Sinomenine (SIN) is a bioactive alkaloid compound extracted from a Chinese medicinal plant

Sinomenium acutum

. It is a multitarget antitumor natural substance. Various mechanisms have been proposed for the antitumor effects of SIN

such as direct cytotoxicity

induction of apoptosis

sensitization attenuating radiotherapy and chemotherapy

reversal of drug resistance

resistance to distant metastasis

and antiangiogenesis. SIN can be used as a tumor cell killer and an adjuvant to radiotherapy and chemotherapy. However

recent studies are mostly limited to the basic experimental stage; no systematic clinical studies have yet been reported. Therefore

this paper aimed to review the mechanism underlying the antitumor effects of SIN by consulting relevant domestic and foreign studies and to provide a relevant reference for further development

use

and exploration of SIN.