Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY-1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction

Jin-Woo Jung; Seung Hwan Jeon; Woong Jin Bae; Su Jin Kim; Mun Su Chung; Byung Il Yoon; Sae Woong Choi; U. Syn Ha; Sung Yeoun Hwang; Sae Woong Kim

doi:10.1007/s11655-017-2970-1

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Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY-1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction

Updated：2021-08-27

- Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY-1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction
- Chinese Journal of Integrative Medicine Vol. 24, Issue 9, Pages: 670-675(2018)
- Affiliations：
  
  1. Department of Urology, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea
  2. Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneungsi, Gangwon-do, Republic of Korea
  3. Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  4. Catholic Integrative Medicine Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  5. Korea Bio Medical Science Institute, Seoul, Republic of Korea
- Author bio：
- Funds：
  
  Supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (No. HI15C0099)
- DOI：10.1007/s11655-017-2970-1
  CLC：
- Published：2018，
  
  Published Online：21 December 2017，
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Jung, JW., Jeon, S.H., Bae, W.J. et al. Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY-1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction., Chin. J. Integr. Med. 24, 670–675 (2018). https://doi.org/10.1007/s11655-017-2970-1

Jin-Woo Jung, Seung Hwan Jeon, Woong Jin Bae, et al. Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY-1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction. [J]. Chinese Journal of Integrative Medicine 24(9):670-675(2018)
Jung, JW., Jeon, S.H., Bae, W.J. et al. Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY-1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction., Chin. J. Integr. Med. 24, 670–675 (2018). https://doi.org/10.1007/s11655-017-2970-1 DOI：

Jin-Woo Jung, Seung Hwan Jeon, Woong Jin Bae, et al. Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY-1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction. [J]. Chinese Journal of Integrative Medicine 24(9):670-675(2018) DOI： 10.1007/s11655-017-2970-1.

摘要

To investigate the anti-oxidative stress and preventive effect of modified Gongjin-dan (WSY-1075) in a detrusor underactivity rat model. Rats were randomly allocated to three groups: shamoperated (control)

bladder outlet obstruction-induced detrusor underactivity (BOO-DU)

and BOO-DU with WSY-1075 (WSY) groups. WSY-1075 was orally administrated to rats 200 mg daily for 2 weeks prior to the operation and 4 weeks after the operation. Bladder outlet obstruction was surgically induced in rats by ligation around the urethra avoiding total obstruction. Cystometrography was conducted on rats in each group for examination of bladders. Compared with the control group

bladder outlet obstruction led to a significant increase in oxidative stress with consequent changes to molecular composition

and decrease in maximal detrusor pressure (P<0.05). WSY-1075 treatment significantly suppressed oxidative stress and prevented degenerative and dysfunctional changes in bladder

as compared with BOO-DU group (P<0.05). WSY-1075 had beneficial effect on prevention of BOO-DU.

Abstract

bladder outlet obstruction-induced detrusor underactivity (BOO-DU)

bladder outlet obstruction led to a significant increase in oxidative stress with consequent changes to molecular composition

and decrease in maximal detrusor pressure (P<0.05). WSY-1075 treatment significantly suppressed oxidative stress and prevented degenerative and dysfunctional changes in bladder

as compared with BOO-DU group (P<0.05). WSY-1075 had beneficial effect on prevention of BOO-DU.

关键词

detrusor underactivityanti-oxidantherbal

Keywords

detrusor underactivityanti-oxidantherbal

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