Effect of Qingfei Mixture (清肺合剂) on pediatric mycoplasma pneumoniae pneumonia with phlegm heat obstructing Fei (Lung) syndrome

Ai-jun Yang; Kun Xi; Yan-qing Yao; Ying-xue Ding; Li-jun Yang; Hong Cui

doi:10.1007/s11655-017-2409-9

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Effect of Qingfei Mixture (清肺合剂) on pediatric mycoplasma pneumoniae pneumonia with phlegm heat obstructing Fei (Lung) syndrome

Updated：2021-08-27

- Effect of Qingfei Mixture (清肺合剂) on pediatric mycoplasma pneumoniae pneumonia with phlegm heat obstructing Fei (Lung) syndrome
- Chinese Journal of Integrative Medicine Vol. 23, Issue 9, Pages: 681-688(2017)
- Affiliations：
  
  Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University,Beijing,China
- Author bio：
- Funds：
  
  Supported by Beijing Municipal Science and Technology Commission (No. Z151100003815020), the Capital Fund for the Development of Medical Science (TCM Board. No. SF-2007-III-23), and the Traditional Chinese Medicine Science and Technology Development Fund Project of Beijing (No. JJ2012-09);Conflict of Interest;The authors declare that there is no conflict of interest regarding the publication of this article.;Author Contributions;Cui H and Yang AJ conceived and designed the experiments;Yang AJ conducted the experiment and wrote the manuscript;Xi K conducted the animal experiment and Yao YQ performed the clinical observation;Ding YX and Yang LJ participated in the experimental operation and writing. All authors read and approved the final manuscript.
- DOI：10.1007/s11655-017-2409-9
  CLC：
- Published：2017，
  
  Published Online：2 September 2017，
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Yang, Aj., Xi, K., Yao, Yq. et al. Effect of Qingfei Mixture (清肺合剂) on pediatric mycoplasma pneumoniae pneumonia with phlegm heat obstructing Fei (Lung) syndrome., Chin. J. Integr. Med. 23, 681–688 (2017). https://doi.org/10.1007/s11655-017-2409-9

Ai-jun Yang, Kun Xi, Yan-qing Yao, et al. Effect of Qingfei Mixture (清肺合剂) on pediatric mycoplasma pneumoniae pneumonia with phlegm heat obstructing Fei (Lung) syndrome. [J]. Chinese Journal of Integrative Medicine 23(9):681-688(2017)
Yang, Aj., Xi, K., Yao, Yq. et al. Effect of Qingfei Mixture (清肺合剂) on pediatric mycoplasma pneumoniae pneumonia with phlegm heat obstructing Fei (Lung) syndrome., Chin. J. Integr. Med. 23, 681–688 (2017). https://doi.org/10.1007/s11655-017-2409-9 DOI：

Ai-jun Yang, Kun Xi, Yan-qing Yao, et al. Effect of Qingfei Mixture (清肺合剂) on pediatric mycoplasma pneumoniae pneumonia with phlegm heat obstructing Fei (Lung) syndrome. [J]. Chinese Journal of Integrative Medicine 23(9):681-688(2017) DOI： 10.1007/s11655-017-2409-9.

摘要

To explore the effect and mechanism of Qingfei Mixture (清肺合剂)

a Chinese medicine

in treating mycoplasma pneumonia (MP) in MP patients and rat model A total of 46 MP children with phlegm heat obstructing Fei (Lung) syndrome were randomly assigned to two groups by the method of random number table

with 23 children in each group. The control group was treated with intravenous infusion of azithromycin; the treatment group received intravenous infusion of azithromycin and oral administration of Qingfei Mixture. The treatment course was 7 days. Major symptoms and minor symptoms were observed and scored before and after treatments. A rat model of MP was also established. A total of 120 wistar rats were randomly divided into 5 groups: a normal group

infection group

Qingfei Mixture treatment group

azithromycin treatment group

and Qingfei Mixture + azithromycin treatment group. Each group contained 24 rats

from which every 6 were euthanatized 1

7 and 14 days after infection. MP DNA in pulmonary tissue homogenates was detected using real-time fluorescence quantitative polymerase chain reaction. Pathology was assessed after hematoxylin (HE) staining and lung tissue pathology scores were determined in pulmonary tissue. Transmission electron microscopic detection and electronic image analysis were performed on lung tissue 3 days after infection. Interleukin (IL)-17 was detected in serum using enzymelinked immunosorbent assay (ELISA) 7 days after infection. In the clinical study

both control and the treatment group showed improved results on removing symptoms of phlegm heat syndrome compared to the control group (P<0.05). In animal experiments

On the 7th day after MP infection

as detected by electron microscopy

the pulmonary capillary basement membranes of the azithromycin + Qingfei Mixture treatment group were much thinner than those of the azithromycin or Qingfei mixture treatment groups (P<0.05). The level of serum IL-17 in the azithromycin + Qingfei Mixture treatment group was lower than that in the azithromycin or Qingfei Mixture groups (P<0.01). Both Qingfei Mixture and azithromycin have therapeutic effects on mycoplasma pneumoniae pneumonia

but the combination of both agents had the greatest effect.

Abstract

To explore the effect and mechanism of Qingfei Mixture (清肺合剂)

a Chinese medicine

infection group

Qingfei Mixture treatment group

azithromycin treatment group

and Qingfei Mixture + azithromycin treatment group. Each group contained 24 rats

from which every 6 were euthanatized 1

both control and the treatment group showed improved results on removing symptoms of phlegm heat syndrome compared to the control group (P<0.05). In animal experiments

On the 7th day after MP infection

as detected by electron microscopy

but the combination of both agents had the greatest effect.

关键词

mycoplasma pneumoniaepneumoniaazithromycinQingfei MixturechildrenChinese Medicine

Keywords

mycoplasma pneumoniaepneumoniaazithromycinQingfei MixturechildrenChinese Medicine

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