Chinese Medicine for Alzheimer's Disease: A Meta-Analysis of Randomized Controlled Trials

Hang-kun Ma; Yue Liu; Bo Li; Ying Zhang; Lin-juan Sun; Feng-qin Xu

doi:10.1007/s11655-018-2567-4

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Chinese Medicine for Alzheimer's Disease: A Meta-Analysis of Randomized Controlled Trials

Updated：2021-08-27

- Chinese Medicine for Alzheimer's Disease: A Meta-Analysis of Randomized Controlled Trials
- Chinese Journal of Integrative Medicine Vol. 24, Issue 12, Pages: 938-943(2018)
- Affiliations：
  
  1. Geriatric Institution, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  2. Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  3. Good Clinical Practice, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  4. Internal Neurology Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China, Youth Found Project (No. 81503450)
- DOI：10.1007/s11655-018-2567-4
  CLC：
- Published：2018，
  
  Published Online：22 September 2018，
Scan for full text
Ma, Hk., Liu, Y., Li, B. et al. Chinese Medicine for Alzheimer's Disease: A Meta-Analysis of Randomized Controlled Trials., Chin. J. Integr. Med. 24, 938–943 (2018). https://doi.org/10.1007/s11655-018-2567-4

Hang-kun Ma, Yue Liu, Bo Li, et al. Chinese Medicine for Alzheimer's Disease: A Meta-Analysis of Randomized Controlled Trials. [J]. Chinese Journal of Integrative Medicine 24(12):938-943(2018)
Ma, Hk., Liu, Y., Li, B. et al. Chinese Medicine for Alzheimer's Disease: A Meta-Analysis of Randomized Controlled Trials., Chin. J. Integr. Med. 24, 938–943 (2018). https://doi.org/10.1007/s11655-018-2567-4 DOI：

Hang-kun Ma, Yue Liu, Bo Li, et al. Chinese Medicine for Alzheimer's Disease: A Meta-Analysis of Randomized Controlled Trials. [J]. Chinese Journal of Integrative Medicine 24(12):938-943(2018) DOI： 10.1007/s11655-018-2567-4.

摘要

To evaluate the effificacy of oral Chinese medicine (CM) in comparison with donepezil

a cholinesterase inhibitor (ChEI)

for the treatment of Alzheimer's disease (AD). Randomized controlled trials (RCTs) have been searched

and the effect of CM compared with donepezil in AD has been investigated. An electronic search of MEDLINE

Excerpta Medica Database (EMBASE)

Cochrane Library

Chinese Biological Medicine Database (CBMdisc)

and China National Knowledge Infrastructure (CNKI) to identify articles in English and Chinese from the inception of the database until October 18

2015. A modifified Jadad score (7-points) to judge the methodological quality of studies

comprehensive meta-analysis was performed with Cochrane Collaboration Revman 5.3. Dichotomous data were analyzed by relative risk (RR) with a 95% confifidence interval (CI)

while continuous variables were analyzed by using mean differences (MD) with 95% CI for effect size. Six studies involving 596 AD patients through Jadad assessment with low bias were included in the meta-analysis. No signifificant difference was observed in cognitive improvement and daily abilities of patients using the Mini Mental State Examination (MMSE) (MD: 0.69

95% CI:–0.17 to 1.56) and Activities of Daily Living (ADL) scale (MD: 0.94

95% CI:–1.54 to 3.43). There were no signifificant differences in status of illness or MD for mild-moderate AD patients at 24 weeks (MD: 0.62

95% CI:–2.99 to 4.23) and 48 weeks (MD:–0.73

95% CI:–5.02 to 3.56). Severe AD patients were also assessed at 24 weeks (MD: 3.13

95% CI:–6.92 to 13.18) and 48 weeks (MD: 4.23

95% CI:–6.38 to 14.84). Furthermore

compared with donepezil

Xin (Heart)-regulating CM and Shen (Kidney)-tonifying groups were observed (MD:–1.50

95% CI:–3.08 to 0.08; MD:–1.92

95% CI:–3.50 to–0.33; respectively). CM had fewer side effects in AD patients. Compared with donepezil

oral CM showed no signifificant difference in effectiveness in AD patients

and more evidence is needed to verify the fifindings.

Abstract

To evaluate the effificacy of oral Chinese medicine (CM) in comparison with donepezil

a cholinesterase inhibitor (ChEI)

for the treatment of Alzheimer's disease (AD). Randomized controlled trials (RCTs) have been searched

and the effect of CM compared with donepezil in AD has been investigated. An electronic search of MEDLINE

Excerpta Medica Database (EMBASE)

Cochrane Library

Chinese Biological Medicine Database (CBMdisc)

and China National Knowledge Infrastructure (CNKI) to identify articles in English and Chinese from the inception of the database until October 18

2015. A modifified Jadad score (7-points) to judge the methodological quality of studies

comprehensive meta-analysis was performed with Cochrane Collaboration Revman 5.3. Dichotomous data were analyzed by relative risk (RR) with a 95% confifidence interval (CI)

95% CI:–0.17 to 1.56) and Activities of Daily Living (ADL) scale (MD: 0.94

95% CI:–1.54 to 3.43). There were no signifificant differences in status of illness or MD for mild-moderate AD patients at 24 weeks (MD: 0.62

95% CI:–2.99 to 4.23) and 48 weeks (MD:–0.73

95% CI:–5.02 to 3.56). Severe AD patients were also assessed at 24 weeks (MD: 3.13

95% CI:–6.92 to 13.18) and 48 weeks (MD: 4.23

95% CI:–6.38 to 14.84). Furthermore

compared with donepezil

Xin (Heart)-regulating CM and Shen (Kidney)-tonifying groups were observed (MD:–1.50

95% CI:–3.08 to 0.08; MD:–1.92

95% CI:–3.50 to–0.33; respectively). CM had fewer side effects in AD patients. Compared with donepezil

oral CM showed no signifificant difference in effectiveness in AD patients

and more evidence is needed to verify the fifindings.

关键词

Alzheimer's diseasedonepezilChinese Medicinemeta-analysisrandomized controlled trials

Keywords

Alzheimer's diseasedonepezilChinese Medicinemeta-analysisrandomized controlled trials

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Department of Pharmacy, Zhujiang Hospital of Southern Medical University

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Guang’anmen Hospital, China Academy of Chinese Medical Sciences

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China Academy of Chinese Medical Sciences

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