Synchronous dynamic research on respiratory and intestinal microflora of chronic bronchitis rat model

Xiu-li Zheng; Yu Yang; Bao-jia Wang; Ju Wang; Hong-qu Tang

doi:10.1007/s11655-016-2731-7

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Synchronous dynamic research on respiratory and intestinal microflora of chronic bronchitis rat model

Updated：2021-08-27

- Synchronous dynamic research on respiratory and intestinal microflora of chronic bronchitis rat model
- Chinese Journal of Integrative Medicine Vol. 23, Issue 3, Pages: 196-200(2017)
- Affiliations：
  
  College of Basic Medicine, Chengdu University of Traditional Chinese Medicine,Chengdu,China
- Author bio：
- Funds：
  
  Supported by the National Basic Research Program of China (973 Program, No. 2009CB522706)
- DOI：10.1007/s11655-016-2731-7
  CLC：
- Published：2017，
  
  Published Online：24 October 2016，
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Zheng, Xl., Yang, Y., Wang, Bj. et al. Synchronous dynamic research on respiratory and intestinal microflora of chronic bronchitis rat model., Chin. J. Integr. Med. 23, 196–200 (2017). https://doi.org/10.1007/s11655-016-2731-7

Xiu-li Zheng, Yu Yang, Bao-jia Wang, et al. Synchronous dynamic research on respiratory and intestinal microflora of chronic bronchitis rat model. [J]. Chinese Journal of Integrative Medicine 23(3):196-200(2017)
Zheng, Xl., Yang, Y., Wang, Bj. et al. Synchronous dynamic research on respiratory and intestinal microflora of chronic bronchitis rat model., Chin. J. Integr. Med. 23, 196–200 (2017). https://doi.org/10.1007/s11655-016-2731-7 DOI：

Xiu-li Zheng, Yu Yang, Bao-jia Wang, et al. Synchronous dynamic research on respiratory and intestinal microflora of chronic bronchitis rat model. [J]. Chinese Journal of Integrative Medicine 23(3):196-200(2017) DOI： 10.1007/s11655-016-2731-7.

摘要

To investigate the mechanism of the Chinese medicine theory that Fei (Lung) and Dachang (Large Intestine) are exteriorly and interiorly related via synchronous observation on the dynamic changes of the respiratory and intestinal microflora. Forty specific pathogen free Sprague-Dawley rats were selected and randomly divided into blank (10 rats) and chronic bronchitis model groups (30 rats). The blank group rats were put into the smoke-free environment and the model group rats were put into the smoke environment in order to establish pulmonary disease (chronic bronchitis) model. Then the corresponding changes of the respiratory and intestinal microflflora of the model on 20th

50th and 70th days were synchronously observed. The respiratory tract microflflora showed an increase in the total aerobic and Staphylococcus aureus and reduced anaerobic amount signifificantly on 20th day in the respiratory tract microflflora (P<0.05 or 0.01). On 50th day

total aerobic

total anaerobic amount and bififidobacterium signifificantly increased (P<0.05). On 70th day

Staphylococcus aureus reduced and lactobacillus increased signifificantly (P<0.01). The intestinal microflflora showed an increase in the total aerobic

Clostridium perfringens

enterobacter and enterococcus significantly increased on 20th day (P<0.05 or 0.01). Staphylococcus aureus on 50th day increased significantly (P<0.05). Total aerobic and enterococcus increased

total anaerobic and Clostridium perfringens reduced signifificantly on 70th day (P<0.05 or 0.01). The microecosystem of respiratory tract and intestine of rat model during the pathological process showed a dynamic disorder

indicating an interaction between the lung and large intestine which may be one of the connotations as they exteriorly and interiorly related.

Abstract

total aerobic

total anaerobic amount and bififidobacterium signifificantly increased (P<0.05). On 70th day

Staphylococcus aureus reduced and lactobacillus increased signifificantly (P<0.01). The intestinal microflflora showed an increase in the total aerobic

Clostridium perfringens

enterobacter and enterococcus significantly increased on 20th day (P<0.05 or 0.01). Staphylococcus aureus on 50th day increased significantly (P<0.05). Total aerobic and enterococcus increased

indicating an interaction between the lung and large intestine which may be one of the connotations as they exteriorly and interiorly related.

关键词

respiratoryintestinalpulmonary diseasemicrofloramicro-ecologyChronic BronchitisChinese medicine theory

Keywords

respiratoryintestinalpulmonary diseasemicrofloramicro-ecologyChronic BronchitisChinese medicine theory

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