Danshen injection as adjuvant treatment for unstable angina pectoris: A systematic review and meta-analysis

Jia-rui Wu; Shi Liu; Xiao-meng Zhang; Bing Zhang

doi:10.1007/s11655-016-2272-0

Your Location：

Home >

Browse articles >

Danshen injection as adjuvant treatment for unstable angina pectoris: A systematic review and meta-analysis

Updated：2021-08-27

- Danshen injection as adjuvant treatment for unstable angina pectoris: A systematic review and meta-analysis
- Chinese Journal of Integrative Medicine Vol. 23, Issue 4, Pages: 306-311(2017)
- Affiliations：
  
  Department of Clinical Pharmacology of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81473547) and Scientic Research Innovation Team Project of Beijing University of Chinese Medicine, China (No. 2011-CXTD-14)
- DOI：10.1007/s11655-016-2272-0
  CLC：
- Published：2017，
  
  Published Online：5 December 2016，
Scan for full text
Wu, Jr., Liu, S., Zhang, Xm. et al. Danshen injection as adjuvant treatment for unstable angina pectoris: A systematic review and meta-analysis., Chin. J. Integr. Med. 23, 306–311 (2017). https://doi.org/10.1007/s11655-016-2272-0

Jia-rui Wu, Shi Liu, Xiao-meng Zhang, et al. Danshen injection as adjuvant treatment for unstable angina pectoris: A systematic review and meta-analysis. [J]. Chinese Journal of Integrative Medicine 23(4):306-311(2017)
Wu, Jr., Liu, S., Zhang, Xm. et al. Danshen injection as adjuvant treatment for unstable angina pectoris: A systematic review and meta-analysis., Chin. J. Integr. Med. 23, 306–311 (2017). https://doi.org/10.1007/s11655-016-2272-0 DOI：

Jia-rui Wu, Shi Liu, Xiao-meng Zhang, et al. Danshen injection as adjuvant treatment for unstable angina pectoris: A systematic review and meta-analysis. [J]. Chinese Journal of Integrative Medicine 23(4):306-311(2017) DOI： 10.1007/s11655-016-2272-0.

摘要

To systematically evaluate the clinical effectiveness and safety of Danshen Injection (丹参注射液

DS) as one adjuvant treatment for conventional therapy with Western medicine (WM) for unstable angina pectoris (UAP). Using literature databases

a thorough and systematic retrieval of randomized controlled trials (RCTs) comparing DS plus WM with WM was conducted from inception to April 2015. The extracted data from included studies was analyzed by Review Manager 5.2 software. The Cochrane risk of bias tool was used to assess the quality of included studies

and Begg’s and Egger’s tests conducted by Stata 12.0 were used to evaluate the potential presence of publication bias. A total of 17 RCTs

which involving 1

433 participants

were identified and reviewed. The meta-analysis indicated that the combined use of DS and WM was significantly superior to WM alone for UAP in terms of the total effectiveness rate of angina pectoris [risk ratio (RR) =1.23

95% confidence interval (CI): 1.17

1.29

P<0.01] and the total effectiveness rate of electrocardiogram (ECG) [RR=1.18

95%CI: 1.06

1.30

P=0.001]. Additionally

DS could also further reduce the content of fibrinogen

adjust blood lipid level

correct T wave inversion

and so on. Fifteen adverse drug reactions were reported in two studies

Four of which appeared in the experimental group. Based on the systematic review

the combined use of DS and WM was more effective than WM alone

it can be further widely used in clinic

however

there was no exact conclusion for its safety.

Abstract

To systematically evaluate the clinical effectiveness and safety of Danshen Injection (丹参注射液

DS) as one adjuvant treatment for conventional therapy with Western medicine (WM) for unstable angina pectoris (UAP). Using literature databases

and Begg’s and Egger’s tests conducted by Stata 12.0 were used to evaluate the potential presence of publication bias. A total of 17 RCTs

which involving 1

433 participants

95% confidence interval (CI): 1.17

1.29

P<0.01] and the total effectiveness rate of electrocardiogram (ECG) [RR=1.18

95%CI: 1.06

1.30

P=0.001]. Additionally

DS could also further reduce the content of fibrinogen

adjust blood lipid level

correct T wave inversion

and so on. Fifteen adverse drug reactions were reported in two studies

Four of which appeared in the experimental group. Based on the systematic review

the combined use of DS and WM was more effective than WM alone

it can be further widely used in clinic

however

there was no exact conclusion for its safety.

关键词

Danshen Injectionunstable angina pectorissystemic reviewmeta-analysis

Keywords

Danshen Injectionunstable angina pectorissystemic reviewmeta-analysis

references

Han YJ, Sheng XG. Treatment situation of unstable angina pectoris. J Tradit Chin Med (Chin) 2007;48:945.

Parikh R, Kadowitz PJ. Angina pectoris: current therapy and future treatment options. Expert Rev Cardiovascular Therapy 2014;12:175–186.

Liu DH. 395 cases of coronary heart disease angina pectoris syndrome characteristics of traditional Chinese medicine research. J Tradit Chin Med (Chin) 2002;36:617.

Zhang ZH, Zhao HX. Clinical research in the treatment with Danshen Injection for unstable angina pectoris. J Emerg Tradit Chin Med (Chin) 2001;10(5):267.

