Liver-adipose tissue crosstalk: A key player in the pathogenesis of glucolipid metabolic disease

De-wei Ye; Xiang-lu Rong; Ai-min Xu; Jiao Guo

doi:10.1007/s11655-017-2810-4

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Liver-adipose tissue crosstalk: A key player in the pathogenesis of glucolipid metabolic disease

Updated：2021-08-27

- Liver-adipose tissue crosstalk: A key player in the pathogenesis of glucolipid metabolic disease
- Chinese Journal of Integrative Medicine Vol. 23, Issue 6, Pages: 410-414(2017)
- Affiliations：
  
  1. Guangdong Research Center of Metabolic Diseases of Integrated Western and Chinese Medicine, Guangdong Pharmaceutical University,Guangzhou,China
  2. Joint Laboratory between Guangdong and Hong Kong on Metabolic Disease, Guangdong Pharmaceutical University,Guangzhou,China
  3. State Key Laboratory of Pharmaceutical Biotechnology, the University of Hong Kong,Hong Kong SAR,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-017-2810-4
  CLC：
- Published：2017，
  
  Published Online：10 August 2017，
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Ye, Dw., Rong, Xl., Xu, Am. et al. Liver-adipose tissue crosstalk: A key player in the pathogenesis of glucolipid metabolic disease., Chin. J. Integr. Med. 23, 410–414 (2017). https://doi.org/10.1007/s11655-017-2810-4

De-wei Ye, Xiang-lu Rong, Ai-min Xu, et al. Liver-adipose tissue crosstalk: A key player in the pathogenesis of glucolipid metabolic disease. [J]. Chinese Journal of Integrative Medicine 23(6):410-414(2017)
Ye, Dw., Rong, Xl., Xu, Am. et al. Liver-adipose tissue crosstalk: A key player in the pathogenesis of glucolipid metabolic disease., Chin. J. Integr. Med. 23, 410–414 (2017). https://doi.org/10.1007/s11655-017-2810-4 DOI：

De-wei Ye, Xiang-lu Rong, Ai-min Xu, et al. Liver-adipose tissue crosstalk: A key player in the pathogenesis of glucolipid metabolic disease. [J]. Chinese Journal of Integrative Medicine 23(6):410-414(2017) DOI： 10.1007/s11655-017-2810-4.

摘要

Glucolipid metabolic disease (GLMD)

a complex of interrelated disorders in glucose and lipid metabolism

has become one of the leading chronic diseases causing public and clinical problem worldwide. As the metabolism of lipid and glucose is a highly coordinated process under both physiological and diseased conditions

the impairment in the signals corresponding to the metabolism of either lipid or glucose represents the common mechanism underlying the pathogenesis of GLMD. The liver and adipose tissue are the major metabolic organs responsible for energy utilization and storage

respectively. This review article aims to summarize the current advances in the investigation of the functional roles and the underling mechanisms of the interplay between the liver and adipose tissue in the modulation of GLMD development. Fibroblast growth factor 21 (FGF21) and adiponectin represent the two major hormones secreted from the liver and adipose tissues

respectively. FGF21 exerts pleiotropic effects on regulating glucose and lipid homeostasis majorly through inducing the expression and secretion of adiponectin. Therefore

FGF21-adiponectin axis functions as the key mediator for the crosstalk between the liver and adipose tissue to exert the beneficial effects on the maintenance of the homeostasis of energy consumption. The liver- and adipose tissue-derived factors with pleiotropic effects on regulating of lipid and glucose metabolism function as the key mediator for the crosstalk between these two highly active metabolic organs

thereby coordinating the initiation and development of GLMD.

Abstract

Glucolipid metabolic disease (GLMD)

a complex of interrelated disorders in glucose and lipid metabolism

respectively. FGF21 exerts pleiotropic effects on regulating glucose and lipid homeostasis majorly through inducing the expression and secretion of adiponectin. Therefore

thereby coordinating the initiation and development of GLMD.

关键词

obesitytype 2 diabetes mellitusinsulin resistanceglucolipid metabolic diseaseChinese Medicine

Keywords

obesitytype 2 diabetes mellitusinsulin resistanceglucolipid metabolic diseaseChinese Medicine

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Related Institution

Guang’anmen Hospital, China Academy of Chinese Medical Sciences

Department of Pharmaceutical Sciences, Guru Jambheshwar, University of Science and Technology, Hisar

Department of Endocrinology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology

Department of Traditional Chinese Medicine, Tongji Medical College, Huazhong University of Science and Technology

Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine

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