Plants are known to possess plenty of pharmacological activities as a result of various phytoconstituents. Tetramethylpyrazine (TMP)

one of the most widely used medicinal compound isolated from traditional Chinese herb

is usually employed for anti-oxidation

anti-inflammation

anti-platelet aggregation

antilipid

anti-fibrosis

as well as activating blood

removing stasis

dilating small arteries

improving microcirculation and antagonizing calcium. In the present paper

the anti-adhesion effect of TMP were reviewed. TMP was found to play a multi-target and muti-link role in anti-adhesion by inhibiting hyperplasia of collagen and overexpression of adhesion-related factors and reducing the concentration of white blood cells and fibrin in plasma. Because previous studies mostly focused on

in vitro

experiments and animal experiments

there is an urgent need for clinical research with abundant indicators to further prove its anti-adhesion potency. Future basic research should concentrate on the development of TMP as a biological material.