Effects of Shenfu Injection (参附注射液) on cerebral metabolism in a porcine model of cardiac arrest

Qin Yin; Cai-jun Wu; Jun Yang; Chen-chen Hang; Chun-sheng Li

doi:10.1007/s11655-016-2616-9

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Effects of Shenfu Injection (参附注射液) on cerebral metabolism in a porcine model of cardiac arrest

Updated：2021-08-27

- Effects of Shenfu Injection (参附注射液) on cerebral metabolism in a porcine model of cardiac arrest
- Chinese Journal of Integrative Medicine Vol. 23, Issue 1, Pages: 33-39(2017)
- Affiliations：
  
  1. Department of Emergency, the First Affiliated Hospital of Nanchang University,Nanchang,China
  2. Department of Emergency, Beijing Chaoyang Hospital, Capital Medical University, Beijing Key Laboratory of Cardiopulmonarycerebral Resuscitation,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-016-2616-9
  CLC：
- Published：2017，
  
  Published Online：10 September 2016，
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Yin, Q., Wu, Cj., Yang, J. et al. Effects of Shenfu Injection (参附注射液) on cerebral metabolism in a porcine model of cardiac arrest., Chin. J. Integr. Med. 23, 33–39 (2017). https://doi.org/10.1007/s11655-016-2616-9

Qin Yin, Cai-jun Wu, Jun Yang, et al. Effects of Shenfu Injection (参附注射液) on cerebral metabolism in a porcine model of cardiac arrest. [J]. Chinese Journal of Integrative Medicine 23(1):33-39(2017)
Yin, Q., Wu, Cj., Yang, J. et al. Effects of Shenfu Injection (参附注射液) on cerebral metabolism in a porcine model of cardiac arrest., Chin. J. Integr. Med. 23, 33–39 (2017). https://doi.org/10.1007/s11655-016-2616-9 DOI：

Qin Yin, Cai-jun Wu, Jun Yang, et al. Effects of Shenfu Injection (参附注射液) on cerebral metabolism in a porcine model of cardiac arrest. [J]. Chinese Journal of Integrative Medicine 23(1):33-39(2017) DOI： 10.1007/s11655-016-2616-9.

摘要

To investigate the effects of Shenfu Injection (参附注射液

SFI) on cerebral metabolism in a porcine model of cardiac arrest (CA). Thirty Wuzhishan minipigs were randomly assigned to the control group (n=6)

epinephrine group (EP group

n=12) and Sfigroup (n=12). After 8 min of untreated ventricular fifibrillation (VF)

pigs in the EP group or Sfigroup were administered with either EP (0.02 mg/kg) or Sfi(1.0 mL/kg)

respectively. After successful resuscitation

cerebrospinal fluid (CSF) levels of glucose

pyruvate

lactate

glutamate and glycerol were measured at 1

12 and 24 h after recover from spontaneous circulation (ROSC). In addition

neurologic defificit score (NDS) was calculated at 24 h after ROSC. Surviving pigs were killed at 24 h after ROSC

and the brain tissue was obtained for ultra-microstructure examination. Compared with the EP group

CSF glucose and pyruvate levels were higher (all P<0.01)

and lactate levels were lower in the Sfigroup (P<0.01). Meanwhile

CSF glutamate and glycerol levels in the Sfigroup were lower in comparison to the EP group (all P<0.05). In addition

Sfidecreased NDS at 24 h after ROSC (P<0.01)

and alleviated the histopathological damage of the brain. Sficould alleviate brain injury after CA

which may be associated with improving cerebral metabolism.

Abstract

To investigate the effects of Shenfu Injection (参附注射液

SFI) on cerebral metabolism in a porcine model of cardiac arrest (CA). Thirty Wuzhishan minipigs were randomly assigned to the control group (n=6)

epinephrine group (EP group

n=12) and Sfigroup (n=12). After 8 min of untreated ventricular fifibrillation (VF)

pigs in the EP group or Sfigroup were administered with either EP (0.02 mg/kg) or Sfi(1.0 mL/kg)

respectively. After successful resuscitation

cerebrospinal fluid (CSF) levels of glucose

pyruvate

lactate

glutamate and glycerol were measured at 1

12 and 24 h after recover from spontaneous circulation (ROSC). In addition

neurologic defificit score (NDS) was calculated at 24 h after ROSC. Surviving pigs were killed at 24 h after ROSC

and the brain tissue was obtained for ultra-microstructure examination. Compared with the EP group

CSF glucose and pyruvate levels were higher (all P<0.01)

and lactate levels were lower in the Sfigroup (P<0.01). Meanwhile

CSF glutamate and glycerol levels in the Sfigroup were lower in comparison to the EP group (all P<0.05). In addition

Sfidecreased NDS at 24 h after ROSC (P<0.01)

and alleviated the histopathological damage of the brain. Sficould alleviate brain injury after CA

which may be associated with improving cerebral metabolism.

关键词

Shenfu Injectioncerebral metabolismcardiac arrest

Keywords

Shenfu Injectioncerebral metabolismcardiac arrest

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Related Institution

Emergency Department of Beijing Chaoyang Hospital, Capital Medical University

Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University

Department of Emergency, Beijing Chao-Yang Hospital, Capital Medical University

Department of Hyperbaric Oxygen, Beijing Chao-Yang Hospital, Capital Medical University

Department of Anesthesiology, The First Affiliated Hospital, Chongqing University of Medical Sciences

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