Xuebijing Injection (血必净注射液) increases early survival rate by alleviating pulmonary vasopermeability in rats subjected to severe burns

Yue-long Dai; Jing-yuan Li; Hui-ying Bai; Si Liu; Yong-qi Dou; Sen Hu

doi:10.1007/s11655-017-2407-y

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Xuebijing Injection (血必净注射液) increases early survival rate by alleviating pulmonary vasopermeability in rats subjected to severe burns

Updated：2021-08-27

- Xuebijing Injection (血必净注射液) increases early survival rate by alleviating pulmonary vasopermeability in rats subjected to severe burns
- Chinese Journal of Integrative Medicine Vol. 23, Issue 9, Pages: 703-708(2017)
- Affiliations：
  
  1. Medical School of Chinese PLA, Chinese PLA General Hospital,Beijing,China
  2. Chinese People’s Armed Police Force Academy,Hebei Province,Langfang,China
  3. Research Department, the Tianjin Chase Sun Pharmaceutical Co., Ltd.,Tianjin,China
  4. Department of Pathology, Langfang Traditional Chinese Medicine Hospital,Hebei Province,Langfang,China
  5. Department of Traditional Chinese Medicine, Chinese PLA General Hospital,Beijing,China
  6. Burns Institute, First Hospital Affiliated to PLA General Hospital,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81471872);Conflict of Interests;The authors declare that they have no conflict of interests.;Author Contributions;Dai YL and Hu S designed the experiments. Li JY, Bai HY and Liu S provided technical support. Dai YL, Bai HY, Dou YQ and Hu S conducted the experiments. Dai YL and Dou YQ performed the analysis drafted the manuscript. All authors read and approved the final version of the manuscript.
- DOI：10.1007/s11655-017-2407-y
  CLC：
- Published：2017，
  
  Published Online：11 May 2017，
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Dai, Yl., Li, Jy., Bai, Hy. et al. Xuebijing Injection (血必净注射液) increases early survival rate by alleviating pulmonary vasopermeability in rats subjected to severe burns., Chin. J. Integr. Med. 23, 703–708 (2017). https://doi.org/10.1007/s11655-017-2407-y

Yue-long Dai, Jing-yuan Li, Hui-ying Bai, et al. Xuebijing Injection (血必净注射液) increases early survival rate by alleviating pulmonary vasopermeability in rats subjected to severe burns. [J]. Chinese Journal of Integrative Medicine 23(9):703-708(2017)
Dai, Yl., Li, Jy., Bai, Hy. et al. Xuebijing Injection (血必净注射液) increases early survival rate by alleviating pulmonary vasopermeability in rats subjected to severe burns., Chin. J. Integr. Med. 23, 703–708 (2017). https://doi.org/10.1007/s11655-017-2407-y DOI：

Yue-long Dai, Jing-yuan Li, Hui-ying Bai, et al. Xuebijing Injection (血必净注射液) increases early survival rate by alleviating pulmonary vasopermeability in rats subjected to severe burns. [J]. Chinese Journal of Integrative Medicine 23(9):703-708(2017) DOI： 10.1007/s11655-017-2407-y.

摘要

To investigate the effects of Xuebijing Injection (血必净注射液

XBJ) on survival rate and pulmonary vasopermeability in a rat model of severe scald injury. Rats were divided into two experiments: experiment 1 was monitored for 12 h post-injury for survival analysis after severe burns; in experiment 2

rats were killed for determination of pulmonary vascular permeability and pro-inflflammatory mediators. In both experiments

rats were subject to third-degree 50% total body surface area (TBSA) burns or sham injury followed by XBJ or normal saline (NS) treatment. In addition

rat pulmonary microvascular endothelium cells (PMECs) were pretreated with either XBJ or phosphate buffer saline (PBS)

and then subjected to sham serum or scald serum stimulation for 2 or 6 h

followed by transwell examination for the permeability of PMECs. Meanwhile

pro-inflflammatory mediators in PMECs culture supernatant were also investigated. The average survival time in the scald+XBJ group was 582.1±21.2 min

which was signifificantly longer than that in the scald + NS group (345.8±25.4 min

P<0.01). Plasma levels of tumor necrosis factor-alpha (TNF-α)

E-selectin

interleukin-6 (IL-6)

vascular permeability and water content of lung tissues were signifificantly increased in animals after severe burns (P<0.01). However

administration of XBJ signifificantly decreased these levels in plasma and lung tissue. In in vitro cell experiments

XBJ markedly attenuated permeability in PMECs monolayer and reduced the levels of TNF-α

IL-6 and soluble E-selectin after stimulation with scald serum (P<0.01). XBJ increases early survival rate by alleviating pulmonary vasopermeability and inhibiting pro-inflflammatory mediators in rats subjected to lethal scald injury. XBJ may be a potent drug in treatment of severe burns.

Abstract