Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis*

Chi ZHANG; Li LI; Ge ZHANG; Ke-ji CHEN; Ai-ping LU

doi:10.1007/s11655-018-2571-8

Your Location：

Home >

Browse articles >

Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis*

Academic Exploration | Updated：2021-09-01

- Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis*
- Chinese Journal of Integrative Medicine Vol. 27, Issue 6, Pages: 465-469(2021)
- Affiliations：
  
  1.Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing (100700), China
  2.Institute for Advancing Translational Medicine in Bone and Joint Diseases, Hong Kong Baptist University, Hong Kong SAR, China
  3.Cardiovascular Disease Centre, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
- Author bio：
  
  Prof. LU Ai-ping, E-mail: aipinglu@hkbu.edu.hk
- Funds：
- DOI：10.1007/s11655-018-2571-8
  CLC：
- Published：01 June 2021，
  
  Published Online：19 October 2018，
  
  Accepted：09 January 2017
Scan for full text
Chi ZHANG, Li LI, Ge ZHANG, et al. Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis*. [J]. Chinese Journal of Integrative Medicine 27(6):465-469(2021)
DOI：

Chi ZHANG, Li LI, Ge ZHANG, et al. Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis*. [J]. Chinese Journal of Integrative Medicine 27(6):465-469(2021) DOI： 10.1007/s11655-018-2571-8.

摘要

Abstract

Biological complexity and the need for personalized medicine means that biomarker development has become increasingly challenging. Thus

new paradigms for research need to be created that bring together a different classifier of individuals. One potential solution is collaboration between biomarker development and Chinese medicine pattern classification. In this article

two examples of rheumatoid arthritis are discussed

including a new biomarker candidate casein kinase 2 interacting protein 1 (CKIP-1) and a micro RNA 214. The authors obtained a "snapshot" of pattern classification with disease in biomarker identification. Bioinformatics analyses revealed underlying biological functions of two biomarker candidates

in varying degrees

are correlated with Chinese medicine pattern of rheumatoid arthritis. The authors' initial attempt can provide a new window for studying the win-win potential correlation between the biomarkers and pattern classification in Chinese medicine.

关键词

Keywords

Chinese medicine pattern classificationbiomarkerrheumatoid arthritis

references

MR Trusheim, ER Berndt, FL Douglas. Stratified medicine:strategic and economic implications of combining drugs and clinical biomarkers. Nat Rev Drug Discov 2007;6:287-293.

B Freidlin, LM McShane, EL Korn. Randomized clinical trials with biomarkers: design issues. J Natl Cancer Inst 2010;102:152-160.

DH Roukos. Next-generation, genome sequencing-based biomarkers: concerns and challenges for medical practice.Biomark Med 2010;4:583-586.

PD Wagner, M Verma, S Srivastava. Challenges for biomarkers in cancer detection. Ann NY Acad Sci 2004;1022:9-16.

SJ Mandrekar, DJ Sargent. Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges. J Clin Oncol 2009;27:4027-4034.

K Bensalah, F Montorsi, SF Shariat. Challenges of cancer biomarker profiling. Eur Urol 2007;52:1601-1609.

C Zhang, M Jiang, G Zhang, ZX Bian, AP Lu. Progress and perspectives of biomarker discovery in Chinese medicine research. Chin J Integr Med 2014;20:1-9.

M Jiang, C Lu, C Zhang, J Yang, Y Tan, A Lu, et al.Syndrome differentiation in modern research of traditional Chinese medicine. J Ethnopharmacol 2012;140:634-642.

A Lu, M Jiang, C Zhang, K Chan. An integrative approach of linking traditional Chinese medicine pattern classification and biomedicine diagnosis. J Ethnopharmacol 2012;141:549-556.

C Zhang, G Zhang, KJ Chen, AP Lu. Integration of Chinese medicine with Western medicine could lead to future medicine: molecular module medicine. Chin J Integr Med 2016;22:243-250.

M Jiang, J Yang, C Zhang, B Liu, K Chan, H Cao, et al.Clinical studies with traditional Chinese medicine in the past decade and future research and development. Planta Med 2010;76:2048-2064.

C Zhang, M Jiang, XJ He, AP Lu. Clinical trials of integrative medicine for rheumatoid arthritis: Issues and recommendations. Chin J Integr Med 2015;21:403-407.

M Jiang, Q Zha, C Zhang, C Lu, X Yan, W Zhu, et al.Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial. Sci Reports 2015;5:9700.

C Lu, X Niu, C Xiao, G Chen, Q Zha, H Guo, et al. Network-based gene expression biomarkers for cold and heat patterns of rheumatoid arthritis in traditional Chinese medicine. Evid Based Complement Alternat Med 2012;2012:203043.

B Guo, B Zhang, L Zheng, T Tang, J Liu, H Wu, et al.Therapeutic RNA interference targeting CKIP-1 with a cross-species sequence to stimulate bone formation. Bone 2014;59:76-88.

D Li, J Liu, B Guo, C Liang, L Dang, C Lu, et al. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nat Commun 2016;7:10872.

X Wang, B Guo, Q Li, J Peng, Z Yang, A Wang, et al.miR-214 targets ATF4 to inhibit bone formation. Nat Med 2013;19:93-100.

L Zhao, C Xiao, X Yan, J Wang, Y Zhang, Q Li, et al.Correlation between heat or cold syndrome and cytokine, and laboratory index in women with early rheumatoid arthritis. Acta Univ Tradit Med Sinens Pharmacol Shanghai(Chin) 2006;20:21-24.

Y Sun, Q Zhong, X Yao, S Liang, J Liu, K Xie. A meta analysis on the correlation between cold syndrome, heat syndrome and inlfammation index in patients with rheumatoid arthritis. Rheunat Arthrit 2016;5:27-31.

G Maciocia.Diagnosis in Chinese medicine: A comprehensive guide. New York: Churchill Livingstone; 2003:27-28.

JL Tang. Research priorities in traditional Chinese medicine. BMJ 2006;333:391-394.

G Zheng, H Guo, Y Guo, X He, Z Li, A Lu. Two dimensions data slicing algorithm, a new approach in mining rules of literature in traditional Chinese medicine. Communications Computer Inform Sci 2011;237:161-174.

More>

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

Mechanism of Gentisic Acid on Rheumatoid Arthritis Based on miR-19b-3p/RAF1 Axis

Prevalence and Factors Associated with Concomitant Chinese Medicine Use by Rheumatoid Arthritis Patients in A Multi-Ethnic Asian Population

Inokosterone Is a Potential Drug Target of Estrogen Receptor 1 in Rheumatoid Arthritis Patients:Analysis from Active Ingredient of Cyathula Officinalis

Chinese Herbal Formula Ermiao Powder (二妙散) Regulates Cholinergic Anti-inflammatory Pathway in Rats with Rheumatoid Arthritis

Related Author

No data

Related Institution

Department of Orthopaedics, The First Hospital of Hunan University of Chinese Medicine

College of Pharmacy, Hunan University of Chinese Medicine

Department of Traditional Chinese Medicine, Zunyi Medical and Pharmaceutical College

Centre for Quantitative Medicine, Duke-NUS Medical School

Medicine Academic Clinical Program, Division of Medicine, Singapore General Hospital

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