Effect of compound Zhuye Shigao Granule (复方竹叶石膏 颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial

Li-juan Wang; Jun-zhang Lu; Bo-ning Cai; Ming-wei Li; Bao-lin Qu

doi:10.1007/s11655-016-2652-5

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Effect of compound Zhuye Shigao Granule (复方竹叶石膏颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial

Updated：2021-08-27

- Effect of compound Zhuye Shigao Granule (复方竹叶石膏颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial
- Chinese Journal of Integrative Medicine Vol. 23, Issue 2, Pages: 98-104(2017)
- Affiliations：
  
  1. Department of Chinese Medicine, Chinese PLA General Hospital,Beijing,China
  2. Department of Radiation Therapy, Chinese PLA General Hospital,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81373543) and Clinical Research Support Fund of the PLA General Hospital (No. 2013FC-ZHCG-1002)
- DOI：10.1007/s11655-016-2652-5
  CLC：
- Published：2017，
  
  Published Online：29 December 2016，
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Wang, Lj., Lu, Jz., Cai, Bn. et al. Effect of compound Zhuye Shigao Granule (复方竹叶石膏颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial., Chin. J. Integr. Med. 23, 98–104 (2017). https://doi.org/10.1007/s11655-016-2652-5

Li-juan Wang, Jun-zhang Lu, Bo-ning Cai, et al. Effect of compound Zhuye Shigao Granule (复方竹叶石膏颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial. [J]. Chinese Journal of Integrative Medicine 23(2):98-104(2017)
Wang, Lj., Lu, Jz., Cai, Bn. et al. Effect of compound Zhuye Shigao Granule (复方竹叶石膏颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial., Chin. J. Integr. Med. 23, 98–104 (2017). https://doi.org/10.1007/s11655-016-2652-5 DOI：

Li-juan Wang, Jun-zhang Lu, Bo-ning Cai, et al. Effect of compound Zhuye Shigao Granule (复方竹叶石膏颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial. [J]. Chinese Journal of Integrative Medicine 23(2):98-104(2017) DOI： 10.1007/s11655-016-2652-5.

摘要

To observe the efficacy and safety of the Chinese medicine (CM) Compound Zhuye Shigao Granule (复方竹叶石膏颗粒

CZSG) on acute radiation-induced esophagitis (ARIE) in cancer patients. In a blinded

randomized

Kangfuxin Solution (康复新液

KFX)-controlled

single-centre clinical trial

120 patients with lung

esophagus or mediastinal cancer were prospectively enrolled and assigned to the treatment group (60 cases) and control group (60 cases) by the random number table method. All patients received concurrent or sequential radiotherapy (2 Gy per day

5 times per week

for 4 weeks) and were treated for 4 weeks since the radiation therapy. Patients in the treatment group were given 12 mg CZSG orally

thrice daily

while patients in the control group were given 10 mL KFX orally

thrice daily. The major indicators were observed

including the incidence and grade of esophagitis

time of occurrence and duration. Minor indicators were changes of CM symptoms

weight and Karnofsky Performance Status (KPS) Scale during 4 weeks from the beginning

recorded once a week. Blood routine examination and hepatorenal function were detected at the 2nd and 4th weeks. The incidence and grade of ARIE were significantly decreased in the treatment group compared with the control group (P<0.05). CZSG appeared to significantly delay the time of ARIE occurrence and reduce the duration compared with KFX (P<0.05). The scores of CM symptoms

KPS and weight were improved significantly in the treatment group compared with the control group (P<0.05). There were no blood routine and hepatorenal function abnormal or obvious side-effects in both groups. Hemoglobin was improved and neutrophil and interleukin 6 were decreased in both groups after 4-week treatment compared with before treatment (P<0.05)

and there was no significant difference between the two groups (P>0.05). CZSG can decrease the incidence and grade of ARIE

delay the time of occurrence

reduce duration and alleviate the damage of ARIE. It is safe and effective in the prevention and cure of ARIE.

