Beneficial Effect of Berberis amurensis Rupr. on Penile Erection

Rui Tan; Yun Jung Lee; Kyung Woo Cho; Dae Gill Kang; Ho Sub Lee

doi:10.1007/s11655-017-2920-z

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Beneficial Effect of Berberis amurensis Rupr. on Penile Erection

Updated：2021-08-27

- Beneficial Effect of Berberis amurensis Rupr. on Penile Erection
- Chinese Journal of Integrative Medicine Vol. 24, Issue 6, Pages: 448-454(2018)
- Affiliations：
  
  1. College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, Republic of Korea
  2. Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, Republic of Korea
  3. Brain Korea 21 Plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, Republic of Korea
- Author bio：
- Funds：
- DOI：10.1007/s11655-017-2920-z
  CLC：
- Published：2018，
  
  Published Online：15 January 2018，
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Tan, R., Lee, Y.J., Cho, K.W. et al. Beneficial Effect of Berberis amurensis Rupr. on Penile Erection., Chin. J. Integr. Med. 24, 448–454 (2018). https://doi.org/10.1007/s11655-017-2920-z

Rui Tan, Yun Jung Lee, Kyung Woo Cho, et al. Beneficial Effect of Berberis amurensis Rupr. on Penile Erection. [J]. Chinese Journal of Integrative Medicine 24(6):448-454(2018)
Tan, R., Lee, Y.J., Cho, K.W. et al. Beneficial Effect of Berberis amurensis Rupr. on Penile Erection., Chin. J. Integr. Med. 24, 448–454 (2018). https://doi.org/10.1007/s11655-017-2920-z DOI：

Rui Tan, Yun Jung Lee, Kyung Woo Cho, et al. Beneficial Effect of Berberis amurensis Rupr. on Penile Erection. [J]. Chinese Journal of Integrative Medicine 24(6):448-454(2018) DOI： 10.1007/s11655-017-2920-z.

摘要

To investigate whether the methanol extract of Berberis amurensis Rupr. (BAR) augments penile erection using in vitro and in vivo experiments. The ex vivo study used corpus cavernosum strips prepared from adult male New Zealand White rabbits. In in vivo studies for intracavernous pressure (ICP)

blood pressure

mean arterial pressure (MAP)

and increase of peak ICP were continuously monitored during electrical stimulation of Sprague-Dawley rats. Preconstricted with phenylephrine (PE) in isolated endotheliumintact rabbit corus cavernosum

BAR relaxed penile smooth muscle in a dose-dependent manner

which was inhibited by pretreatment with NG-nitro-L-arginine methyl ester (L-NAME)

a nitric oxide synthase inhibitor

and 1H-[1

4]-oxadiazole-[4

3-α]-quinoxalin-1-one

a soluble guanylyl cclase inhibitor. BAR significantly relaxed penile smooth muscles dose-dependently in ex vivo

and this was inhibited by pretreatment with L-NAME 1H-[1

4]-oxadiazole-[4

3-α]-quinoxalin-1-one. BAR-induced relaxation was significantly attenuated by pretreatment with tetraethylammonium (TEA

P<0.01)

a nonselective K+ channel blocker

4-aminopyridine (4-AP

P<0.01)

a voltage-dependent K+ channel blocker

and charybdotoxin (P<0.01)

a large and intermediate conductance Ca2+ sensitive-K+ channel blocker

respectively. BAR induced an increase in peak ICP

ICP/MAP ratio and area under the curve dose dependently. BAR augments penile erection via the nitric oxide/cyclic guanosine monophosphate system and Ca2+ sensitive-K+ (BKCa and IKCa) channels in the corpus cavernosum.

Abstract

blood pressure

mean arterial pressure (MAP)

and increase of peak ICP were continuously monitored during electrical stimulation of Sprague-Dawley rats. Preconstricted with phenylephrine (PE) in isolated endotheliumintact rabbit corus cavernosum

BAR relaxed penile smooth muscle in a dose-dependent manner

which was inhibited by pretreatment with NG-nitro-L-arginine methyl ester (L-NAME)

a nitric oxide synthase inhibitor

and 1H-[1

4]-oxadiazole-[4

3-α]-quinoxalin-1-one

a soluble guanylyl cclase inhibitor. BAR significantly relaxed penile smooth muscles dose-dependently in ex vivo

and this was inhibited by pretreatment with L-NAME 1H-[1

4]-oxadiazole-[4

3-α]-quinoxalin-1-one. BAR-induced relaxation was significantly attenuated by pretreatment with tetraethylammonium (TEA

P<0.01)

a nonselective K+ channel blocker

4-aminopyridine (4-AP

P<0.01)

a voltage-dependent K+ channel blocker

and charybdotoxin (P<0.01)

a large and intermediate conductance Ca2+ sensitive-K+ channel blocker

respectively. BAR induced an increase in peak ICP

关键词

penile erectionBerberis amurensis Rupr.Nitric Oxidecyclic guanosine monophosphateK+ channel

Keywords

penile erectionBerberis amurensis Rupr.Nitric Oxidecyclic guanosine monophosphateK+ channel

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Department of Hematology, the Affiliated Hospital of Guiyang Medical College

Key Laboratory of Basic Pharmacology of Guizhou and Department of Pharmacology, Zunyi Medical College

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Tianjin University of Traditional Chinese Medicine

The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

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