Short-term efficacy of treating hepatitis B virus-related acute-on-chronic liver failure based on cold pattern differentiation with hot herbs: A randomized controlled trial

Yu-ming Guo; Feng-yi Li; Man Gong; Lin Zhang; Jia-bo Wang; Xiao-he Xiao; Jun Li; Yan-ling Zhao; Li-fu Wang; Xiao-feng Zhang

doi:10.1007/s11655-016-2582-2

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Short-term efficacy of treating hepatitis B virus-related acute-on-chronic liver failure based on cold pattern differentiation with hot herbs: A randomized controlled trial

Updated：2021-08-27

- Short-term efficacy of treating hepatitis B virus-related acute-on-chronic liver failure based on cold pattern differentiation with hot herbs: A randomized controlled trial
- Chinese Journal of Integrative Medicine Vol. 22, Issue 8, Pages: 573-580(2016)
- Affiliations：
  
  1. China Military Institute of Chinese Materia Medica, Military Hospital,Beijing,China,302
  2. Treatment and Research Center for Infectious Diseases, Military Hospital,Beijing,China,302
  3. Integrative Medical Center for Liver Diseases, Military Hospital,Beijing,China,302
  4. Medical Affairs, Novartis Pharma China,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Ministry of Science and Technology of China, through its National Key Projects for Basic Research (No. 2007CB512607), and National Eleventh Five-year Great Science and Technology Project (No. 2008ZX10005-007)
- DOI：10.1007/s11655-016-2582-2
  CLC：
- Published：2016，
  
  Published Online：24 May 2016，
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Guo, Ym., Li, Fy., Gong, M. et al. Short-term efficacy of treating hepatitis B virus-related acute-on-chronic liver failure based on cold pattern differentiation with hot herbs: A randomized controlled trial., Chin. J. Integr. Med. 22, 573–580 (2016). https://doi.org/10.1007/s11655-016-2582-2

Yu-ming Guo, Feng-yi Li, Man Gong, et al. Short-term efficacy of treating hepatitis B virus-related acute-on-chronic liver failure based on cold pattern differentiation with hot herbs: A randomized controlled trial. [J]. Chinese Journal of Integrative Medicine 22(8):573-580(2016)
Guo, Ym., Li, Fy., Gong, M. et al. Short-term efficacy of treating hepatitis B virus-related acute-on-chronic liver failure based on cold pattern differentiation with hot herbs: A randomized controlled trial., Chin. J. Integr. Med. 22, 573–580 (2016). https://doi.org/10.1007/s11655-016-2582-2 DOI：

Yu-ming Guo, Feng-yi Li, Man Gong, et al. Short-term efficacy of treating hepatitis B virus-related acute-on-chronic liver failure based on cold pattern differentiation with hot herbs: A randomized controlled trial. [J]. Chinese Journal of Integrative Medicine 22(8):573-580(2016) DOI： 10.1007/s11655-016-2582-2.

摘要

To evaluate the clinical efficacy and safety of Yinchen Zhufu Decoction (茵陈术附汤

YCZFD) in the treatment of acute-on-chronic liver failure caused by hepatitis B virus (HBV-ACLF) with cold pattern in Chinese medicine (CM). This is a multi-center randomized controlled trial of integrative treatment of CM and Western medicine (WM) for the management of HBV-ACLF patients. A total of 200 HBV-ACLF patients with cold pattern were equally randomly assigned to receive YCZFD and WM (integrative treatment) or WM conventional therapy alone respectively for 4 weeks. The primary end point was the mortality for HBV-ACLF patients. Secondary outcome measures included Model for End-Stage Liver disease (MELD) score

liver biochemical function

coagulation function and complications. Adverse events during treatment were reported. The mortality was decreased 14.28% in the integrative treatment group compared with WM group (χ2 =6.156

P=0.013). The integrative treatment was found to signifificantly improve the MELD score (t=2.353

P=0.020). There were statistically signifificant differences in aspartate transaminase

total bilirubin

indirect bilirubin

direct bilirubin and prothrombin time between the two groups (P<0.05 or P<0.01). The complications of ascites (χ2=9.033

P=0.003) and spontaneous bacteria peritonitis (χ2=4.194

P=0.041) were improved signifificantly in the integrative treatment group. No serious adverse event was reported. The integrative treatment of CM and WM was effective and safe for HBV-ACLF patients with cold pattern in CM. The Chinese therapeutic principle “treating cold pattern with hot herbs” remains valuable to the clinical therapy. (Trial registration No. ChiCTR-TRC-10000766)

Abstract

To evaluate the clinical efficacy and safety of Yinchen Zhufu Decoction (茵陈术附汤

liver biochemical function

coagulation function and complications. Adverse events during treatment were reported. The mortality was decreased 14.28% in the integrative treatment group compared with WM group (χ2 =6.156

P=0.013). The integrative treatment was found to signifificantly improve the MELD score (t=2.353

P=0.020). There were statistically signifificant differences in aspartate transaminase

total bilirubin

indirect bilirubin

direct bilirubin and prothrombin time between the two groups (P<0.05 or P<0.01). The complications of ascites (χ2=9.033

P=0.003) and spontaneous bacteria peritonitis (χ2=4.194

关键词

hepatitis B virus-related acute-on-chronic liver failuremortalityChinese Medicinecold patternYinchen Zhufu Decoction

Keywords

hepatitis B virus-related acute-on-chronic liver failuremortalityChinese Medicinecold patternYinchen Zhufu Decoction

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