Chemical Composition, Anticancer, Anti-neuroinflammatory, and Antioxidant Activities of the Essential Oil of Patrinia scabiosaefolia

Jing Lin; Qiao-yan Cai; Wen Xu; Jiu-mao Lin; Jun Peng

doi:10.1007/s11655-016-2459-4

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Chemical Composition, Anticancer, Anti-neuroinflammatory, and Antioxidant Activities of the Essential Oil of Patrinia scabiosaefolia

Updated：2021-08-27

- Chemical Composition, Anticancer, Anti-neuroinflammatory, and Antioxidant Activities of the Essential Oil of Patrinia scabiosaefolia
- Chinese Journal of Integrative Medicine Vol. 24, Issue 3, Pages: 207-212(2018)
- Affiliations：
  
  1. Academy of Integrative Medicine Biomedical Research Center, Fujian University of Traditional Chinese Medicine,Fuzhou,China
  2. Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine,Fuzhou,China
  3. Department of Pharmacology, Fujian University of Traditional Chinese Medicine,Fuzhou,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81403390), the Provincial Natural Science Foundation of Fujian (No. 2014J01352 and No. 2014J01360), Provincial Health Department Foundation of Fujian (No. 2013-2-55), Fujian University of Traditional Chinese Medicine Key Discipline Construction Foundation (Nos. X2012012, X2013014, X2013015, X2014132 and X2015020)
- DOI：10.1007/s11655-016-2459-4
  CLC：
- Published：2018，
  
  Published Online：1 September 2016，
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Lin, J., Cai, Qy., Xu, W. et al. Chemical Composition, Anticancer, Anti-neuroinflammatory, and Antioxidant Activities of the Essential Oil of Patrinia scabiosaefolia., Chin. J. Integr. Med. 24, 207–212 (2018). https://doi.org/10.1007/s11655-016-2459-4

Jing Lin, Qiao-yan Cai, Wen Xu, et al. Chemical Composition, Anticancer, Anti-neuroinflammatory, and Antioxidant Activities of the Essential Oil of Patrinia scabiosaefolia. [J]. Chinese Journal of Integrative Medicine 24(3):207-212(2018)
Lin, J., Cai, Qy., Xu, W. et al. Chemical Composition, Anticancer, Anti-neuroinflammatory, and Antioxidant Activities of the Essential Oil of Patrinia scabiosaefolia., Chin. J. Integr. Med. 24, 207–212 (2018). https://doi.org/10.1007/s11655-016-2459-4 DOI：

Jing Lin, Qiao-yan Cai, Wen Xu, et al. Chemical Composition, Anticancer, Anti-neuroinflammatory, and Antioxidant Activities of the Essential Oil of Patrinia scabiosaefolia. [J]. Chinese Journal of Integrative Medicine 24(3):207-212(2018) DOI： 10.1007/s11655-016-2459-4.

摘要

To study the chemical composition

anticancer

anti-neuroinflflammatory

and antioxidant activities of the essential oil of Patrinia scabiosaefolia (EO-PS). Patrinia scabiosaefolia was analyzed by gas chromatography-mass spectrometry. Eight human carcinoma cell lines

including SGC-7901

AGS

HepG2

HT-29

HCT-8

5-FU/HCT-8

HeLa

and MDA-MB-231

were assessed by methylthiazolyldiphenyltetrazolium bromide (MTT) assay. Anti-neuroinflflammatory activity was assessed by production of interleukin (IL)-1β and IL-6 induced by lipopolysaccharide in BV-2 cells (microglia from mice). The antioxidant activity was evaluated with a 2

2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay. Forty-four components

representing 83.919% of the total oil

were identifified in the EO-PS. The major constituents were caryophyllene oxide (12.802%)

caryophyllene (6.909%)

α-caryophyllene (2.927%)

β-damascenone (3.435%)

calarene (5.621%)

and phenol (3.044%). The MTT assay showed that the EO-PS exhibited significant dose-dependent growth inhibition in the 50–200 μg/mL dilution range. The EO-PS exhibited a dose-dependent scavenging activity against the DPPH radical

with an half of maximal inhibitory concentration 1.455 mg/mL. The EO-PS possesses a wide range of antitumor

anti-neuroinflflammatory and antioxidant activities

suggesting that it may be a good candidate for further investigations of new bioactive substances.

Abstract

To study the chemical composition

anticancer

anti-neuroinflflammatory

and antioxidant activities of the essential oil of Patrinia scabiosaefolia (EO-PS). Patrinia scabiosaefolia was analyzed by gas chromatography-mass spectrometry. Eight human carcinoma cell lines

including SGC-7901

AGS

HepG2

HT-29

HCT-8

5-FU/HCT-8

HeLa

and MDA-MB-231

2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay. Forty-four components

representing 83.919% of the total oil

were identifified in the EO-PS. The major constituents were caryophyllene oxide (12.802%)

caryophyllene (6.909%)

α-caryophyllene (2.927%)

β-damascenone (3.435%)

calarene (5.621%)

with an half of maximal inhibitory concentration 1.455 mg/mL. The EO-PS possesses a wide range of antitumor

anti-neuroinflflammatory and antioxidant activities

suggesting that it may be a good candidate for further investigations of new bioactive substances.

关键词

Patrinia scabiosaefoliaessential oilanti-neuroinflflammatoryanticancerantioxidantcaryophyllene oxide

Keywords

Patrinia scabiosaefoliaessential oilanti-neuroinflflammatoryanticancerantioxidantcaryophyllene oxide

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Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine

Department of Neurology, Shanghai Tong-Ren Hospital, Shanghai Jiao Tong University School of Medicine

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