Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic Stress Disorder

Lee Bombi; Muk Choi Gwang; Sur Bongjun

doi:10.1007/s11655-020-2724-4

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Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic Stress Disorder

Original Article | Updated：2021-08-16

- Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic Stress Disorder
- Chinese Journal of Integrative Medicine Vol. 27, Issue 1, Pages: 39-46(2021)
- Affiliations：
  
  1.Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul (02447),Republic of Korea
  2.Center for Converging Humanities,Kyung Hee University, Seoul (02447), Republic of Korea
  3.The Graduate School of Basic Science of Medicine, College of Medicine, Kyung Hee University, Seoul (02447), Republic of Korea
  4.Department of Molecular Medicine and TIDRC, School of Medicine, Ewha Womans University, Seoul (07985), Republic of Korea
- Author bio：
  
  Correspondence to: Dr. Bombi Lee, E-mail: bombi@khu.ac.kr
- Funds：
- DOI：10.1007/s11655-020-2724-4
  CLC：
- Published：01 January 2021，
  
  Published Online：22 May 2020，
  
  Accepted：14 November 2019
Scan for full text
Lee Bombi, Muk Choi Gwang, Sur Bongjun. Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic Stress Disorder. [J]. Chinese Journal of Integrative Medicine 27(1):39-46(2021)
DOI：

Lee Bombi, Muk Choi Gwang, Sur Bongjun. Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic Stress Disorder. [J]. Chinese Journal of Integrative Medicine 27(1):39-46(2021) DOI： 10.1007/s11655-020-2724-4.

摘要

Abstract

Objective:

Post-traumatic stress disorder (PTSD) is a psychiatric disorder characterized by depression and anxiety

that arises due to an imbalance of neurotransmitters in response to excessive stress. Hesperidin (HSD) is a naturally occurring flavonoid shown to exert a variety of biological activities

including antioxidant

anti-inflammatory

and neuroprotective effects.

Methods:

This study was used the open field test (OFT) and forced swimming test (FST) to examine the effects of HSD on the depression-like response of rats after exposure to a single prolonged stress (SPS) leading to the dysregulation of the serotonergic activation system. Male rats were given HSD (20

and 100 mg/kg

intraperitoneal injection

=6–7 per group) once daily for 14 days after exposure to SPS. The influence of administration of HSD on SPS-induced behavioral responses and concentrations of serotonin (5-HT)

5-hydroxyindoleacetic acid (5-HIAA)

and monoamine oxidase-A (MAO-A) in the rat brain were also investigated using enzyme-linked immunoassays (ELISAs).

Results:

Daily HSD administration significantly improved depression-like behaviors in the FST (

0.05)

increased the number of lines crossed in the central zone of the OFT (

0.01)

and reduced freezing behavior both in contextual and cued fear conditioning. HSD treatment also attenuated the reduction in SPS-induced 5-HT concentrations in the hippocampus and amygdala. This increase in 5-HT concentrations during HSD treatment was partially attributed to a decrease in the 5-HIAA/5-HT ratio in the hippocampus of rats with PTSD. Furthermore

HSD treatment inhibited activity of MAO-A and decreases of tryptophan hydroxylase-1 expression in the hippocampus.

Conclusion:

HSD was shown to exert antidepressant effects in rats exposed to SPS

suggesting that this natural flavonoid may be an effective medicine for PTSD.

关键词

Keywords

hesperidinpost-traumatic stress disorderdepressionserotonin

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