Impact of Hydroalcoholic Extract of <italic style="font-style: italic">Humulus Lupulus</italic> L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats

Narges Karbalaei; Najmeh Sadeghi; Aliakbar Nekoeian; Ahad Malekzadeh

doi:10.1007/s11655-019-3025-7

Your Location：

Home >

Browse articles >

Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats

Original Article | Updated：2021-08-27

- Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats
- Chinese Journal of Integrative Medicine Vol. 25, Issue 7, Pages: 529-535(2019)
- Affiliations：
  
  1.Department of Physiology, Physiology Research Center, School of Medicine, Medical Sciences University of Shiraz(71348-45794), Iran
  2.Department of Medical Physiology, School of Medicine, Jahrom University of Medical Sciences, Jahrom (74148-44196), Iran
  3.Department of Pharmacology, Pharmacology Research Center, School of Medicine, Medical Sciences University of Shiraz(71348-45794), Iran
  4.Department of Mathematics, K.N. Toosi University of Technology, Tehran (16315-1618), Iran
- Author bio：
  
  Correspondence to: Prof. Najmeh Sadeghi, Tel: 98-54340505, E-mail:nsadeghi@yahoo.com, najmeh.sadeghi@gmail.com
- Funds：
- DOI：10.1007/s11655-019-3025-7
  CLC：
- Published：01 July 2019，
  
  Published Online：27 February 2019，
  
  Accepted：30 August 2016
Scan for full text
Narges Karbalaei, Najmeh Sadeghi, Aliakbar Nekoeian, et al. Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats. [J]. Chinese Journal of Integrative Medicine 25(7):529-535(2019)
DOI：

Narges Karbalaei, Najmeh Sadeghi, Aliakbar Nekoeian, et al. Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats. [J]. Chinese Journal of Integrative Medicine 25(7):529-535(2019) DOI： 10.1007/s11655-019-3025-7.

摘要

Abstract

Objective:

To investigate the impact of

Humulus Lupulus

L. hydroalcoholic extract on the body weights

reproductive organs

sperm quality and hormone levels in male rats.

Methods:

By simple random sampling method

seventy male Sprague-Dawley rats were randomly assigned to 7 groups including control group [distilled water

1 mL/(kg•d)]

Tween 80 group [25% Tween 80 solution

1 mL/(kg•d)]

olive oil group [olive oil

1 mL/(kg•d)]

diethyl stilbestrol (DES) group [DES

100 μg/(kg•body weight)]

H50

H150 and H450 [50

150 and 400 mg/(kg•d) of

Humulus Lupulus

L extract

respectively]. The administration was performed via gavage once daily for 7 weeks. Body and reproductive organs weights including testes

seminal vesicles

epididymis and prostate were weighted and epididymal sperm quality were determined by digital balance. Blood samples were collected and serum free testosterone (T)

luteinizing hormone (LH)

follicle-stimulating hormone (FSH)

and estrogen (E

) levels were measured by rat specific enzyme-linked immunosorbent assay.

Results:

The percentage increase in mean body weights of rats in the DES and H50

H150 and H450 groups decreased significantly compared to olive oil and Tween 80 groups (all

0.05). The weights of seminal vesicle

epididymis and testes in rats receiving H50 were significantly higher than the control group (

0.05 or

0.01). The sperm count in the rats receiving H50 was significantly lower than the control group (

0.05). The sperm motile characteristics of the rats receiving hydroalcoholic extract and DES were significantly lower than those of the control or rats receiving vehicles (all

0.05). In H50

H150

H450 and DES groups

T and LH levels were decreased

and E2 was significantly increased compared to the control (

0.05 or

0.01). The FSH level did not change in all groups (

0.05).

Conclusion:

Humulus Lupulus

L. extract significantly increased the seminal vesicle and testes weights and reduced the sperm motility.

关键词

Keywords

sex organphytoestrogenHumulus Lupulus L.sperm qualitymale rat

references

More>

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Humulus lupulus L. Extract Prevents Ovariectomy-Induced Osteoporosis in Mice and Regulates Activities of Osteoblasts and Osteoclasts

Effect of Anthocleista djalonensis A. Chev Root Extract on Testis of Matured Rats

Related Author

No data

Related Institution

Department of Pharmacognosy, School of Pharmacy, Second Military Medical University

School of Pharmacy, Fujian University of Traditional Chinese Medicine

School of Pharmacy, Zhejiang Chinese Medical University

Department of Biochemistry, University of Port Harcourt

Department of Biological Sciences, Redeemer's University

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰

Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats

DOI：10.1007/s11655-019-3025-7

摘要

Abstract

关键词

Keywords

references