Chinese medicine for idiopathic Parkinson’s disease: A meta analysis of randomized controlled trials

Wei Wei; Hai-yong Chen; Wen Fan; Shui-fen Ye; Yi-hui Xu; Jing Cai

doi:10.1007/s11655-016-2618-7

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Chinese medicine for idiopathic Parkinson’s disease: A meta analysis of randomized controlled trials

Updated：2021-08-27

- Chinese medicine for idiopathic Parkinson’s disease: A meta analysis of randomized controlled trials
- Chinese Journal of Integrative Medicine Vol. 23, Issue 1, Pages: 55-61(2017)
- Affiliations：
  
  1. College of Integrative Medicine, Fujian University of Traditional Chinese Medicine,Fuzhou,China
  2. Hospital of Chinese People’s Liberation Army, Xiangyang,Hubei Province,China,477
  3. School of Chinese Medicine, the University of Hong Kong,Hong Kong SAR,China
  4. Xiamen Haicang Hospital,Fujian Province,Xiamen,China
  5. Longyan First Hospital Affiliated to Fujian Medical University,Fujian Province,Longyan,China
  6. Second People’s Hospital, Fujian University of Traditional Chinese Medicine,Fuzhou,China
- Author bio：
- Funds：
  
  Supported Chen Keji Integrative Foundation (CKJ2015004), Foundation of Fujian University of Traditional Chinese Medicine (X2014010-xueke), and the Scientific Research Fund of the National Health and Family Planning Commission of the People’s Republic of China (No.WKJ-FJ-38)
- DOI：10.1007/s11655-016-2618-7
  CLC：
- Published：2017，
  
  Published Online：27 October 2016，
Scan for full text
Wei, W., Chen, Hy., Fan, W. et al. Chinese medicine for idiopathic Parkinson’s disease: A meta analysis of randomized controlled trials., Chin. J. Integr. Med. 23, 55–61 (2017). https://doi.org/10.1007/s11655-016-2618-7

Wei Wei, Hai-yong Chen, Wen Fan, et al. Chinese medicine for idiopathic Parkinson’s disease: A meta analysis of randomized controlled trials. [J]. Chinese Journal of Integrative Medicine 23(1):55-61(2017)
Wei, W., Chen, Hy., Fan, W. et al. Chinese medicine for idiopathic Parkinson’s disease: A meta analysis of randomized controlled trials., Chin. J. Integr. Med. 23, 55–61 (2017). https://doi.org/10.1007/s11655-016-2618-7 DOI：

Wei Wei, Hai-yong Chen, Wen Fan, et al. Chinese medicine for idiopathic Parkinson’s disease: A meta analysis of randomized controlled trials. [J]. Chinese Journal of Integrative Medicine 23(1):55-61(2017) DOI： 10.1007/s11655-016-2618-7.

摘要

To evaluate the efficacy of Chinese medicine (CM) adjunct to conventional medications for idiopathic Parkinson’s disease (PD). Electronic English and Chinese databases including PubMed

Cochrane Library

Web of Science

Chinese Medical Current Contents

China National Knowledge Infrastructure

China Science and Technology Journal Database

Wanfang Med Database

and Traditional Chinese Medical Database System were used for key words searching in a highly sensitive search strategy. The extracted data was analyzed by the Review Manager 5.0. Twelve trials involving 869 participants were included in the meta-analysis. Unified PD Rating Scale (UPDRS) I

III

IV scores and UPDRS V–IV total scores were used to be the primary outcomes

Parkinson Disease Question-39 (PDQ-39) and Scores of Chinese Medical Symptoms were the secondary outcomes. CM adjunct therapy had greater improvement in UPDRS I [2 trials; standardized mean difference (SMD)–0.40

95% confidence interval (CI)–0.71 to–0.09; Z=2.49 (P=0.01)]

II [5 trials; SMD–0.47

95% CI–0.69 to–0.25; Z=4.20 (P<0.01)]

III [5 trials; SMD-0.35

95% CI–0.57 to–0.13; Z=3.16 (P=0.002)]

IV scores [3 trials; SMD-0.32

95% CI–0.60 to–0.03; Z=2.17 (P=0.03)]

UPDRS I–IV total scores [7 trials; SMD-0.36

95%CI–0.53 to–0.20; Z=4.24 (P<0.05)]. PDQ-39 and Chinese medical symptoms compared to the conventional medication only. CM adjunct therapy has potential therapeutic benefits by decreasing UPDRS scores and reducing adverse effect.

Abstract

To evaluate the efficacy of Chinese medicine (CM) adjunct to conventional medications for idiopathic Parkinson’s disease (PD). Electronic English and Chinese databases including PubMed

Cochrane Library

Web of Science

Chinese Medical Current Contents

China National Knowledge Infrastructure

China Science and Technology Journal Database

Wanfang Med Database

III

IV scores and UPDRS V–IV total scores were used to be the primary outcomes

95% confidence interval (CI)–0.71 to–0.09; Z=2.49 (P=0.01)]

II [5 trials; SMD–0.47

95% CI–0.69 to–0.25; Z=4.20 (P<0.01)]

III [5 trials; SMD-0.35

95% CI–0.57 to–0.13; Z=3.16 (P=0.002)]

IV scores [3 trials; SMD-0.32

95% CI–0.60 to–0.03; Z=2.17 (P=0.03)]

UPDRS I–IV total scores [7 trials; SMD-0.36

关键词

Parkinson’s diseaseChinese Medicinemeta analysisrandomized controlled trials

Keywords

Parkinson’s diseaseChinese Medicinemeta analysisrandomized controlled trials

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