Abstract

To observe the efficacy and safety of the Chinese medicine (CM) Compound Zhuye Shigao Granule (复方竹叶石膏颗粒

CZSG) on acute radiation-induced esophagitis (ARIE) in cancer patients. In a blinded

randomized

Kangfuxin Solution (康复新液

KFX)-controlled

single-centre clinical trial

120 patients with lung

5 times per week

for 4 weeks) and were treated for 4 weeks since the radiation therapy. Patients in the treatment group were given 12 mg CZSG orally

thrice daily

while patients in the control group were given 10 mL KFX orally

thrice daily. The major indicators were observed

including the incidence and grade of esophagitis

time of occurrence and duration. Minor indicators were changes of CM symptoms

weight and Karnofsky Performance Status (KPS) Scale during 4 weeks from the beginning

and there was no significant difference between the two groups (P>0.05). CZSG can decrease the incidence and grade of ARIE

delay the time of occurrence

reduce duration and alleviate the damage of ARIE. It is safe and effective in the prevention and cure of ARIE.

关键词

Compound Zhuye Shigao Granuleacute radiation-induced esophagitisradiotherapyChinese Medicinecancer

Keywords

Compound Zhuye Shigao Granuleacute radiation-induced esophagitisradiotherapyChinese Medicinecancer

references

Diana M, Shriram J. Radiation esophagitis. Arch Pathol Lab Med 2015;139:826–830.

Palma DA, Senan S, Oberije C, Belderbos J, de Dios NR, Bradley JD, et al. Predicting esophagitis after chemoradiation therapy for non-small cell lung cancer: an individual patient data meta-analysis. Int J Radiat Oncol Biol Phys 2013;87:690–696.

Auperin A, Le C, Rolland E. Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J Clin Oncol 2010;28:2181–2190.

Topkan E, Yavuz MN, Onal C, Yavuz AA. Prevention of acute radiation-induced esophagitis with glutamine in nonsmall cell lung cancer patients treated with radiotherapy: evaluation of clinical and dosimetric parameters. Lung Cancer 2009;63:393–399.

Bar-Ad V, Ohri N, Werner-Wasik M. Esophagitis, treatmentrelated toxicity in non-small cell lung cancer. Rev Recent Clin Trials 2012;7:31–35.

Choi GB, Shin JH, Song HY. Fluoroscopically guided balloon dilation for patients with esophageal stricture after radiation treatment. J Vasc Interv Radiol 2005;16:1705–1710.

Feng M, Smith DE, Normolle DP. A phase I clinical and pharmacology study using amifostine as a radioprotector in dose-escalated whole liver radiation therapy. Int J Radiat Oncol Biol Phys 2012;83:1441–1447.

Lu JZ, Zhao H, Liu Y, Feng LC. Clinical study on prevention and treatment for acute radiation esophagitis by Modified Lophatheri and Gypsi Fibrosi Decoction. China J Tradit Chin Med Pharm (Chin) 2010;25:59–62.

Lu JZ, Wang C, Cao XT, Yang MH, Zhao H, Liu Y. Effect of Zhuye Shigao Granule on tumor necrosis factor-a and interleukins serum protein levels in rats with radiation esophagitis. J Tradit Chin Med (Chin) 2014;34:338–341.

Lu JZ, Zhao L, Ren JP, Cao XT. Preventive and therapeutic effects of Chinese herbal medicine Compound Zhuye Shigao Granule in rats with radiation-induced esophagitis. J Chin Integr Med (Chin) 2011;9:435–441.

China Food and Drug Administration. Good clinical practice. [S/OL]. (2003-08-06) [2014-09-17] Available at: http://www.sfda.gov.cn/WS01/CL0053/24473.html.

Cox JD, Stez J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995;31:1341–1346.

