Shenfu Injection (参附注射液) inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock

Yan-yan Jin; Hai Gao; Xin-yong Zhang; Hui Ai; Xiao-lin Zhu; Jing Wang

doi:10.1007/s11655-016-2749-x

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Shenfu Injection (参附注射液) inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock

Updated：2021-08-27

- Shenfu Injection (参附注射液) inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock
- Chinese Journal of Integrative Medicine Vol. 23, Issue 3, Pages: 170-175(2017)
- Affiliations：
  
  Emergency and Critical Care Center, Beijing Anzhen Hospital, Capital Medical University,Beijing,China
- Author bio：
- Funds：
  
  Supported by Beijing Chinese Medicine Technology Development Surfaces Subject of Special Funds (No. JJ2013-19)
- DOI：10.1007/s11655-016-2749-x
  CLC：
- Published：2017，
  
  Published Online：27 December 2016，
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Jin, Yy., Gao, H., Zhang, Xy. et al. Shenfu Injection (参附注射液) inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock., Chin. J. Integr. Med. 23, 170–175 (2017). https://doi.org/10.1007/s11655-016-2749-x

Yan-yan Jin, Hai Gao, Xin-yong Zhang, et al. Shenfu Injection (参附注射液) inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock. [J]. Chinese Journal of Integrative Medicine 23(3):170-175(2017)
Jin, Yy., Gao, H., Zhang, Xy. et al. Shenfu Injection (参附注射液) inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock., Chin. J. Integr. Med. 23, 170–175 (2017). https://doi.org/10.1007/s11655-016-2749-x DOI：

Yan-yan Jin, Hai Gao, Xin-yong Zhang, et al. Shenfu Injection (参附注射液) inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock. [J]. Chinese Journal of Integrative Medicine 23(3):170-175(2017) DOI： 10.1007/s11655-016-2749-x.

摘要

To investigate the effect of Shenfu Injection (参附注射液

SFI) on inflammatory factors in patients with acute myocardial infarction complicated by cardiogenic shock (CS) treated with and intra-aortic balloon pump (IABP). This study enrolled 60 patients with ST-segment elevation myocardial infarction (STEMI) complicated by CS. Patients underwent IABP and emergency percutaneous coronary intervention (PCI) were randomly divided into two groups by random number table with 30 cases in each group

one given Sfitreatment (100 mL/24 h)

one not. The two groups were then compared in a clinical setting for left ventricular function

biochemical indicators and Inflammatory factors

including C-reactive proteins (CRP)

interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α). Major adverse cardiac and cerebrovascular events (MACCE) events were compared between patients of the two groups both in-hospital and in follow-ups. The IABP support treatment times of patients in the IABP+Sfigroup were signifificantly shorter than the IABP group (52.87±28.84 vs. 87.45±87.31

P=0.047). In the patients of the IABP+Sfigroup

the CRP peak appeared in 24 h after PCI operation. The CRP peak in the patients of the IABP+Sfigroup was signifificantly lower than that in the IABP group (31.27±3.93 vs. 34.62±3.47

P=0.001). The increases in range of TNF-α in the patients of the IABP+Sfigroup were signifificantly lower than those of the IABP group (182.29±22.79 vs. 195.54±12.02

P=0.007). The increases in range of IL-1 in the patients of the IABP+Sfigroup were signifificantly lower than those of the IABP group (214.98±29.22 vs. 228.60±7.03

P=0.019). The amplitude elevated TNF-α 72 h after admission was an independent risk factor of in-hospital MACCE events (OR 0.973

95% CI 0.890–0.987

P=0.014) in patients with STEMI and CS. Patients with STEMI complicated by CS treated by IABP and Sfihad a reduced inflammatory reaction

a reduced dependence of CS on IABP and shortened the course of disease.

Abstract

To investigate the effect of Shenfu Injection (参附注射液

one given Sfitreatment (100 mL/24 h)

one not. The two groups were then compared in a clinical setting for left ventricular function

biochemical indicators and Inflammatory factors

including C-reactive proteins (CRP)

P=0.047). In the patients of the IABP+Sfigroup

the CRP peak appeared in 24 h after PCI operation. The CRP peak in the patients of the IABP+Sfigroup was signifificantly lower than that in the IABP group (31.27±3.93 vs. 34.62±3.47

P=0.001). The increases in range of TNF-α in the patients of the IABP+Sfigroup were signifificantly lower than those of the IABP group (182.29±22.79 vs. 195.54±12.02

P=0.007). The increases in range of IL-1 in the patients of the IABP+Sfigroup were signifificantly lower than those of the IABP group (214.98±29.22 vs. 228.60±7.03

P=0.019). The amplitude elevated TNF-α 72 h after admission was an independent risk factor of in-hospital MACCE events (OR 0.973

95% CI 0.890–0.987

P=0.014) in patients with STEMI and CS. Patients with STEMI complicated by CS treated by IABP and Sfihad a reduced inflammatory reaction

a reduced dependence of CS on IABP and shortened the course of disease.

关键词

inflflammatory factorcardiac shockintra-aortic balloon pumpChinese MedicineShenfu Injection

Keywords

inflflammatory factorcardiac shockintra-aortic balloon pumpChinese MedicineShenfu Injection

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