Inhibition of pathological angiogenesis of Chinese medicine against liver fibrosis

Ping Liu

doi:10.1007/s11655-016-2468-3

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Inhibition of pathological angiogenesis of Chinese medicine against liver fibrosis

Updated：2021-08-27

- Inhibition of pathological angiogenesis of Chinese medicine against liver fibrosis
- Chinese Journal of Integrative Medicine Vol. 22, Issue 8, Pages: 569-572(2016)
- Affiliations：
  
  Shanghai University of Traditional Chinese Medicine,Shanghai,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-016-2468-3
  CLC：
- Published：2016，
  
  Published Online：23 April 2016，
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Liu, P. Inhibition of pathological angiogenesis of Chinese medicine against liver fibrosis., Chin. J. Integr. Med. 22, 569–572 (2016). https://doi.org/10.1007/s11655-016-2468-3

Ping Liu. Inhibition of pathological angiogenesis of Chinese medicine against liver fibrosis. [J]. Chinese Journal of Integrative Medicine 22(8):569-572(2016)
Liu, P. Inhibition of pathological angiogenesis of Chinese medicine against liver fibrosis., Chin. J. Integr. Med. 22, 569–572 (2016). https://doi.org/10.1007/s11655-016-2468-3 DOI：

Ping Liu. Inhibition of pathological angiogenesis of Chinese medicine against liver fibrosis. [J]. Chinese Journal of Integrative Medicine 22(8):569-572(2016) DOI： 10.1007/s11655-016-2468-3.

摘要

Pathological angiogenesis of liver which includes liver sinusoidal capillarization due to lose of fenestraes of liver sinusoidal endothelial cells (LSECs) and formation of new vascular

is a crucial mechanism responsible for origination and development of liver fifibrosis and closely involves in the development of cirrhosis and hepatic cancer. Anti-neovascularization medicine such as sorafenib can decrease portosystemic shunts

improve splanchnic hyperdynamic circulation

lower portal hypertension

while it can not be applied in clinic due to its serious toxic and side reactions. Chinese herbal formula can effectively inhibit pathological angiogenesis of liver

improve microcirculation of liver

and decrease the probability of gastrointestinal hemorrhage in cirrhotic patients. Different Chinese herbal formula are of different characteristics on inhibiting pathological angiogenesis in liver fifibrosis

which partly explains synergistic effect of different compatibility of Chinese materia medica and opens up good vista for Chinese medicine against liver fifibrosis through inhibiting angiogenesis.

Abstract

Pathological angiogenesis of liver which includes liver sinusoidal capillarization due to lose of fenestraes of liver sinusoidal endothelial cells (LSECs) and formation of new vascular

improve splanchnic hyperdynamic circulation

lower portal hypertension

while it can not be applied in clinic due to its serious toxic and side reactions. Chinese herbal formula can effectively inhibit pathological angiogenesis of liver

improve microcirculation of liver

which partly explains synergistic effect of different compatibility of Chinese materia medica and opens up good vista for Chinese medicine against liver fifibrosis through inhibiting angiogenesis.

关键词

pathological angiogenesisliver fifibrosisChinese Medicine

Keywords

pathological angiogenesisliver fifibrosisChinese Medicine

references

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Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine

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Department of Pharmacology, Hanlin College, Nanjing University of Chinese Medicine

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