Herb-Induced Liver Injury: A Global Concern

Neil Kaplowitz

doi:10.1007/s11655-018-3004-4

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Herb-Induced Liver Injury: A Global Concern

Updated：2021-08-27

- Herb-Induced Liver Injury: A Global Concern
- Chinese Journal of Integrative Medicine Vol. 24, Issue 9, Pages: 643-644(2018)
- Affiliations：
  
  USC Research Center for Liver Disease, USC Keck School of Medicine,Los Angeles,USA
- Author bio：
- Funds：
- DOI：10.1007/s11655-018-3004-4
  CLC：
- Published：2018，
  
  Published Online：3 May 2018，
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Kaplowitz, N. Herb-Induced Liver Injury: A Global Concern., Chin. J. Integr. Med. 24, 643–644 (2018). https://doi.org/10.1007/s11655-018-3004-4

Neil Kaplowitz. Herb-Induced Liver Injury: A Global Concern. [J]. Chinese Journal of Integrative Medicine 24(9):643-644(2018)
Kaplowitz, N. Herb-Induced Liver Injury: A Global Concern., Chin. J. Integr. Med. 24, 643–644 (2018). https://doi.org/10.1007/s11655-018-3004-4 DOI：

Neil Kaplowitz. Herb-Induced Liver Injury: A Global Concern. [J]. Chinese Journal of Integrative Medicine 24(9):643-644(2018) DOI： 10.1007/s11655-018-3004-4.

摘要

Chinese medicine and herb medicine though used to treat liver diseases are an important cause of liver injury. Many phytochemicals have the potential to injure the liver

some in a dose-related fashion and more often in an idiosyncratic fashion

meaning occurrence is uncommon to rare in the population using these treatments. As is the case with pharmaceuticals

the phytochemicals are usually tolerated despite either no or mild transient subclinical injury but rarely in some susceptible patients cause moderate to severe liver injury which is likely mediated by the adaptive immune system.

Abstract

Chinese medicine and herb medicine though used to treat liver diseases are an important cause of liver injury. Many phytochemicals have the potential to injure the liver

some in a dose-related fashion and more often in an idiosyncratic fashion

meaning occurrence is uncommon to rare in the population using these treatments. As is the case with pharmaceuticals

关键词

herb-induced liver injurydiagnosis and managementguidelineChinese Medicine

Keywords

herb-induced liver injurydiagnosis and managementguidelineChinese Medicine

references

Wang JB, Zhu Y, Bai ZF, Wang FS, Li XH, Xiao XH, et al. Guidelines for the diagnosis and management of herb-induced liver injury. Chin J Integr Med 2018;24:696–706.

Favreau JT, Ryu ML, Braunstein G, Orshansky G, Park SS, Coody GL, et al. Severe hepatotoxicity associated with the dietary supplement LipoKinetix. Ann Intern Med 2006;136:590–595.

Fong TL, Klontz KC, Canas–Coto A, Casper SJ, Durazo FA, Davern TJ 2nd, et al. Hepatotoxicity due to hydroxycut: a case series. Am J Gastroenterol 2010;105:1561–1566.

Roytman MM, Pörzgen P, Lee CL, Huddleston L, Kuo TT, Bryant–Greenwood P, et al. Outbreak of severe hepatitis linked to weight–loss supplement OxyELITE Pro. Am J Gastroenterol 2002;109:1296–1298.

Larrey D, Vial T, Pauwels A, Castot A, Biour M, David M, et al. Hepatitis after germander (Teucriumchamaedrys) administration: another instance of herbal medicine hepatotoxicity. Ann Intern Med 1992;117:129–132.

Russmann S, Lauterburg BH, Helbling A. Kava hepatotoxicity. Ann Intern 2001;135:68–69.

Dara L, Liu ZX, Kaplowitz N. Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int 2016; 36:158–165.

WöllS, Kim SH, Greten HJ. Animal plant warfare and secondary metabolite evolution. Nat Prod Bioprospect 2013;3:1–7.

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