Zhao H, Xie P, Li X, Zhu W, Sun XD, Sun XR, et al. A prospective phase II trial of EGCG in treatment of acute radiation-induced esophagitis for stage III lung cancer. Radiother Oncol 2015;114:351–356.

Sun YD. Effects of Huisheng Koufuye in prevention and treatment of acute radiation-induced esophagitis. World Chin J Digestol 2014;22:3019.

Zhang Z, Xu J, Zhou T, Yi Y, Li H. Risk factors of radiationinduced acute esophagitis in non-small cell lung cancer patients treated with concomitant chemoradiotherapy. Radiat Oncol 2014;9:54–61.

Lu JZ, Wang C, Yang MH, Zhao H, Liu Y, Cao XT. Effect of Modified Zhuye Shigao Decoction and its components on preventing radiation esophagitis of rats. Chin J Integr Med 2014;20:462–467.

Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L. Iron deficiency anaemia. Lancet 2015;387:907–916.

Lin HL, Li GJ, Wu JZ. Effect of aluminum phosphate gel and Kangfuxin on esophageal pathology and IL-8 and PGE2 expressions in a rat model of reflux esophagitis. J South Med Uni 2015;35:573–577.

Wu SB, Bai HM, Chen JZ, Zhang CB, Bao SX. Effect of Kangfuxin Liquid in the treatment of 60 cases with radiation esophagitis. Jinlin Med (Chin) 2010;31:5730–5731.

Qiu XL, Yang M, Xie XL, Lai J, Chen SW. In vivo/in vitro evaluation of Kangfuxin Colon Targeting Capsules. China J Chin Mater Med (Chin) 2007;32:1644–1647.

Luo TZ, Gao MT, Ma FF, Liu GM, Zhang CJ. Research advances in phmacological action and clinical application of Periplaneta americana. Agricult Sci Technol 2012;13:888–892.

Jiang Y, Wang X, Jin C, Chen X, Li J, Wu Z, et al. Inhibitory effect of Periplaneta americana extract on 3LL lung cancer in mice. Chin J Lung Cancer (Chin) 2006;9:488–491.

Lin J, Wei L, Shen A, Cai Q, Xu W, Li H, et al. Hedyotis diffusa Willd extract suppresses Sonic hedgehog signaling leading to the inhibition of colorectal cancer angiogenesis. Int J Oncol 2013;42:651–656.

Dai ZJ, Liu XX, Ji ZZ, Liu L, Kang HF, Wang XJ, et al. The effect-enhancing and toxicity-reducing action of the extract of Herba Scutellariae barbatae for chemotherapy in hepatoma H22 tumor-bearing mice. J Tradit Chin Med 2008;28:205–210.

Tang Q, Shao M, Wang Y, Zhao H, Fan C, Huang X, et al. Simultaneous determination of 10 bioactive components of Lophatherum gracile Brongn by HPLC-DAD. J Chromatogr Sci 2015;53:963–967.

You Q, Ma ZC, Wang YG, Hu DH, Liang QD, Xiao CR, et al. Panax ginseng inhibits intestinal absorption of toxic Aconitum carmichaeli alkaloids in vitro. Chin J Integr Med 2015. DOI: 10.1007/s11655-015-2282-3

Zu G, Wang H, Wang J, Dou Y, Zhao W, Sun Y. Rhizoma Pinelliae trypsin inhibitor separation, purification and inhibitory activity on the proliferation of BGC-823 gastric adenocarcinoma cells. Exp Ther Med 2014;8:248–254.

Hu YC, Xie YM, Yang W, Wang YY, Wang LX, Tang H, et al. Clinical characteristics research of Shenmai Injection treating tumor based on hospital information system in real world. China J Chin Mater Med (Chin) 2014;39:3509–3513.

Yu JY, Ha JY, Kim KM, Jung YS, Jung JC, Oh S. Antiinflammatory activities of licorice extract and its active compounds, glycyrrhizicacid, liquiritin and liquiritigenin in BV2 cells and mice liver. Molecules 2015;20:13041–13054.

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