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Strategies and Research Progress of Chinese Medicine in Prevention and Treatment of Diabetic Peripheral Neuropathy
- Chinese Journal of Integrative Medicine Vol. 24, Issue 10, Pages: 794-800(2018)
- Affiliations：
Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Translational Medicine Center, Chinese Academy of Medical Sciences,Beijing,China
- Author bio：
- Funds：Supported by the National Natural Science Foundation of China (No. 81473639)
DOI：10.1007/s11655-018-3051-x
CLC：Published：2018，
Published Online：29 September 2018，
Scan for full text
Yang, D., Liang, Xc. Strategies and Research Progress of Chinese Medicine in Prevention and Treatment of Diabetic Peripheral Neuropathy., Chin. J. Integr. Med. 24, 794–800 (2018). https://doi.org/10.1007/s11655-018-3051-x
Dan Yang, Xiao-chun Liang. Strategies and Research Progress of Chinese Medicine in Prevention and Treatment of Diabetic Peripheral Neuropathy. [J]. Chinese Journal of Integrative Medicine 24(10):794-800(2018)
Yang, D., Liang, Xc. Strategies and Research Progress of Chinese Medicine in Prevention and Treatment of Diabetic Peripheral Neuropathy., Chin. J. Integr. Med. 24, 794–800 (2018). https://doi.org/10.1007/s11655-018-3051-x DOI：
Dan Yang, Xiao-chun Liang. Strategies and Research Progress of Chinese Medicine in Prevention and Treatment of Diabetic Peripheral Neuropathy. [J]. Chinese Journal of Integrative Medicine 24(10):794-800(2018) DOI： 10.1007/s11655-018-3051-x.
摘要
Diabetic peripheral neuropathy (DPN) seriously affects the quality of life in patients with type 2 diabetes mellitus. This paper reviews the role of Chinese medicine in the main treatment goal of DPN
including protecting pancreatic β-cells
in the use of antioxidation therapy to delay disease progression
and in the endpoint of neural repair and regeneration. We propose that protecting the body from injury caused by high glucose and oxidative stress
and promoting repair and regeneration of nerves should be the research direction for the prevention and treatment of DPN.
Abstract
Diabetic peripheral neuropathy (DPN) seriously affects the quality of life in patients with type 2 diabetes mellitus. This paper reviews the role of Chinese medicine in the main treatment goal of DPN
including protecting pancreatic β-cells
in the use of antioxidation therapy to delay disease progression
and in the endpoint of neural repair and regeneration. We propose that protecting the body from injury caused by high glucose and oxidative stress
and promoting repair and regeneration of nerves should be the research direction for the prevention and treatment of DPN.
关键词
diabetic peripheral neuropathypancreatic β-cellanti-oxidative stressneural repair and regenerationChinese Medicine
Keywords
diabetic peripheral neuropathypancreatic β-cellanti-oxidative stressneural repair and regenerationChinese Medicine
references
UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphony lureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837–853.
UK Prospective Diabetes Study Group. Overview of 6 years’ therapy of type II diabetes: a progressive disease: UKPDS 16. Diabetes 1995;44:1249–1258.
Dungan KM, Buse JB. Glucagon-like peptide 1-basedtherapies for type 2 diabetes: a focus on exenatide. Clin Diabetes 2005;23:56–62.
Deacon CF, Ahren B, Holst JJ. Inhibitors of dipeptidyl peptidase ?: a novel approach for the prevention and treatment of type 2 diabetes. Expert Opin Investig Drugs 2004;13:1091–1102.
Ahren B, Simonsson E, Larsson H, Landin-Olsson M, Torgeirsson H, Jansson P, et al. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes. Diabetes Care 2002;25:869–875.
Gutierrez RM, Mitchell S, Solis RV. Psidium guajava: a review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 2008;117:1–27.
Cai J, Zhao ZG, Zhang LS, Zhang MY, Dong LN, Qin YJ. Effect of Jinlida Granule on serum nesfatin-1 level and islet ßcell function in patients with pre-diabetes. Chin J Diffic Compl Cas (Chin) 2017;16:720–723.
Wang YZ, Wang HC, Li CH, Sun XH, Wang XX. Influences of Chinese herbal remedies combined with insulin pump on islet ßcell function and insulin resistance in patients with type 2 diabetes. J Beijing Univ Tradit Chin Med (Chin) 2010;33:134–137.
Yu CZ, Kang XD, Dang XJ, Liu CQ. Effect of Modified Liujunzi Decoction on syndrome of Spleen deficiency and phlegh stagnation in patients with type 2 diabetes mellitus. Chin J Inform Tradit Chin Med (Chin) 2017;24:36–39.
