Leonurine: From Gynecologic Medicine to Pleiotropic Agent

Yun-yun LI; Yi-kong LIN; Xin-hua LIU; Li WANG; Min YU; Da-jin LI; Yi-zhun ZHU; Mei-rong DU

doi:10.1007/s11655-019-3453-0

Your Location：

Home >

Browse articles >

Leonurine: From Gynecologic Medicine to Pleiotropic Agent

Review | Updated：2021-08-23

- Leonurine: From Gynecologic Medicine to Pleiotropic Agent
- Chinese Journal of Integrative Medicine Vol. 26, Issue 2, Pages: 152-160(2020)
- Affiliations：
  
  1.NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai (200011), China
  2.Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai (200011), China
  3.Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai (201203), China
  4.State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau SAR, China
- Author bio：
  
  Correspondence to: Prof. DU Mei-rong, Fax: 86-21-63457331, E-mail:dmrlq1973@sina.cn
- Funds：
- DOI：10.1007/s11655-019-3453-0
  CLC：
- Published：01 February 2020，
  
  Published Online：08 May 2019，
  
  Accepted：05 November 2018
Scan for full text
Yun-yun LI, Yi-kong LIN, Xin-hua LIU, et al. Leonurine: From Gynecologic Medicine to Pleiotropic Agent. [J]. Chinese Journal of Integrative Medicine 26(2):152-160(2020)
DOI：

Yun-yun LI, Yi-kong LIN, Xin-hua LIU, et al. Leonurine: From Gynecologic Medicine to Pleiotropic Agent. [J]. Chinese Journal of Integrative Medicine 26(2):152-160(2020) DOI： 10.1007/s11655-019-3453-0.

摘要

Abstract

Leonurus japonicus

Houtt

a Chinese traditional herbal medicine

has been widely used to cure gynecological diseases

such as incomplete abortion and menoxenia. Leonurine

a major active alkaloid compound only be found in

Leonurus japonicus

Houtt

has been successfully extracted and purified. Recent evidence has shown that leonurine can regulate a variety of pathologic processes including oxidative stress

inflammation

fibrosis

apoptosis

and multiple metabolic disorders. Here

we have reviewed the pharmacological actions and biological functions of leonurine

with a focus on the role of leonurine in the amelioration of various pathological processes. Insights into the related signaling pathways and molecular mechanisms have strengthened our understanding on the function of leonurine in the alleviation of multiple pathological states. Our summary of the existing researches should help direct future research into the basic science and clinical applications in related diseases.

关键词

Keywords

leonurineLeonurus japonicus HouttChinese medicineoxidative stressinflammationfibrosisclinical application

references

More>

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Schisandrin B Protects against Ischemic Brain Damage by Regulating PI3K/AKT Signaling in Rats

Polypeptide from Moschus Suppresses Lipopolysaccharide-Induced Inflammation by Inhibiting NF-κ B-ROS/NLRP3 Pathway

Related Author

No data

Related Institution

Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine

Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine

Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine

Department of Integrated Traditional Chinese and Western Medicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine

Department of Gastrointestinal Endoscopy, Affiliated Hospital of Nanjing University of Chinese Medicine

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