Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis

Yu Cao; Long-tao Liu; Min Wu

doi:10.1007/s11655-016-2257-z

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Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis

Updated：2021-08-27

- Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis
- Chinese Journal of Integrative Medicine Vol. 23, Issue 4, Pages: 298-305(2017)
- Affiliations：
  
  1. Department of Cardiovascular Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  2. Gerontology Medical Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81102721 and No. 81202805), a Planned Technologic Item of State Administration of Traditional Chinese Medicine (No. 04-05LP30), Chinese National Scientic Fund for Post-Doctor (No. 20070410622), its Special Aid Item (No. 201003226) and the Key Technologies R & D Program of Shandong Province, China (No. 2010 GSF 10289)
- DOI：10.1007/s11655-016-2257-z
  CLC：
- Published：2017，
  
  Published Online：25 May 2016，
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Cao, Y., Liu, Lt. & Wu, M. Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis., Chin. J. Integr. Med. 23, 298–305 (2017). https://doi.org/10.1007/s11655-016-2257-z

Yu Cao, Long-tao Liu, Min Wu. Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis. [J]. Chinese Journal of Integrative Medicine 23(4):298-305(2017)
Cao, Y., Liu, Lt. & Wu, M. Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis., Chin. J. Integr. Med. 23, 298–305 (2017). https://doi.org/10.1007/s11655-016-2257-z DOI：

Yu Cao, Long-tao Liu, Min Wu. Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis. [J]. Chinese Journal of Integrative Medicine 23(4):298-305(2017) DOI： 10.1007/s11655-016-2257-z.

摘要

To study the efficacy of Chinese medicine (CM) on isolated systolic hypertension. Seven electronic databases were searched for randomized controlled trials (RCTs) published until August 2015. Subgroup analyses and meta-analysis were performed to assess the efficacy and safety of the included studies. A total of 24 studies

including 2

096 patients (1

058 patients in the intervention group and 1

038 in the control group)

were evaluated in the final analysis. Compared with a conventional therapy used alone

CM as additional intervention was more effective on systolic blood pressure [mean difference (MD)=–0.66

95% confidence interval (CI)=(–0.97

–0.36)

P<0.00001] and significantly diminished the pulse pressure [MD=–7.49

CI=(–12.69

–2.29)

P<0.00001]. However it showed no additional benefit on diastolic blood pressure [MD=1.16

CI=(0.02

2.29)

P=0.87]. Adverse events were not explicitly reported in most RCTs. CM might be a promising approach for the elderly with isolated systolic hypertension

while the evidence for CM employed alone was insufficient. Considering the inherent limitations of the included studies

larger high-quality RCTs with extensive follow-up should be performed to validate our findings in the future.

Abstract

including 2

096 patients (1

058 patients in the intervention group and 1

038 in the control group)

were evaluated in the final analysis. Compared with a conventional therapy used alone

CM as additional intervention was more effective on systolic blood pressure [mean difference (MD)=–0.66

95% confidence interval (CI)=(–0.97

–0.36)

P<0.00001] and significantly diminished the pulse pressure [MD=–7.49

CI=(–12.69

–2.29)

P<0.00001]. However it showed no additional benefit on diastolic blood pressure [MD=1.16

CI=(0.02

2.29)

P=0.87]. Adverse events were not explicitly reported in most RCTs. CM might be a promising approach for the elderly with isolated systolic hypertension

while the evidence for CM employed alone was insufficient. Considering the inherent limitations of the included studies

larger high-quality RCTs with extensive follow-up should be performed to validate our findings in the future.

关键词

Chinese Herbal Medicineisolated systolic hypertensionmeta-analysissystematic reviewrandomized controlled trial

Keywords

Chinese Herbal Medicineisolated systolic hypertensionmeta-analysissystematic reviewrandomized controlled trial

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Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases

Division of Infectious Diseases, Chinese PLA Hospital

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Guang’anmen Hospital, China Academy of Chinese Medical Sciences

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