Evaluation of the potential inhibitory activity of a combination of L. acidophilus, L. rhamnosus and L. sporogenes on Helicobacter pylori: A randomized double-blind placebo-controlled clinical trial

Chien-Ying Lee; Hung-Che Shih; Min-Chien Yu; Ming-Yung Lee; Ya-Lan Chang; Ya-Yun Lai; Yi-Ching Lee; Yu-Hsiang Kuan; Chun-Che Lin

doi:10.1007/s11655-016-2531-0

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Evaluation of the potential inhibitory activity of a combination of L. acidophilus, L. rhamnosus and L. sporogenes on Helicobacter pylori: A randomized double-blind placebo-controlled clinical trial

Updated：2021-08-27

- Evaluation of the potential inhibitory activity of a combination of L. acidophilus, L. rhamnosus and L. sporogenes on Helicobacter pylori: A randomized double-blind placebo-controlled clinical trial
- Chinese Journal of Integrative Medicine Vol. 23, Issue 3, Pages: 176-182(2017)
- Affiliations：
  
  1. Institute of Medicine, Chung Shan Medical University, Taichung,Taiwan,China
  2. Department of Pharmacy, Chung Shan Medical University Hospital, Taichung,Taiwan,China
  3. Department of Medicine, Chung Shan Medical University, Taichung,Taiwan,China
  4. Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Taichung,Taiwan,China
  5. Department of Statistics and Informatics Science, Providence University,, China,China
  6. Department of Applied Cosmetology, National Tainan Junior College of Nursing,Taiwan,China
  7. Division of Hepatogastroenterology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung,Taiwan,China
- Author bio：
- Funds：
  
  Supported by the Ministry of Economic Affairs (Contract No. 9931201029-7-1), Taiwan, China and Chung Shan Medical University (Protocol No.: CSMU-G1040001)
- DOI：10.1007/s11655-016-2531-0
  CLC：
- Published：2017，
  
  Published Online：19 October 2016，
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Lee, CY., Shih, HC., Yu, MC. et al. Evaluation of the potential inhibitory activity of a combination of L. acidophilus, L. rhamnosus and L. sporogenes on Helicobacter pylori: A randomized double-blind placebo-controlled clinical trial., Chin. J. Integr. Med. 23, 176–182 (2017). https://doi.org/10.1007/s11655-016-2531-0

Chien-Ying Lee, Hung-Che Shih, Min-Chien Yu, et al. Evaluation of the potential inhibitory activity of a combination of L. acidophilus, L. rhamnosus and L. sporogenes on Helicobacter pylori: A randomized double-blind placebo-controlled clinical trial. [J]. Chinese Journal of Integrative Medicine 23(3):176-182(2017)
Lee, CY., Shih, HC., Yu, MC. et al. Evaluation of the potential inhibitory activity of a combination of L. acidophilus, L. rhamnosus and L. sporogenes on Helicobacter pylori: A randomized double-blind placebo-controlled clinical trial., Chin. J. Integr. Med. 23, 176–182 (2017). https://doi.org/10.1007/s11655-016-2531-0 DOI：

Chien-Ying Lee, Hung-Che Shih, Min-Chien Yu, et al. Evaluation of the potential inhibitory activity of a combination of L. acidophilus, L. rhamnosus and L. sporogenes on Helicobacter pylori: A randomized double-blind placebo-controlled clinical trial. [J]. Chinese Journal of Integrative Medicine 23(3):176-182(2017) DOI： 10.1007/s11655-016-2531-0.

摘要

To investigate whether three strains of probiotics

L. acidophilus

L. rhamnosus

and L. sporogenes

had signifificant inhibitive effects on Helicobacter pylori (H. pylori). This is a 4-week

randomly assigned

parallel-group

doubled-blind

and placebo-controlled study. Fifty patients with a positive H. pylori infection urea breath test (△UBT) result > 10% and without ulcer symptoms were randomized into a treatment group and a placebo group by a computer generated allocation sheet with 1:1. These subjects took one capsule of probiotics or placebo twice daily. The primary measurement was the change in △UBT values. The △UBT values during the 4-week treatment period and the 2-week follow-up period were not signifificantly different between the treatment group and the placebo group

indicating that the inhibitive effects on H. pylori were comparable between both groups. The monocyte count (%) was 5.77±1.11 in the treatment group versus 5.09±1.12 in the placebo group (P=0.044)

and the basophile count was 0.55±0.32 in the treatment group versus 0.36±0.23 in the placebo group (P=0.024) at week 2 of the treatment period

both of which reached statistical signifificance. The monocyte count was 5.75±1.26 in the treatment group and 4.72±0.99 in the placebo group at the end of the follow-up period (P=0.003). There was no signifificant inhibitive effects of the three probiotic strains (L. acidophilus

L. rhamnosus

and L. sporogenes) on H. pylori. Probiotics can not play the same role as antibiotics in the eradication of H. pylori

the role of probiotics is likely to be important as adjuvant to the triple or quadruple therapy for H. pylori

especially in resistance cases.

Abstract

To investigate whether three strains of probiotics

L. acidophilus

L. rhamnosus

and L. sporogenes

had signifificant inhibitive effects on Helicobacter pylori (H. pylori). This is a 4-week

randomly assigned

parallel-group

doubled-blind

indicating that the inhibitive effects on H. pylori were comparable between both groups. The monocyte count (%) was 5.77±1.11 in the treatment group versus 5.09±1.12 in the placebo group (P=0.044)

and the basophile count was 0.55±0.32 in the treatment group versus 0.36±0.23 in the placebo group (P=0.024) at week 2 of the treatment period

L. rhamnosus

and L. sporogenes) on H. pylori. Probiotics can not play the same role as antibiotics in the eradication of H. pylori

the role of probiotics is likely to be important as adjuvant to the triple or quadruple therapy for H. pylori

especially in resistance cases.

关键词

probioticsHelicobacter pyloriurea breath testrandomized double-blind placebo-controlled trial

Keywords

probioticsHelicobacter pyloriurea breath testrandomized double-blind placebo-controlled trial

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Department of Tradional Chinese Medicine and Integrated Tradional Chinese and Western Medicine, Peking University First Hospital

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Department of Gastroenterology, Peking University First Hospital

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