Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille

Shen-shen Guo; Meng-yue Ren; Shuai Song; Ping Wei; Jia-bo Luo

doi:10.1007/s11655-016-2646-3

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Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille

Updated：2021-08-27

- Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille
- Chinese Journal of Integrative Medicine Vol. 23, Issue 2, Pages: 138-145(2017)
- Affiliations：
  
  1. School of Traditional Chinese Medicine, Southern Medical University,Guangzhou,China
  2. Guangdong Province Key Laboratory of Chinese Medicine Pharmaceutics, Southern Medical University,Guangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-016-2646-3
  CLC：
- Published：2017，
  
  Published Online：7 March 2017，
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Guo, Ss., Ren, My., Song, S. et al. Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille., Chin. J. Integr. Med. 23, 138–145 (2017). https://doi.org/10.1007/s11655-016-2646-3

Shen-shen Guo, Meng-yue Ren, Shuai Song, et al. Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille. [J]. Chinese Journal of Integrative Medicine 23(2):138-145(2017)
Guo, Ss., Ren, My., Song, S. et al. Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille., Chin. J. Integr. Med. 23, 138–145 (2017). https://doi.org/10.1007/s11655-016-2646-3 DOI：

Shen-shen Guo, Meng-yue Ren, Shuai Song, et al. Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille. [J]. Chinese Journal of Integrative Medicine 23(2):138-145(2017) DOI： 10.1007/s11655-016-2646-3.

摘要

To assess the antinociceptive and anti-inflammatory properties of the aqueous extract of Armadillidium vulgare (AV). The antinociceptive effect of AV (400

600 and 800 mg/kg) was investigated in mice using the acetic acid-induced writhing

formalin-induced nociceptive

and hot plate tests. Phlogogen-induced paw edema using carrageenan

dextran

or compound 48/80 as phlogogen was used as inflammatory models to evaluate AV's anti-inflammatory effect. Additionally

the bioactive substances glucosamine (GLcN) and taurine in AV were determined using high-performance liquid chromatography. Oral treatment of the mice with AV (600 and 800 mg/kg) significantly reduced the number of writhes in the acetic acid-induced writhing test (P<0.01) but not the hot plate test (P>0.05). All doses tested significantly inhibited paw-withdrawal during the second phase of the formalin-induced nociceptive model (P<0.01). AV demonstrated a strong anti-inflammatory effect in all those inflammatory models (P<0.05). AV has antinociceptive and anti-inflammatory effects

providing scientific evidence of the efficacy of its traditional use in pain treatment. Furthermore

GLcN and taurine contribute

at least in part

to the anti-inflammatory activity of AV.

Abstract

To assess the antinociceptive and anti-inflammatory properties of the aqueous extract of Armadillidium vulgare (AV). The antinociceptive effect of AV (400

600 and 800 mg/kg) was investigated in mice using the acetic acid-induced writhing

formalin-induced nociceptive

and hot plate tests. Phlogogen-induced paw edema using carrageenan

dextran

or compound 48/80 as phlogogen was used as inflammatory models to evaluate AV's anti-inflammatory effect. Additionally

providing scientific evidence of the efficacy of its traditional use in pain treatment. Furthermore

GLcN and taurine contribute

at least in part

to the anti-inflammatory activity of AV.

关键词

Armadillidium vulgaremedicinal animalnociceptioninflammationglucosamine

Keywords

Armadillidium vulgaremedicinal animalnociceptioninflammationglucosamine

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Related Institution

Xiyuan Hospital, China Academy of Chinese Medical Sciences

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College

Department of Pharmacology, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University

Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine

Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine

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