International Heart Association and WHO Standardization Joint Workshops. Nomenclature and diagnostic criteria of ischemic heart disease. Chin J Cardio (Chin) 1981;9(1):75.

Editorial Committee of Chinese Journal of Cardiology. Diagnosis of unstable angina pectoris. Chin J Cardio (Chin) 2000;28:409.

The Editorial Board of Chinese Journal of Cardiology in Cardiovascular Medicine Groups. Guiding principles of clinical research of cardiovascular system drug. Chin J Clin Pharm (Chin) 1988;4:245–255.

Higgins JP, Altman DG, Gφtzsche PC, Jlini P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in random trials. BMJ 2011;343:d5928.

Review Manager (RevMan, Computer program). Version5.2. Copenhagen: The Nordic Cochrane Centre: The Cochrane Collaboration; 2012.

Zheng MH, ed. Applications and example analyzation of the meta-analysis software. Beijing: People’s Medical Publishing House; 2013:4.

Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994;50:1088–1101.

Egger M, Davey SG, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629–634.

Cao C. Clinical study in 104 cases of Danshen Injection in treatment of unstable angina pectoris. Chin Med Guid (Chin) 2010;12:249–251.

Cheng RQ. Clinical study in 45 cases of Danshen Injection in treatment of unstable angina pectoris. Chin Med Guid (Chin) 2007;4(23):77–78.

Ding QY, Zou WW. The clinical effectiveness of Danshen Injection combined with simvastatin in treating unstable angina pectoris. Med Inform (Chin) 2010;6:1537.

Hu YZ, Yang B, Liu DB, Feng DH. The effects of Danshen Injection on intercellular adhesion molecules-1 in treatment of acute cerebral infarction. Chin Med Guid (Chin) 2004;23:807–809.

Li X. The clinical effectiveness of Danshen Injection combined with Western medicine in treating unstable angina pectoris. J Hunan Univ Chin Med (Chin) 2006;26(2):28–29.

Liang HS, Li KF, Deng WX. Clinical research in the treatment with Danshen injection for unstable angina pectoris. Chin J Pract Inter Med (Chin) 2006;26:198–199.

Pan LP. Clinical research in the treatment with Danshen Injection for unstable angina pectoris. China Foreign Med Treat (Chin) 2011;16:74.

Qian YL, Sun YP, Chen B. Clinical study in 32 cases of Danshen Injection in treating patients with unstable angina pectoris. Chin J Integr Tradit West Med (Chin) 2000;20:700–701.

Shao M. The clinical effectiveness of Danshen Injection in treating unstable angina pectoris. J Anhui Univ Tradit Chin Med (Chin) 2003;22:13–16.

Song SL, Zheng JY, Xin CY. The clinical effectiveness of Danshen Injection in treating unstable angina pectoris. China Health Care Nutrition (Chin) 2013;12:420–421.

Wang XL, Zhang YL. The clinical effectiveness of Danshen Injection combined with isosorbide mononitrate in treating unstable angina pectoris. Chin J Primary Med Pharm (Chin) 2007;14:1388.

Wang XB, Wu HY. The clinical effectiveness of Danshen Injection combined with Western medicine in treating unstable angina pectoris. J Pract Tradit Chin Inter Med (Chin) 2013;27:104–105.

Wei SX. The clinical effectiveness of Danshen Injection combined with simvastatin in treating unstable angina pectoris. Youjiang Med (Chin) 2012;40:501–503.

Wu XH, Liang Q, Yang H, Wang YS, Zheng YH. Clinical study in 38 cases of Danshen Injection combined with simvastatin in treatment of acute cerebral Infarction. Jiangxi J Tradit Chin Med (Chin) 2010;41(7):23–24.

Yan LS, Liu XQ, Zhang Y. The clinical effectiveness of Danshen Injection in treatment of unstable angina pectoris. Chin Community Doctors (Chin) 2015;31(5):95–96.

Zhao QE. Clinical study in 66 cases of Danshen Injection in treatment of unstable angina pectoris. Chin Community Doctors (Chin) 2013;15(3):134.

Zhu Y, He YH. The clinical effect of Danshen Injection in treating patients with unstable angina pectoris. J Emerg Trad Chin Med (Chin) 2002;11:253–254.

Zhang SR, Xu LX, Gao QQ. Meta-analysis of the relationship between C-reactive protein level in Chinese population and prognosis of unstable angina pectoris. J Zhejiang Clin Med (Chin) 2006;8:344–345.

Wang ZY, Wang YQ, Li M. Analysis of 302 cases of adverse reactions occurred in Danshen Injection. Chin Pharm (Chin) 2010;21:3035–3037.

Wu JR, ed. Adverse reactions and safety of traditional Chinese medicine injections. Beijing: Chinese Press of Traditional Chinese Medicine; 2012:171.

FULL TEXT LINK

More>

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Effectiveness and Safety of Chinese Medicine at Shenque (CV 8) for Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Placebo Response among Different Types of Sham Acupuncture for Low Back Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Related Author

No data

Related Institution

Guang’anmen Hospital, China Academy of Chinese Medical Sciences

Institution of Hematology Research, The First Affiliated Hospital, Zhejiang Chinese Medical University

Department of Hematology, Lishui Central Hospital

China Academy of Chinese Medical Sciences

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