can be the clinical evidence for Chinese medicine (CM) doctors to make decisions. Standardization scales on diagnosis for CHB in CM were designed including physical symptoms

tongue and pulse appearance. The total of 695 CHB cases with dampness-heat (DH) syndrome or Pi (Spleen) deficiency (SD) syndrome were collected for feature selection and modeling

another 275 CHB patients were collected in different locations for validation. Key symptoms were selected based on modified information gain (IG)

and 5 classifiers were applied to assist with models training and validation. Classification accuracy and area under receiver operating characteristic curves (AUC) were evaluated. (1) Thirteen DH syndrome key symptoms and 13 SD syndrome key symptoms were selected from original 125 symptoms; (2) The key symptoms could achieve similar or better diagnostic accuracy than the original total symptoms; (3) In the validation phase

the key symptoms could identify syndromes effectively

especially in DH syndrome

which average prediction accuracy on 5 classifiers could achieve 0.864 with the average AUC 0.772. The selected key symptoms could be simple DH and SD syndromes diagnostic elements applied in clinical directly. (Registration N0.: ChiCTR-DCC-10000759)

Abstract

To identify key symptoms of two major syndromes in chronic hepatitis B (CHB)

which can be the clinical evidence for Chinese medicine (CM) doctors to make decisions. Standardization scales on diagnosis for CHB in CM were designed including physical symptoms

tongue and pulse appearance. The total of 695 CHB cases with dampness-heat (DH) syndrome or Pi (Spleen) deficiency (SD) syndrome were collected for feature selection and modeling

another 275 CHB patients were collected in different locations for validation. Key symptoms were selected based on modified information gain (IG)

the key symptoms could identify syndromes effectively

especially in DH syndrome

关键词

Chinese Medicinesyndromechronic hepatitis Binformation gain

Keywords

Chinese Medicinesyndromechronic hepatitis Binformation gain

references

Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004;11:97–107.

Liang X, Bi S, Yang W, Wang L, Cui G, Cui F, et al. Epidemiological serosurvey of hepatitis B in China—declining HBV prevalence due to hepatitis B vaccination. Vaccine 2009;27:6550–6557.

Lu FM, Zhang H. Management of hepatitis B in China. Chin Med J 2009;122:3–4.

Beasley RP. Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer 1988;61:1942–1956.

Zeng XX, Bian ZX, Wu TX, Fu SF, Ziea E, Woon WT. Traditional Chinese medicine syndrome distribution in chronic hepatitis B populations: a systematic review. Am J Chin Med 2011;39:1061–1074.

Zhang GG, Singh B, Lee W, Handwerger B, Lao L, Berman B. Improvement of agreement in TCM diagnosis among TCM practitioners for persons with the conventional diagnosis of rheumatoid arthritis: effect of training. J Altern Complement Med 2008;14:381–386.

Wang Y, Yu Z, Jiang Y, Liu Y, Chen L. A framework and its empirical study of automatic diagnosis of traditional Chinese medicine utilizing raw free-text clinical records. J Biomed Inform 2012;45:210–223.

Tang AC, Chung JW, Wong TK. Validation of a novel traditional chinese medicine pulse diagnostic model using an artificial neural network. Evid Based Complement Alternat Med 2012;2012:685094.

Liu GP, Li GZ, Wang YL, Wang YQ. Modelling of inquiry diagnosis for coronary heart disease in traditional Chinese medicine by using multi-label learning. BMC Complement Altern Med 2010;10:37.

Lu P, Chen J, Zhao H, Gao Y, Luo L, Zuo X, et al. In silico syndrome prediction for coronary artery disease in traditional Chinese medicine. Evid Based Complement Alternat Med 2012;2012:142584.

Li F, Zhao C, Xia Z, Wang Y, Zhou X, Li GZ. Computerassisted lip diagnosis on traditional Chinese medicine using multi-class support vector machines. BMC Complement Altern Med 2012;12:127.

Wang LM, Zhao X, Wu XL, Li Y, Yi DH, Cui HT, et al. Diagnosis analysis of 4 TCM patterns in suboptimal health status: a structural equation modelling approach. Evid Based Complement Alternat Med 2012;2012:970985.

Ye YA, Jiang F, Zhao ZM, Li ZH, Zhang L, Liu HQ, et al. Chinese medical pattern distribution of chronic type hepatitis B. J Tradit Chin Med (Chin) 2007;48:256–258.

Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology 2007;45:507–539.

Hepatology and Infectious Diseases Committee of Chinese Medical Association. Guideline on prevention and treatment of chronic hepatitis B in China (2005). Chin J Hepatol (Chin) 2005;13:881–891.

Internal Medicine Hepatopathy Committee of Chinese Traditional Medicine Association. The standards of TCM differential syndromes of viral hepatitis. J Tradit Chin Med (Chin) 1992;5:39–40.

Zheng XY, ed. Guideline for clinical research on new Chinese medicine drugs. Beijing: China Medical Science and Technology Press; 2002.

Kumar AP, Valsala P. Feature selection for high dimensional DNA microarray data using hybrid approaches. Bioinformation 2013;9:824–828.

Cismondi F, Celi LA, Fialho AS, Vieira SM, Reti SR, Sousa JM, et al. Reducing unnecessary lab testing in the ICU with artificial intelligence. Int J Med Inform 2013;82:345–358.

Wang Y, Ma L, Liu P. Feature selection and syndrome prediction for liver cirrhosis in traditional Chinese medicine. Comput Methods Programs Biomed 2009;95:249–257.

Jiang M, Zhang C, Zheng G, Guo H, Li L, Yang J, et al. Traditional chinese medicine zheng in the era of evidencebased medicine: a literature analysis. Evid Based Complement Alternat Med 2012;2012:409568.

Li S. Discussion on the characteristics of TCM syndromes from the concepts of dimensions and ranks: approachs to the standardization of TCM syndromes. J Beijing Univ Tradit Chin Med (Chin) 2003;26:1–4.

Tian JZ, Wang YY, Shi J, Zhu AH, Zhang BL, Huang QF. Concept and attributes of syndrome manifestations. J Beijing Univ Tradit Chin Med (Chin) 2005;28:6–8.

Yu WY, Lu AP, Han XJ, Shi NN, Wang LY, Wang YP, et al. Exploration on syndrome differentiation standardization of Chinese medicine diagnosis and treatment. J Chin Integr Med (Chin) 2011;31:1419–1421.

Gong YB, Ni Q, Wang YY. Modern methodology of TCM syndrome study (I): data mining technology of TCM syndrome. J Beijing Univ Tradit Chin Med (Chin) 2006;29:797–801.

Gong YB, Ni Q,Wang YY. Modern methodology on study of TCM syndrome manifestation (II): quantification and mathematical statistics of TCM syndrome manifestation. J Beijing Univ Tradit Chin Med (Chin) 2007;30:5–8.

Hepatobiliary Disease Group of China Association of Traditional Chinese Medicine, Hepatology Group of World Federation of Chinese Medicine Societies, Hepatology Group of Chinese Association of Integrative Medicine. Guidelines for traditional Chinese medical diagnosis of chronic hepatitis B. J Clin Hepatol (Chin) 2012;28:164–168.

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