Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups

Dongsoo Kim; Chang-Hwan Bae; Ye Lee Jun; Hyongjun Jeon; Sungtae Koo; Seungtae Kim

doi:10.1007/s11655-017-2827-8

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Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups

Updated：2021-08-27

- Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups
- Chinese Journal of Integrative Medicine Vol. 23, Issue 12, Pages: 943-947(2017)
- Affiliations：
  
  Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea
- Author bio：
- Funds：
  
  Supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. NRF- 2014R1A5A2009936)
- DOI：10.1007/s11655-017-2827-8
  CLC：
- Published：2017，
  
  Published Online：6 October 2017，
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Kim, D., Bae, CH., Jun, Y.L. et al. Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups., Chin. J. Integr. Med. 23, 943–947 (2017). https://doi.org/10.1007/s11655-017-2827-8

Dongsoo Kim, Chang-Hwan Bae, Ye Lee Jun, et al. Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups. [J]. Chinese Journal of Integrative Medicine 23(12):943-947(2017)
Kim, D., Bae, CH., Jun, Y.L. et al. Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups., Chin. J. Integr. Med. 23, 943–947 (2017). https://doi.org/10.1007/s11655-017-2827-8 DOI：

Dongsoo Kim, Chang-Hwan Bae, Ye Lee Jun, et al. Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups. [J]. Chinese Journal of Integrative Medicine 23(12):943-947(2017) DOI： 10.1007/s11655-017-2827-8.

摘要

To investigate the potential alleviating effects of acupuncture on maternal separation (MS)-induced changes in plasma pro-inflammatory cytokine levels of rat pups. On postnatal day 15

rat pups were randomly assigned to 4 groups (n=6 per group) using a random number table: normal

MS with acupuncture stimulation at Shenmen (HT 7) acupoint (MS+HT 7)

and MS with acupuncture stimulation at Chengshan (BL 57) acupoint (MS+BL 57) groups. Rat pups in the normal group were housed with their mothers under standard conditions; those in the MS

MS+HT 7 and MS+BL 57 groups were maternally separated and individually maintained. Acupuncture stimulation was performed at HT 7 or BL 57 acupoints once a day for 7 consecutive days. A tail suspension test was performed to measure immobility time of rats and the plasma was collected on postnatal day 21

then levels of corticosterone (CORT)

interleukin (IL)-1β

IL-6 and glial cell-derived neurotrophic factor (GDNF) in plasma were measured. Compared with the normal group

the immobility time and the plasma levels of CORT

IL-1β

IL-6 and GDNF in the MS group were significantly increased (P<0.05 or P<0.01). Compared with the MS group

the immobility time and the plasma levels of CORT

IL-1β

IL-6 and GDNF were significantly reduced in the MS+HT 7 group (P<0.05 or P<0.01). Moreover

the immobility time and plasma levels of IL-1β and IL-6 in the MS+HT 7 group were significantly lower than those in the MS+BL 57 group (P<0.05). Acupuncture stimulation at HT 7 can alleviate the behavioral impairment and changes of the cytokines by MS

indicating that acupuncture can help to relieve MS-induced depression.

Abstract

To investigate the potential alleviating effects of acupuncture on maternal separation (MS)-induced changes in plasma pro-inflammatory cytokine levels of rat pups. On postnatal day 15

rat pups were randomly assigned to 4 groups (n=6 per group) using a random number table: normal

MS with acupuncture stimulation at Shenmen (HT 7) acupoint (MS+HT 7)

and MS with acupuncture stimulation at Chengshan (BL 57) acupoint (MS+BL 57) groups. Rat pups in the normal group were housed with their mothers under standard conditions; those in the MS

then levels of corticosterone (CORT)

interleukin (IL)-1β

IL-6 and glial cell-derived neurotrophic factor (GDNF) in plasma were measured. Compared with the normal group

the immobility time and the plasma levels of CORT

IL-1β

IL-6 and GDNF in the MS group were significantly increased (P<0.05 or P<0.01). Compared with the MS group

the immobility time and the plasma levels of CORT

IL-1β

IL-6 and GDNF were significantly reduced in the MS+HT 7 group (P<0.05 or P<0.01). Moreover

indicating that acupuncture can help to relieve MS-induced depression.

关键词

acupuncturedepressionmaternal separationcytokineinterleukin-1βinterleukin-6Corticosteroneglial cell-derived neurotrophic factor

Keywords

acupuncturedepressionmaternal separationcytokineinterleukin-1βinterleukin-6Corticosteroneglial cell-derived neurotrophic factor

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