Wu Y, Zhao JD. Clinical observation of the effect of Compound Shengjin Granule on β cell function and resistin in patients with qi and yin deficiency type 2 diabetes. Anhui Med Pharmaceut J (Chin) 2016;20:1192–1194.
Zhu LQ, Liu YH, Huang M, Wei H. Study on improvement of islet β cell function in patients with latent autoimmune diabetes mellitus in adults by integrative Chinese and Western medicine. Chin J Integr Tradit West Med (Chin) 2004;24:581–584.
Li H, Xie CG, Zhu TM. Effects of Shenqi Compound on apoptosis and inducible nitric oxide synthase expression in islets β cells of GKrats. Lishizhen Med Mater Med Res (Chin) 2008;19:166–167.
Liu SN, Sun SJ, Liu Q, Hou SC, Shen ZF. Effect of Mudan Granule on islets β cell function in monosodium glutamate induced obese mice with insulin resistance: an experimental study. Chin J Integr Tradit West Med (Chin) 2014;34:853–858.
Song FY, Jia DL, Zhou JY, Chen XY. Effects of Xiaoketing on expression of apoptosis and related genes bcl-2 and Fas in islet β cell. Chin J Informat Tradit Chin Med (Chin) 2001;8:24–26.
Tang SM, Yang ZM, Chen WQ, Yang QF, Chen SY, Li HZ. Astragalus polysaccharide improves type 2 diabetes mellitus in rats by protecting islet β cells. Acad J Sec Milit Med Univ (Chin) 2017;38:482–487.
Chen W, Li YM, Yu MH. Astragalus polysaccharides influence ultrastructure of islets and Th1/Th2 cytokine gene expression of pancrease in NOD mice. Chin J Endocrinol Metabol (Chin) 2007;23:269–271.
Ye KH, Wang JR, Ma JJ, Wang XK, Zhang XQ, Ye WC, et al. Effects and mechanisms of vitexin against ulcerative colitis in mice. Chin Pharm Bull (Chin) 2014;30:1681–1687.
He XX, Su N, Wu XR. Research progress of hypoglycemic effective parts and hypoglycemic activity of mulberry leaves. Chin J Exp Tradit Med Form (Chin) 2014;20:245–247.
Mu XY, Li XJ. Influence of Mori Folium total flavonoid on β cells in rats with type 2 diabetic mellitus. Chin J Exp Tradit Med Form (Chin) 2013;19:213–216.
Sun Y, Deng YR, Wang Y, Lian LL. Research progress in chemical constituents and pharmacological activities of Potentilla discolor Bge. Chin Tradit Patent Med (Chin) 2016;38:639–643.
Su SZ, Xiang DY, Meng FW, Zhang QD. Flavonoids from Potentilla discolor Bunge playing a protective and mechanical role for the type 2 diabetic rats islet cell. Glob Tradit Chin Med (Chin) 2016;9:145–147.
Gong HL, Li WP, Yin YY, Li WZ. Hypoglycemic activity and mechanism of polygona-polysaccharose on diabetic rat model. China J Chin Mater Med (Chin) 2009;34:1149–1154.
Wu S, Lu FE, Dong H, Zhao Y, Xu LJ, Yang MW, et al. Effect of berberine on the pancreatic β cell apoptosis in rats with insulin resistance. Chin J Integr Tradit West Med (Chin) 2011;31:1383–1388.
Ju LJ, Wen XH, Shu L. Study on protective effects of salidrosides on pancreatic β cell survival. J Nanjing Univ Tradit Chin Med (Chin) 2016;32:456–459.
Zhang HL, Ma X. Inhibitory effects of Salvia miltiorrhiza Bge. f. alba water extract on apoptosis of islet β cells in rats. J Sichuan Univ (Natural Sci Ed, Chin) 2017;54:1342–1344.
Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001;414:813–820.
Vincent AM, Callaghan BC, Smith AL, Feldman EL. Diabetic neuropathy: cellular mechanisms as therapeutic targets. Nat Rev Neurol 2011;7:573–583.
Ametov AS, Barinov A, Dyck PJ, Hermann R, Kozlova N, Litchy WJ, et al. The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial. Diabetes Care 2003;26:770–776.
Bertolotto F, Massone A. Combination of alpha lipoic acid and superoxide dismutase leads to physiological and symptomatic improvements in diabetic neuropathy. Drugs R D 2012;12:29–34.
Ziegler D, Low PA, Litchy WJ, Boulton AJM, Ninik AI, Freeman R, et al. Efficacy and safety of antioxidant treatment with a-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care 2011;34:2054–2060.
