Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases

Yan Liu; Li-yun He; Tian-cai Wen; Shi-yan Yan; Wen-jing Bai; Bao-yan Liu

doi:10.1007/s11655-017-2420-1

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Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases

Updated：2021-08-27

- Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases
- Chinese Journal of Integrative Medicine Vol. 24, Issue 2, Pages: 87-93(2018)
- Affiliations：
  
  Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Nation Health and Family Planning Commission of China (No. 2012ZX10005009), Fundamental Research Funds for the Central Public Welfare Research Institutes (No. Z0474) and National Natural Science Foundation of China (No. 81503679)
- DOI：10.1007/s11655-017-2420-1
  CLC：
- Published：2018，
  
  Published Online：17 October 2017，
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Liu, Y., He, Ly., Wen, Tc. et al. Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases., Chin. J. Integr. Med. 24, 87–93 (2018). https://doi.org/10.1007/s11655-017-2420-1

Yan Liu, Li-yun He, Tian-cai Wen, et al. Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases. [J]. Chinese Journal of Integrative Medicine 24(2):87-93(2018)
Liu, Y., He, Ly., Wen, Tc. et al. Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases., Chin. J. Integr. Med. 24, 87–93 (2018). https://doi.org/10.1007/s11655-017-2420-1 DOI：

Yan Liu, Li-yun He, Tian-cai Wen, et al. Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases. [J]. Chinese Journal of Integrative Medicine 24(2):87-93(2018) DOI： 10.1007/s11655-017-2420-1.

摘要

To determine whether patterns of enterovirus 71 (EV71)-associated hand

foot

and mouth disease (HFMD) were classified based on symptoms and signs

and explore whether individual characteristics were correlated with membership in particular pattern. Symptom-based latent class analysis (LCA) was used to determine whether patterns of EV71-HFMD existed in a sample of 433 cases from a clinical data warehouse system. Logistic regression was then performed to explore whether demographic

and laboratory data were associated with pattern membership. LCA demonstrated a two-subgroup solution with an optimal fit

deduced according to the Bayesian Information Criterion minima. Hot pattern (59.1% of all patients) was characterized by a very high fever and high endorsement rates for classical HFMD symptoms (i.e.

rash on the extremities

blisters

and oral mucosa lesions). Non-hot pattern (40.9% of all patients) was characterized by classical HFMD symptoms. The multiple logistic regression results suggest that white blood cell counts and aspartate transaminase were positively correlated with the hot pattern (adjust odds ratio=1.07

95% confidence interval: 1.006–1.115; adjust odds ratio=1.051

95% confidence interval: 1.019–1.084; respectively). LCA on reported symptoms and signs in a retrospective study allowed different subgroups with meaningful clinical correlates to be defined. These findings provide evidence for targeted prevention and treatment interventions.

Abstract

To determine whether patterns of enterovirus 71 (EV71)-associated hand

foot

and mouth disease (HFMD) were classified based on symptoms and signs

and laboratory data were associated with pattern membership. LCA demonstrated a two-subgroup solution with an optimal fit

deduced according to the Bayesian Information Criterion minima. Hot pattern (59.1% of all patients) was characterized by a very high fever and high endorsement rates for classical HFMD symptoms (i.e.

rash on the extremities

blisters

95% confidence interval: 1.006–1.115; adjust odds ratio=1.051

关键词

handfoot and mouth diseasepattern classificationenterovirus AhumanChinese Medicine

Keywords

handfoot and mouth diseasepattern classificationenterovirus AhumanChinese Medicine

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Department of Integrated Traditional Chinese Medicine and Western Medicine, Beijing Youan Hospital Affiliated to Capital Medical University

Department of Communicable Diseases, Children’s Hospital of Hunan Province

Department of Pediatrics, Guangzhou Medical Center for Women and Children

Department of Pediatrics, First Hospital Affiliated to Guangxi Medical University

Department of Internal Medicine, Handan Maternal and Child Health Hospital

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