Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial

khaton Zare Elmi Halimeh; Gholami Mohammad; Saki Mandana; Ebrahimzadeh Farzad

doi:10.1007/s11655-020-2727-1

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Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial

Original Article | Updated：2021-08-16

- Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial
- Chinese Journal of Integrative Medicine Vol. 27, Issue 1, Pages: 7-15(2021)
- Affiliations：
  
  1.Student Research Committee, Lorestan University of Medical Sciences, Khorramabad (6814993165), Iran
  2.School of Nursing and Midwifery, Lorestan University of Medical Sciences, Khorramabad (6814993165), Iran
  3.Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad (6814993165), Iran
  4.Department of Biostatistics and Epidemiology, School of Health and Nutrition,Lorestan University of Medical Sciences, Khorramabad(6814993165), Iran
- Author bio：
  
  Correspondence to: Dr. Mohammad Gholami, E-Mail:mohammad13565@yahoo.com
- Funds：
- DOI：10.1007/s11655-020-2727-1
  CLC：
- Published：01 January 2021，
  
  Accepted：15 January 2020
Scan for full text
khaton Zare Elmi Halimeh, Gholami Mohammad, Saki Mandana, et al. Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial. [J]. Chinese Journal of Integrative Medicine 27(1):7-15(2021)
DOI：

khaton Zare Elmi Halimeh, Gholami Mohammad, Saki Mandana, et al. Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial. [J]. Chinese Journal of Integrative Medicine 27(1):7-15(2021) DOI： 10.1007/s11655-020-2727-1.

摘要

Abstract

Objective:

To assess the effect of valerian root extract on the sleep quality of patients after coronary artery bypass graft (CABG) surgery.

Methods:

The patients who participated in this triple-blind clinical trial were selected by permuted block randomization. The participants were assigned to the valerian (

=36) and placebo (

=36) groups. The valerian group received 530 mg of valerian capsules for 30 nights after CABG surgery

and the placebo group received 530 mg of the placebo capsules containing wheat flour. The Pittsburgh Sleep Quality Index (PSQI)

the prothrombin time (PT) and partial thromboplastin time (PTT) were assessed on four occasions

including the baseline

the 3rd

14th and 30th days following intervention.

Results:

The odds ratio of worsened sleep quality significantly varied over time (the interaction of time and group) in the valerian group compared to the placebo group in various dimensions including total sleep quality (

=0.001)

sleep latency (

0.01)

sleep duration (

=0.020)

sleep efficiency (

=0.001) and daytime dysfunction (

=0.025). No significant difference was observed in the alterations of the odds ratio of PT in the two groups over time. (

=0.371).

Conclusion:

The consumption of oral valerian root extract over 30 nights could significantly improve the patients' sleep quality safely after CABG surgery.

关键词

Keywords

coronary artery bypass graftherbal medicinerandomized controlled trialsleep qualityvalerian

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