Papanas N, Maltezos E. α-Lipoic acid, diabetic neuropathy, and Nathan’s prophecy. Angiology 2012;63:81–83.
Ye RQ, Chen ZQ, He YL, Li YH. Protective effects of taurine on diabetic peripheral neuropathy in diabetic rats. Chin J Contemp Neurol Neurosurg (Chin) 2006;6:128–133.
Liang XC, Cui LY, Guo SS, Zhang KJ, Hao WX, Jia L, et al. Clinical study of Jinmaitong Composita on diabetic peripheral neuropathy. Chin J Integr Tradit West Med (Chin) 2001;7:103–106.
Zhang KJ, Liang XC, Cui LY, Guo SS, Hao WX, Jia L, et al. Effects of Jinmaitong Capsule on activity of Na+-K+-ATPase in the patient of lesion of peripheral nerves due to Diabetes. J Tradit Chin Med (Chin) 2001;42:159–161.
Sun Q, Liang XC, Wang PY, Li BW, Zhao L, Huang WZ, et al. Effect of Jinmaitong Capsule on inducible nitric oxide synthase and nitrotyrosine in diabetic rats. China J Chin Mater Med (Chin) 2012;37:348–352.
Zhao L, Liang XC, Zhang H, Wang PY, Sun Q, Huang WZ, et al. Effects of Chinese herbal medicine Jinmaitong-medicated serum on inducible nitric oxide synthase and NADPH oxidase p22-phox subunit of rat Schwann cells cultured in high-glucose medium. J Chin Integr Med (Chin) 2011;9:299–305.
Yang D, Liang XC, Shi Y, Sun Q, Liu D, Liu W, et al. Antioxidative and anti-inflammatory effects of cinnamaldehyde on protecting high glucose-induced damage in cultured dorsal root ganglion neurons of rats. Chin J Integr Med 2016;22:19–27.
Sun Q, Liang XC, Zhang H, Shi Y, Zhang Q, Gu B. Effects of Jinmaitong Capsules-medicated serum on oxidative stress and apoptosis of rat dorsal root ganglion neurons cultured in high glucose medium. Chin Tradit Patent Med (Chin) 2013;35:1390–1395.
Shi Y, Liang XC, Zhang H, Sun Q, Wu QL, Qu L. Combination of quercetin, cinnamaldehyde and hirudin protects rat dorsal root ganglion neurons against high glucose-induced injury through Nrf-2/HO-1 activation and NF-?B inhibition. Chin J Integr Med 2017;23:663–671.
Qu L, Zhang H, Gu B, Dai W, Wu QL, Sun LQ, et al. Jinmaitong alleviates the diabetic peripheral neuropathy by inducing autophagy. Chin J Integr Med 2016;22:185–192.
Yin DH, Liang XC, Zhao LI, Zhang H, Sun Q, Wang PY, et al. Jinmaitong decreases sciatic nerve DNA oxidative damage and apoptosis in a streptozotocin-induced diabetic rat model. Exp Ther Med 2015;10:778–786.
Ye RQ, Chen ZQ, Xiong LL, Li YH, He YL, Lin GB, et al. Effect of Modified Bugan Decoction on cell apoptosis of dorsal root ganglion in diabetic rats. J Tradit Chin Med Univ Hunan (Chin) 2008;28:44–47.
Li YH, Chen ZQ, Ye RQ, He YL. Effect of Modified Bugan Decoction on the expression of p38 mitogen-activated protein kinase in the dorsal root ganglion of diabetic rats with peripheral nerve lesion. Chin J Clin Rehab (Chin) 2006;10:67–69.
Gao YB, Zhou H, Zhang TJ, Feng XZ, Guan S, Yi WM, et al. Clinical research on patients of diabetic peripheral neuropathy treated with Tangluoning. China J Tradit Chin Med Pharm (Chin) 2013;28:1673–1677.
Li BM, Gao YB, Xia J, Zhang TJ, Zhou H, Zhu ZY, et al. Effects of Tangluoning extract on peripheral nerves oxidative stress and downstream MAPKs signal transduction pathways of rates sufferring from diabetes. J Tradit Chin Med (Chin) 2015;56:694–697.
Zhang TJ, Gong YB, Zhou H, Gao YB, Xie PF, Guan S, et al. Effect of Tangluoning on mitochondrial respiratory chain complexes in dorsal root ganglion of STZ-induced diabetic rats. Beijing J Tradit Chin Med (Chin) 2013;32:621–624.
