Objective:

2

To evaluate the effect of Zhizhu Kuanzhong Capsules (枳术宽中胶囊

ZKC) for functional dyspepsia (FD) through meta-analysis.

Methods:

2

Online databases

including PubMed

EM base

China National Knowledge Infrastructure

Wanfang Data

VIP database and Cochrane Library

were searched for randomized controlled trials (RCTs) of ZKC for FD from the inception to April

2016. Trials were selected according to inclusion criteria and were evaluated with quality assessment standards in the Cochrane Handbook for Systematic Reviews of Interventions and Jadad scale. RevMan 5.3 and GRADEprofiler 3.6 were used for statistical analysis and evidence quality assessment.

Results:

2

Twenty-three trials with 2

496 patients were included and most of them were of poor methodological quality. ZKC alone or ZKC combined with routine Western medicine (WM) showed a better clinical effect rate compared with the control group of WM [odds ratio (OR)=3.32

95% confidence interval (2.66

4.15)

P

<

0.00001]. No serious adverse reactions were reported.

Conclusions:

2

ZKC alone or ZKC combined with routine WM could significantly improve the clinical effective rate in the treatment of FD. The quality of the evidence is low

so it is necessary to design multicenter

strictly randomized and double-blind controlled trials with large samples to validate the conclusions.