Chinese Medicine Shensong Yangxin Capsule (参松养心胶囊)Ameliorates Myocardial Microcirculation Dysfunction in Rabbits with Chronic Myocardial Infarction

Chan JIANG; Xi WANG; Song DANG; Xin WANG; Qing DENG; Juan HU; Cong-xin HUANG

doi:10.1007/s11655-018-2578-1

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Chinese Medicine Shensong Yangxin Capsule (参松养心胶囊)Ameliorates Myocardial Microcirculation Dysfunction in Rabbits with Chronic Myocardial Infarction

Original Article | Updated：2021-08-16

- Chinese Medicine Shensong Yangxin Capsule (参松养心胶囊)Ameliorates Myocardial Microcirculation Dysfunction in Rabbits with Chronic Myocardial Infarction
- Chinese Journal of Integrative Medicine Vol. 27, Issue 1, Pages: 24-30(2021)
- Affiliations：
  
  1.Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan (430061), China
  2.Cardiovascular Research Institute of Wuhan University, Wuhan (430061), China
- Author bio：
  
  Correspondence to: Dr. WANG Xi, E-mail: xiwangwhu@163.com
- Funds：
- DOI：10.1007/s11655-018-2578-1
  CLC：
- Published：01 January 2021，
  
  Published Online：09 January 2019，
  
  Accepted：09 October 2017
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Chan JIANG, Xi WANG, Song DANG, et al. Chinese Medicine Shensong Yangxin Capsule (参松养心胶囊)Ameliorates Myocardial Microcirculation Dysfunction in Rabbits with Chronic Myocardial Infarction. [J]. Chinese Journal of Integrative Medicine 27(1):24-30(2021)
DOI：

Chan JIANG, Xi WANG, Song DANG, et al. Chinese Medicine Shensong Yangxin Capsule (参松养心胶囊)Ameliorates Myocardial Microcirculation Dysfunction in Rabbits with Chronic Myocardial Infarction. [J]. Chinese Journal of Integrative Medicine 27(1):24-30(2021) DOI： 10.1007/s11655-018-2578-1.

摘要

Abstract

Objective:

To investigate the effect of Chinese compound Shensong Yangxin Capsule (参松养心胶囊

SSYX) on myocardial microcirculation in myocardial-infarcted rabbits.

Methods:

Myocardial infarction (MI) was established in rabbits by ligation of the left circumflex coronary. Thirty rabbits were randomly divided into the control group

the MI group (model)

and the MI treated with SSYX group (MI+SSYX) by a random number table method. After 4 weeks of administration

low-energy real-time myocardial contrast echocardiography (RT-MCE) was conducted to assess the microcirculatory perfusion. Immunofluorescence double staining was used to detect the capillary density. The endothelial ultrastructure was observed with a transmission electron microscope. The mRNA expression levels of vascular endothelial growth factor (VEGF)

endothelin 1 (ET-1)

prostaglandin I2 (PGI2) and endothelial nitric oxide synthase (eNOS) were measured by real-time quantitative polymerase chain reaction (Real-time PCR). The plasmic levels of ET-1

thromboxane A2 (TXA2)

nitric oxide (NO) and von willebrand factor (vWF) were examined with enzyme-linked immunosorbent assays (ELISA).

Results:

SSYX significantly improved the myocardial blood volume

myocardial micro bubble velocity

and myocardial inflow according to the examination of RT-MCE

and it visibly ameliorated the capillary endothelial structure. Furthermore

compared with the MI group

the plasma levels of TXA2

ET-1 and vWF contents significantly decreased in the MI+SSYX group

and the ET-1 mRNA expression levels of myocardium in the border zone significantly decreased

and the VEGF

PGI2 and eNOS mRNA expression levels significantly increased (all

0.05).

Conclusions:

SSYX has favorable advantages in ameliorating the impaired myocardial microcirculation following MI. The mechanisms of the effect are related to the ability of SSYX in balancing the endothelial-derived vasodilators and vasoconstrictors

and up-regulating the expression of VEGF and eNOS.

关键词

Keywords

myocardial infarctionmicrocirculationendotheliumangiogenesisShensong Yangxin Capsule

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Graduate School of Traditional Chinese Medicine, Beijing University of Chinese Medicine

Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences

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Medical Department, Shanghai Green Valley Pharmaceutical Co., Ltd.

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