Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats

Ji-Hwan Eom; Se-Yun Cheon; Kyung-Sook Chung; Myung-Dong Kim; Hyo-Jin An

doi:10.1007/s11655-016-2528-8

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Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats

Updated：2021-08-27

- Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats
- Chinese Journal of Integrative Medicine Vol. 23, Issue 8, Pages: 611-616(2017)
- Affiliations：
  
  1. Department of Physiology, College of Korean Medicine, Sangji University, Wonju-si Gangwon-do, Republic of Korea
  2. Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si Gangwon-do, Republic of Korea
- Author bio：
- Funds：
  
  Supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning(NRF- 2016R1C1B2011827)
- DOI：10.1007/s11655-016-2528-8
  CLC：
- Published：2017，
  
  Published Online：12 November 2016，
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Eom, JH., Cheon, SY., Chung, KS. et al. Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats., Chin. J. Integr. Med. 23, 611–616 (2017). https://doi.org/10.1007/s11655-016-2528-8

Ji-Hwan Eom, Se-Yun Cheon, Kyung-Sook Chung, et al. Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats. [J]. Chinese Journal of Integrative Medicine 23(8):611-616(2017)
Eom, JH., Cheon, SY., Chung, KS. et al. Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats., Chin. J. Integr. Med. 23, 611–616 (2017). https://doi.org/10.1007/s11655-016-2528-8 DOI：

Ji-Hwan Eom, Se-Yun Cheon, Kyung-Sook Chung, et al. Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats. [J]. Chinese Journal of Integrative Medicine 23(8):611-616(2017) DOI： 10.1007/s11655-016-2528-8.

摘要

To evaluate the efficacy of Bawu Decoction (八物汤

BWD

Palmul-tang in Korean) against benign prostatic hyperplasia (BPH). Twenty-four male Wistar rats were divided into 4 groups

with 6 rats in each group. The 4 study groups included sham-operated group (CON)

BPH model group

fifinasteride-treated group

and BWD-treated group. All the groups except CON group received a subcutaneous injection of 10 mg/kg of testosterone

while CON group received saline. Finasteride at a dose of 5 mg/kg was administered to the finasteride-treated group for a period of 4 weeks. BWD group received BWD at a dose of 200 mg/kg for 4 weeks. The prostatic weight

prostate weight to body weight ratio

relative prostate weight ratio

serum testosterone and dihydrotestosterone (DHT) level

and histological analysis of prostatic tissue were analyzed. Compared to BPH model group

BWD administration was associated with reductions in prostatic weight

prostate and relative prostate weight ratio weight to body weight ratio (P<0.05). The concentration of serum testosterone and DHT were higher in BPH group compared with CON group (P<0.05). Administration of finasteride and BWD suppressed the elevation of serum testosterone and DHT levels signifificantly (both P<0.05). In addition

BWD suppressed the growth of prostatic tissue (P<0.05). BWD has suppressant effects on development of BPH through inhibition of serum testosterone and DHT.

Abstract

To evaluate the efficacy of Bawu Decoction (八物汤

BWD

Palmul-tang in Korean) against benign prostatic hyperplasia (BPH). Twenty-four male Wistar rats were divided into 4 groups

with 6 rats in each group. The 4 study groups included sham-operated group (CON)

BPH model group

fifinasteride-treated group

and BWD-treated group. All the groups except CON group received a subcutaneous injection of 10 mg/kg of testosterone

prostate weight to body weight ratio

relative prostate weight ratio

serum testosterone and dihydrotestosterone (DHT) level

and histological analysis of prostatic tissue were analyzed. Compared to BPH model group

BWD administration was associated with reductions in prostatic weight

BWD suppressed the growth of prostatic tissue (P<0.05). BWD has suppressant effects on development of BPH through inhibition of serum testosterone and DHT.

关键词

benign prostatic hyperplasiaBawu DecotionPalmul-tangfinasterideTestosteronedihydrotesteronerat

Keywords

benign prostatic hyperplasiaBawu DecotionPalmul-tangfinasterideTestosteronedihydrotesteronerat

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