Objective:

2

To investigate the hemodynamic effect of Shen-Fu Injection (参附注射液

SFI) in early volume resuscitation treated septic shock patients by monitoring pulse indicator continuous cardiac output (PICCO).

Methods:

2

All septic shock patients admitted in the Intensive Care Unit of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 1st

2014 to December 31th

2015

were reviewed

and totally 65 were enrolled in this study. They were assigned to SFI group (33 cases) and control group (32 cases). All 65 patients underwent conventional treatment mainly including volume resuscitation

antibiotics and vasoactive drugs therapy. The patients of the SFI group received additional 100 mL of SFI intravenously every 12 h. In all 65 patients

the PICCO arterial catheter and vein catheter were implanted within 1 h after the diagnosis of septic shock. In the course of early volume resuscitation

hemodynamic data of patients were recorded by PICCO monitor at 0

12

and 24 h after the catheter implantation.

Results:

2

The hemodynamic indices of the two groups showed no significant differences at the beginning of 0 h (

P

>

0.05). At 12 and 24 h

the hemodynamic indices of SFI group were significantly improved in comparison with the control group (

P

<

0.05)

including cardiac index (CI)

global end diastolic volume index (GEDI)

mean arterial pressure (MAP) and heart rate (HR). In addition

there was no significant change of extra-vascular lung water index between the two groups (

P

>

0.05).

Conclusion:

2

SFI significantly improved hemodynamic indices such as CI

GEDI

MAP and HR in early volume resuscitation treated septic shock patients.