Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation

Guang Yang; Rui-ying Hu; Ai-jing Deng; Yu Huang; Jian Li

doi:10.1007/s11655-016-2462-9

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Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation

Updated：2021-08-27

- Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation
- Chinese Journal of Integrative Medicine Vol. 22, Issue 3, Pages: 219-224(2016)
- Affiliations：
  
  1. Intensive Care Unit, Guangdong Provincal Hospital of Traditional Chinese Medicine,Guangzhou,China
  2. Intensive Care Unit, Wuhan Hospital of Traditional Chinese Medicine,Wuhan,China
- Author bio：
- Funds：
  
  Supported by Project of Chinese Medicine Bureau of Guangdong Province (No. 20121199);Guangdong Provincial Department of Science and Technology Project (No. 2014A020212279)
- DOI：10.1007/s11655-016-2462-9
  CLC：
- Published：2016，
  
  Published Online：29 January 2016，
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Yang, G., Hu, Ry., Deng, Aj. et al. Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation., Chin. J. Integr. Med. 22, 219–224 (2016). https://doi.org/10.1007/s11655-016-2462-9

Guang Yang, Rui-ying Hu, Ai-jing Deng, et al. Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation. [J]. Chinese Journal of Integrative Medicine 22(3):219-224(2016)
Yang, G., Hu, Ry., Deng, Aj. et al. Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation., Chin. J. Integr. Med. 22, 219–224 (2016). https://doi.org/10.1007/s11655-016-2462-9 DOI：

Guang Yang, Rui-ying Hu, Ai-jing Deng, et al. Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation. [J]. Chinese Journal of Integrative Medicine 22(3):219-224(2016) DOI： 10.1007/s11655-016-2462-9.

摘要

To evaluate the effect of electro-acupuncture on Zusanli (ST 36)

Guanyuan (RN 4) in patients with sepsis

and explore its mechanism in term of immune regulation. In this prospective randomized controlled trial

60 patients with sepsis were randomly assigned to the control group and the intervention group equally by block randomization. Patients in the control group received routine treatment and those in the intervention group received electro-acupuncture at bilateral Zusanli and Guanyuan in addition to routine treatment

respectively. The mortality at 28 days

Acute Physiology and Chronic Health Evaluation (APACHE)-II score were compared to evaluate the effect

and the levels of T cell subsets (CD3+

CD4+

CD8+

CD4+/CD8+) and monocytes of human leukocyte antigen (HLA)-DR using flow cytometry were compared to explore the mechanism of this combined treatment. Fifty-eight patients completed the trial with 29 in each group. There was no significant difference of mortality in the 28th day between the two groups

with 5 death of 29 patients in the intervention group (17.2%) and 9 of 29 in the control group (31.0%). After treatment

APACHE-II score of both groups was significantly decreased

however

score of the intervention group was lower than the control group (13.28±7.07 vs. 17.10±5.83; P<0.01). The levels of CD3+

CD4+

CD8+ and CD4+/CD8+ ratio of the intervention group improved after treatment and were higher than the control group (59.71%±11.94% vs. 52.54%±11.86%; 36.46%±7.60% vs. 31.58%±10.23%; 18.40%±8.82% vs. 23.07%±7.30%; 2.38±1.14 vs. 1.54±0.80

respectively; all P<0.05). The expression of HLA-DR significantly increased after treatment in the intervention group than that in the control group (7.28%±9.26% vs. 1.27%±7.00%; P<0.01). Electro-acupuncture at Zusanli and Guanyuan could improve clinical curative effect in patients with sepsis

which might be achieved by regulation of the immune system.

Abstract

To evaluate the effect of electro-acupuncture on Zusanli (ST 36)

Guanyuan (RN 4) in patients with sepsis

and explore its mechanism in term of immune regulation. In this prospective randomized controlled trial

respectively. The mortality at 28 days

Acute Physiology and Chronic Health Evaluation (APACHE)-II score were compared to evaluate the effect

and the levels of T cell subsets (CD3+

CD4+

CD8+

with 5 death of 29 patients in the intervention group (17.2%) and 9 of 29 in the control group (31.0%). After treatment

APACHE-II score of both groups was significantly decreased

however

score of the intervention group was lower than the control group (13.28±7.07 vs. 17.10±5.83; P<0.01). The levels of CD3+

CD4+

which might be achieved by regulation of the immune system.

关键词

sepsiselectro-acupunctureST36RN4immunohematologyclinical trial

Keywords

sepsiselectro-acupunctureST36RN4immunohematologyclinical trial

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Department of Law, School of Humanities, Inner Mongolia University of Technology

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