Efficacy of Modified Wuzhuyu Decoction Granule (加减吴茱萸汤 颗粒剂) for Migraine Patients with Cold and Stasis Obstructing Meridian Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

Hong-wei Liu; Yi-huai Zou; Ke-gang Cao; Li-hua Yu; Yong Zhang; Cai-hong Fu; Da-yong Ma

doi:10.1007/s11655-017-2547-5

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Efficacy of Modified Wuzhuyu Decoction Granule (加减吴茱萸汤颗粒剂) for Migraine Patients with Cold and Stasis Obstructing Meridian Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

Updated：2021-08-27

- Efficacy of Modified Wuzhuyu Decoction Granule (加减吴茱萸汤颗粒剂) for Migraine Patients with Cold and Stasis Obstructing Meridian Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
- Chinese Journal of Integrative Medicine Vol. 24, Issue 6, Pages: 409-414(2018)
- Affiliations：
  
  1. Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine,Beijing,China
  2. Department of Neurology, Beijing Hospital of Traditional Chinese Medicine in Shunyi District,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-017-2547-5
  CLC：
- Published：2018，
  
  Published Online：25 July 2017，
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Liu, Hw., Zou, Yh., Cao, Kg. et al. Efficacy of Modified Wuzhuyu Decoction Granule (加减吴茱萸汤颗粒剂) for Migraine Patients with Cold and Stasis Obstructing Meridian Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial., Chin. J. Integr. Med. 24, 409–414 (2018). https://doi.org/10.1007/s11655-017-2547-5

Hong-wei Liu, Yi-huai Zou, Ke-gang Cao, et al. Efficacy of Modified Wuzhuyu Decoction Granule (加减吴茱萸汤颗粒剂) for Migraine Patients with Cold and Stasis Obstructing Meridian Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. [J]. Chinese Journal of Integrative Medicine 24(6):409-414(2018)
Liu, Hw., Zou, Yh., Cao, Kg. et al. Efficacy of Modified Wuzhuyu Decoction Granule (加减吴茱萸汤颗粒剂) for Migraine Patients with Cold and Stasis Obstructing Meridian Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial., Chin. J. Integr. Med. 24, 409–414 (2018). https://doi.org/10.1007/s11655-017-2547-5 DOI：

Hong-wei Liu, Yi-huai Zou, Ke-gang Cao, et al. Efficacy of Modified Wuzhuyu Decoction Granule (加减吴茱萸汤颗粒剂) for Migraine Patients with Cold and Stasis Obstructing Meridian Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. [J]. Chinese Journal of Integrative Medicine 24(6):409-414(2018) DOI： 10.1007/s11655-017-2547-5.

摘要

To study the efficacy of modified Wuzhuyu Decoction Granule (加减吴茱萸汤颗粒

MWDG) in the treatment of migraine patients with cold and stasis obstructing meridian syndrome. This study was a randomized

double-blind

placebo-controlled trial. A total of 78 migraine patients with cold and stasis obstructing meridian syndrome were recruited and randomly assigned by a ratio of 2:1 into a treatment group (51 cases) and a placebo group (27 cases). Patients in the treatment group were treated with MWDG while placebo granules were applied in the control group. The treatment course lasted for 12 weeks with a follow-up of 4 weeks. The primary outcome measures included frequency and days of migraine attacks and the secondary outcome measures were analgesics consumption and visual analogue scale (VAS) scores. All outcome assessments were conducted respectively at baseline

the 4th

8th and 12th week

and the end of follow-up. In the treatment group

significant decrease in frequency of migraine attacks were observed since the 4th week and that of analgesics consumption since the 8th week (both P<0.05). While

in the placebo group

significant decrease in frequency of migraine attacks were observed since the 8th week and that of analgesics consumption since the 12th week (both P<0.05). No significant decrease in days of migraine attacks and VAS scores of migraine pain were observed in both groups. Between the two groups

there were significant differences in VAS scores and intensity of pain appeared in the 8th week (P<0.05). However

no significant differences were found in days and frequency of migraine attacks and analgesics consumption (P>0.05). MWDG was probably effective in the treatment of migraine especially for alleviating pain intensity. Furthermore

MWDG could reduce the frequency of migraine attacks and analgesics consumption sooner than the placebo.

Abstract

To study the efficacy of modified Wuzhuyu Decoction Granule (加减吴茱萸汤颗粒

MWDG) in the treatment of migraine patients with cold and stasis obstructing meridian syndrome. This study was a randomized

double-blind

the 4th

8th and 12th week

and the end of follow-up. In the treatment group

significant decrease in frequency of migraine attacks were observed since the 4th week and that of analgesics consumption since the 8th week (both P<0.05). While

in the placebo group

there were significant differences in VAS scores and intensity of pain appeared in the 8th week (P<0.05). However

MWDG could reduce the frequency of migraine attacks and analgesics consumption sooner than the placebo.

关键词

modified Wuzhuyu Decoction GranuleMigrainecold and stasis obstructing meridian syndromerandomized controlled trialChinese Medicine

Keywords

modified Wuzhuyu Decoction GranuleMigrainecold and stasis obstructing meridian syndromerandomized controlled trialChinese Medicine

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