Ning G, Zhou DJ, Liu W, Xing HL, Zhang W, Zhao YJ, et al. Multicenter, randomized, positive-controlled clinical study for the effects of neurotropin on diabetic neuropathy. Natl Med J China (Chin) 2004;84:1785–1787.
Okada M, Suzuki K, Hidaka T, Shinohara T, Kataharada K, Takada K, et al. Complex regional pain syndrome type? induced by pacemaker implantation,with a good response to steroids and neurotropin. Intern Med 2002;41:498–501.
Lu CY, Zhang SR, Zhao WJ, Cai Z, Zheng GM, Zhao J, et al. Effects of Chinese herbal compound Tangbikang on expression of BDNF protein and BDNF mRNA in sciatic nerve in diabetic rats. Chin J Bas Med Tradit Chin Med (Chin) 2015;21:168–171.
Lu CY, Zhang SR, Xu TH, Sun W, Jia XL, Zhao WJ, et al. Influence of Tangbikang on PI3K/AKT signaling pathway of sciatic nerve in rats with diabetic peripheral neuropathy. China J Tradit Chin Med Pharm (Chin) 2016;31:3710–3713.
Qu L, Liang XC, Wu QL, Sun LQ, Zhao L, Chen XP, et al. Effects of Jinmaitong Capsule on nerve growth factor in diabetic rats. China J Chin Mater Med (Chin) 2008;33:2539–2544.
Shi Y, Liang XC, Wu QL, Sun LQ, Qu L, Zhao L, et al. Effect of Jinmaitong on ciliary neurotrophic factor in sciatic nerves of diabetes mellitus rats. Chin J Integr Med 2013;19:104–112.
Wang PY, Liang XC, Zhang H, Wu QL, Qu L, Zhao L. Effects of Jinmaitong Capsule on expression of ciliary neurotrophic factor in diabetic rats. Chin J Integr Tradit West Med Intens Critic Care (Chin) 2010;51:736–739.
Wu QL, Liang XC, Gao YZ, Qun L, Sun LQ, Zhao L, et al. Effects of Jinmaitong Capsule on the expressions of nerve growth factor receptor p75NTR and TrkA of sciatic nerve in diabetic rats. Beijing J Tradit Chin Med (Chin) 2013;32:548–552.
Qu L, Liang XC, Zhang H, Wu QL, Sun LQ, Gu B, et al. Effect of Jinmaitong with medicated serum on proliferation of rat Schwann cells cultured in high glucose medium. Chin J Integr Med 2008;14:293–297.
Wu QL, Liang XC, Zhang H, Qu L, Sun LQ, Zhao L, et al. Effects of serum containing Jinmaitong Capsule on NF-?B of Schwann cells cultured with high glucose medium. World J Integr Tradit West Med (Chin) 2011;6:478–481.
Sun LQ, Liang XC, Zhang H, Wu QL, Qu L, Zhao L, et al. Effects of medicated serum of Jinmaitong Capsule on proliferation and expression of nerve growth factor in Schwann cells cultured in high glucose. China J Tradit Chin Med Pharm (Chin) 2009;24:1019–1022.
Wang PY, Liang XC, Zhang H, Zhao L. Effect of serum containing Jinmaitong Capsule on rats’ Schwann cell apoptosis induced by high glucose concentration. Chin J Integr Med 2013;19:517–523.
Liu XY, Zhang YY, Zhang JQ, Li Y, Sun AJ, Liu JH. Effect of astragalus, salvia, yam and its compound on apoptosis Schwann cells co-cultured with endothelial cells in high glucose. Pharmacol Clin Chin Mater Med (Chin) 2010;26:41–44.
Wu BS, Wang WJ, Chen WH, Ying J, Wang J, Xi J, et al. Effect of allyl glycoside from herba Rhodiolae on activity and proliferation of cultured Schwann cells under high glucose condition. Chin J Integr Tradit West Med (Chin) 2009;29:153–155.
Fu QY, Xiong LL, Chen ZQ, Huang J, Dai XP. Intervene effects of Modified Bugan Decoction on VEGF expression of sciatic nerve in diabetic neuropathy rats. Chin J Tradit Med Sci Technol (Chin) 2008;15:413–415.
Ye RQ, Chen ZQ, Lin GB, Li YH, He YL, Ling JH, et al. Taurine inhibites Schwann cell apoptosis of sciatic nerve in diabetic rats. Basic Clin Med (Chin) 2007;27:1347–1351.
Wang Y, Liu SN, Shen ZF. Dynamic associations of mitochondria-endoplasmic reticulum in maintenance of pancreatic beta cell homeostasis. Acta Pharm Sinic (Chin) 2017;52:667–672.
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