<italic style="font-style: italic">In Vitro</italic> and <italic style="font-style: italic">In Vivo</italic> Antibacterial Activity of Patchouli Alcohol from <italic style="font-style: italic">Pogostemon cablin</italic>

Feng WAN; Fu PENG; Liang XIONG; Jian-ping CHEN; Cheng PENG; Min DAI

doi:10.1007/s11655-016-2452-y

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In Vitro and In Vivo Antibacterial Activity of Patchouli Alcohol from Pogostemon cablin

Original Article | Updated：2021-08-16

- In Vitro and In Vivo Antibacterial Activity of Patchouli Alcohol from Pogostemon cablin
- Chinese Journal of Integrative Medicine Vol. 27, Issue 2, Pages: 125-130(2021)
- Affiliations：
  
  1.School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu (610075), China
  2.State Key Laboratory Breeding Base of Systematic Research,Development and Utilization of Chinese Medicine Resources,Sichuan Province and Ministry of Science and Technology,Chengdu (610075), China
  3.School of Chinese Medicine, the University of Hong Kong, Hong Kong SAR, China
  4.School of Medical Laboratory Science, Chengdu Medical College, Chengdu (610500), China
- Author bio：
  
  Correspondence to: Prof. PENG Cheng, E-mail:pengchengchengdu@126.com
- Funds：
- DOI：10.1007/s11655-016-2452-y
  CLC：
- Published：01 February 2021，
  
  Published Online：13 April 2016，
  
  Accepted：07 February 2016
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Feng WAN, Fu PENG, Liang XIONG, et al. In Vitro and In Vivo Antibacterial Activity of Patchouli Alcohol from Pogostemon cablin. [J]. Chinese Journal of Integrative Medicine 27(2):125-130(2021)
DOI：

Feng WAN, Fu PENG, Liang XIONG, et al. In Vitro and In Vivo Antibacterial Activity of Patchouli Alcohol from Pogostemon cablin. [J]. Chinese Journal of Integrative Medicine 27(2):125-130(2021) DOI： 10.1007/s11655-016-2452-y.

摘要

Abstract

Objective:

To investigate the antibacterial activity of patchouli alcohol (PA) against 127 bacteria strains

including the common bacteria and drug-resistant bacteria strains both in the

in vitro

and

in vivo

tests.

Methods:

For the

in vitro

trial

the antibacterial property of PA against 107 Gram-positive and 20 Gram-negative bacteria strains was screened by agar double dilution method. For the

in vivo

trial

specific pathogen free Kunming strain of both male and female white mice

were used to test the protective ability of PA after being injected with the median lethal dose of the tested strains.

Results:

PA possessed antibacterial activity against all the tested 127 strains. In the

in vitro

test

PA could inhibit both Gram-negative bacteria (25–768 μg/mL) and Gram-positive bacteria (1.5–200 μg/mL). Particularly

PA was active against some drug-resistant bacteria like methicillin-resistant

Staphylococcus aureus

(MRSA). PA also exhibited

in vivo

anti-MRSA activity in mice via intraperitoneal injection. PA could protect mice entirely infected with MRSA at 100 and 200 mg/kg

while 80% mice injected with MRSA could be protected at a low dose of 50 mg/kg.

Conclusion:

PA might be a potential antibacterial drug from natural sources and might be worthy to explore its mechanism and application in further study.

关键词

Keywords

patchouli alcoholantibacterial activitydrug-resistant bacteriain vivoin vitro

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In Vitro and In Vivo Antibacterial Activity of Patchouli Alcohol from Pogostemon cablin

DOI：10.1007/s11655-016-2452-y

摘要

Abstract

关键词

Keywords

references