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Ginkgo Leaf Extract and Dipyridamole Injection as Adjuvant Treatment for Angina Pectoris: A Meta-Analysis of 41 Randomized Controlled Trials
- Chinese Journal of Integrative Medicine Vol. 24, Issue 12, Pages: 930-937(2018)
- Affiliations：
Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine,Beijing,China
- Author bio：
- Funds：Supported by the National Natural Science Foundation of China (No. 81473547 and No. 81673829)
DOI：10.1007/s11655-018-2557-6
CLC：Published：2018，
Published Online：11 May 2018，
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Tan, D., Wu, Jr., Cui, Yy. et al. Ginkgo Leaf Extract and Dipyridamole Injection as Adjuvant Treatment for Angina Pectoris: A Meta-Analysis of 41 Randomized Controlled Trials., Chin. J. Integr. Med. 24, 930–937 (2018). https://doi.org/10.1007/s11655-018-2557-6
Di Tan, Jia-rui Wu, Ying-ying Cui, et al. Ginkgo Leaf Extract and Dipyridamole Injection as Adjuvant Treatment for Angina Pectoris: A Meta-Analysis of 41 Randomized Controlled Trials. [J]. Chinese Journal of Integrative Medicine 24(12):930-937(2018)
Tan, D., Wu, Jr., Cui, Yy. et al. Ginkgo Leaf Extract and Dipyridamole Injection as Adjuvant Treatment for Angina Pectoris: A Meta-Analysis of 41 Randomized Controlled Trials., Chin. J. Integr. Med. 24, 930–937 (2018). https://doi.org/10.1007/s11655-018-2557-6 DOI：
Di Tan, Jia-rui Wu, Ying-ying Cui, et al. Ginkgo Leaf Extract and Dipyridamole Injection as Adjuvant Treatment for Angina Pectoris: A Meta-Analysis of 41 Randomized Controlled Trials. [J]. Chinese Journal of Integrative Medicine 24(12):930-937(2018) DOI： 10.1007/s11655-018-2557-6.
摘要
To provide information about the effectiveness and safety of Ginkgo Leaf Extract and Dipyridamole Injection (GD) as one adjuvant therapy for treating angina pectoris (AP) and to evaluate the relevant randomized controlled trials (RCTs) with meta-analysis. RCTs concerning AP treated by GD were searched in China Biology Medicine Disc (SinoMed)
PubMed
the China National Knowledge Infrastructure Database (CNKI)
the Chinese Scientifific Journals Database (VIP)
Wanfang Database
Embase
and the Cochrane Library
from inception to February
2017. The Cochrane Risk Assessment Tool was adopted to assess the methodological quality of the RCTs. The Review Manager 5.3 software was utilized to conduct the meta-analysis. A total of 41 RCTs involving 4
462 patients were included in the meta-analysis. The results indicated that the combined use of GD and Western medicine (WM) against AP was associated with a higher total effective rate [risk ratio (RR)=1.25
95% confifidence interval (CI): 1.21–1.29
P<0.01]
total effective rate of electrocardiogram (RR=1.29
95% CI: 1.21–1.36
P<0.01). Additional
GD combined with WM could decrease the level of plasma viscosity [mean difference (MD)=–0.56
95% CI:–0
81 to–0.30
P<0.01]
fifibrinogen [MD=–1.02
95% CI:–1.50 to–0.54
P<0.01]
whole blood low shear viscosity [MD=–2.27
95% CI:–3.04 to–1.49
P<0.01]
and whole blood high shear viscosity (MD=–0.90
95% CI: 1.37 to–0.44
P<0.01). Comparing with receiving WM only
the combine use of GD and WM was associated with a better curative effect for patients with AP. Nevertheless
limited by the methodological quality of included RCTs more large-sample
multi-center RCTs were needed to confifirm our fifindings and provide further evidence for the clinical utility of GD.
Abstract
To provide information about the effectiveness and safety of Ginkgo Leaf Extract and Dipyridamole Injection (GD) as one adjuvant therapy for treating angina pectoris (AP) and to evaluate the relevant randomized controlled trials (RCTs) with meta-analysis. RCTs concerning AP treated by GD were searched in China Biology Medicine Disc (SinoMed)
PubMed
the China National Knowledge Infrastructure Database (CNKI)
the Chinese Scientifific Journals Database (VIP)
Wanfang Database
Embase
and the Cochrane Library
from inception to February
2017. The Cochrane Risk Assessment Tool was adopted to assess the methodological quality of the RCTs. The Review Manager 5.3 software was utilized to conduct the meta-analysis. A total of 41 RCTs involving 4
462 patients were included in the meta-analysis. The results indicated that the combined use of GD and Western medicine (WM) against AP was associated with a higher total effective rate [risk ratio (RR)=1.25
95% confifidence interval (CI): 1.21–1.29
P<0.01]
total effective rate of electrocardiogram (RR=1.29
95% CI: 1.21–1.36
P<0.01). Additional
GD combined with WM could decrease the level of plasma viscosity [mean difference (MD)=–0.56
95% CI:–0
81 to–0.30
P<0.01]
fifibrinogen [MD=–1.02
95% CI:–1.50 to–0.54
P<0.01]
whole blood low shear viscosity [MD=–2.27
95% CI:–3.04 to–1.49
P<0.01]
and whole blood high shear viscosity (MD=–0.90
95% CI: 1.37 to–0.44
P<0.01). Comparing with receiving WM only
the combine use of GD and WM was associated with a better curative effect for patients with AP. Nevertheless
limited by the methodological quality of included RCTs more large-sample
multi-center RCTs were needed to confifirm our fifindings and provide further evidence for the clinical utility of GD.
关键词
Ginkgo Leaf Extract and Dipyridamole Injectionangina pectorisrandomized controlled trialssystematic reviewmeta-analysis
Keywords
Ginkgo Leaf Extract and Dipyridamole Injectionangina pectorisrandomized controlled trialssystematic reviewmeta-analysis
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