Neuroprotective Effects of Electroacupuncture Preventive Treatment in Senescence-Accelerated Mouse Prone 8 Mice

Xiao-li He; Shi-hui Zhao; Wei You; Yu-ying Cai; Yan-yun Wang; Yong-ming Ye; Bao-hui Jia

doi:10.1007/s11655-016-2265-z

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Neuroprotective Effects of Electroacupuncture Preventive Treatment in Senescence-Accelerated Mouse Prone 8 Mice

Updated：2021-08-27

- Neuroprotective Effects of Electroacupuncture Preventive Treatment in Senescence-Accelerated Mouse Prone 8 Mice
- Chinese Journal of Integrative Medicine Vol. 24, Issue 2, Pages: 133-139(2018)
- Affiliations：
  
  1. Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
  2. Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  3. Beijing Hospital of Traditional Chinese Medicine, Capital Medical University,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natureal Science Foundation of China (No. 30701121)
- DOI：10.1007/s11655-016-2265-z
  CLC：
- Published：2018，
  
  Published Online：26 September 2016，
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He, Xl., Zhao, Sh., You, W. et al. Neuroprotective Effects of Electroacupuncture Preventive Treatment in Senescence-Accelerated Mouse Prone 8 Mice., Chin. J. Integr. Med. 24, 133–139 (2018). https://doi.org/10.1007/s11655-016-2265-z

Xiao-li He, Shi-hui Zhao, Wei You, et al. Neuroprotective Effects of Electroacupuncture Preventive Treatment in Senescence-Accelerated Mouse Prone 8 Mice. [J]. Chinese Journal of Integrative Medicine 24(2):133-139(2018)
He, Xl., Zhao, Sh., You, W. et al. Neuroprotective Effects of Electroacupuncture Preventive Treatment in Senescence-Accelerated Mouse Prone 8 Mice., Chin. J. Integr. Med. 24, 133–139 (2018). https://doi.org/10.1007/s11655-016-2265-z DOI：

Xiao-li He, Shi-hui Zhao, Wei You, et al. Neuroprotective Effects of Electroacupuncture Preventive Treatment in Senescence-Accelerated Mouse Prone 8 Mice. [J]. Chinese Journal of Integrative Medicine 24(2):133-139(2018) DOI： 10.1007/s11655-016-2265-z.

摘要

To investigate the preventive treatment effects of electroacupuncture (EA) on cognitive changes and brain damage in senescence-accelerated mouse prone 8 (SAMP8) mice. The 5-month-old male SAMP8 and age-matched homologous normal aging mice (SAMR1) were adopted in this study. EA stimulation at Baihui (GV 20) and Yintang (EX-HN 3) was performed every other day for 12 weeks

4 weeks as a course. Morris water maze test and Nissl-stained with cresyl violet were used for cognitive impairments evaluation and brain morphometric analysis. Amyloid-β (A β) expression in hippocampus and parietal cortex was detected by immunohistochemistry

and apoptosis was observed by TUNEL staining. After 3 courses of EA preventive treatment

the escape latencies of 8-month-old SAMP8 mice in EA group were significantly shortened than those of un-pretreated SAMP8 mice. Compared with SAMR1 mice

extensive neuronal changes were visualized in the CA1 area of hippocampus in SAMP8 mice

while these pathological changes and attenuate cell loss in hippocampal CA1 area of SAMP8 mice markedly reduced after EA preventive treatment. Furthermore

A β expression in hippocampus and parietal cortex of SAMP8 mice decreased significantly after EA treatment

and neuronal apoptosis decreased as well. EA preventive treatment at GV 20 and EX-HN 3 might improve cognitive deficits and neuropathological changes in SAMP8 mice

which might be

at least in part

due to the effects of reducing brain neuronal damage

decreasing neuronal apoptosis and inhibiting A β-containing aggregates.

Abstract

and apoptosis was observed by TUNEL staining. After 3 courses of EA preventive treatment

the escape latencies of 8-month-old SAMP8 mice in EA group were significantly shortened than those of un-pretreated SAMP8 mice. Compared with SAMR1 mice

extensive neuronal changes were visualized in the CA1 area of hippocampus in SAMP8 mice

while these pathological changes and attenuate cell loss in hippocampal CA1 area of SAMP8 mice markedly reduced after EA preventive treatment. Furthermore

A β expression in hippocampus and parietal cortex of SAMP8 mice decreased significantly after EA treatment

and neuronal apoptosis decreased as well. EA preventive treatment at GV 20 and EX-HN 3 might improve cognitive deficits and neuropathological changes in SAMP8 mice

which might be

at least in part

due to the effects of reducing brain neuronal damage

decreasing neuronal apoptosis and inhibiting A β-containing aggregates.

关键词

electroacupuncturesenescence-accelerated mouse prone 8 micepreventionlearning and memorycognitive impairmentbrain damage

Keywords

electroacupuncturesenescence-accelerated mouse prone 8 micepreventionlearning and memorycognitive impairmentbrain damage

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Department of Integrated Chinese and Western Medicine, West China Hospital of Sichuan University

Department of Integrative Cardiology, China-Japan Friendship Hospital

Department of Cardiology, China-Japan Friendship Hospital

Department of Biochemistry, Institute of Basic Medicine, Shanghai University of Traditional Chinese Medicine

Institute of Cardiovascular Diseases, Pingjin Hospital, Medical College of Armed Police Forces

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