Wake-Promoting Effect of Bloodletting Puncture at Hand Twelve Jing-Well Points in Acute Stroke Patients:A Multi-center Randomized Controlled Trial

Nan-nan YU; Zhi-fang XU; Yang GAO; Zhi-liang ZHOU; Xue ZHAO; Dan ZHOU; Zhen-guo WANG; Ze-lin CHEN; Xing-fang PAN; Yi GUO

doi:10.1007/s11655-020-3093-8

Your Location：

Home >

Browse articles >

Wake-Promoting Effect of Bloodletting Puncture at Hand Twelve Jing-Well Points in Acute Stroke Patients:A Multi-center Randomized Controlled Trial

Acupuncture Research | Updated：2021-09-01

- Wake-Promoting Effect of Bloodletting Puncture at Hand Twelve Jing-Well Points in Acute Stroke Patients:A Multi-center Randomized Controlled Trial
- Chinese Journal of Integrative Medicine Vol. 27, Issue 8, Pages: 570-577(2021)
- Affiliations：
  
  1.Department of Traditional Chinese Medicine, Xijing Hospital, the Air Force Medical University, Xi'an (710032), China
  2.Acupuncture Research Center, Tianjin University of traditional Chinese Medicine, Tianjin (301617), China
  3.Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tianjin (301617), China
  4.Department of Acupuncture and Moxibustion, the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin (300193), China
  5.Department of Acupuncture and Moxibustion, the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin(300150), China
  6.The Third Department of Encephalopathy, Xi'an Encephalopathy Hospital of Traditional Chinese Medicine, Xi'an (710032), China
  7.Department of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin (301617), China
- Author bio：
  
  Associate Prof. PAN Xing-fang, E-mail: panxingfang@163.com
  Prof. GUO Yi, E-mail: guoyi_2016@126.com;
- Funds：
- DOI：10.1007/s11655-020-3093-8
  CLC：
- Published：01 August 2021，
  
  Published Online：11 September 2020，
  
  Accepted：21 October 2019
Scan for full text
Nan-nan YU, Zhi-fang XU, Yang GAO, et al. Wake-Promoting Effect of Bloodletting Puncture at Hand Twelve Jing-Well Points in Acute Stroke Patients:A Multi-center Randomized Controlled Trial. [J]. Chinese Journal of Integrative Medicine 27(8):570-577(2021)
DOI：

Nan-nan YU, Zhi-fang XU, Yang GAO, et al. Wake-Promoting Effect of Bloodletting Puncture at Hand Twelve Jing-Well Points in Acute Stroke Patients:A Multi-center Randomized Controlled Trial. [J]. Chinese Journal of Integrative Medicine 27(8):570-577(2021) DOI： 10.1007/s11655-020-3093-8.

摘要

Abstract

Objective:

To assess the effect and safety of bloodletting puncture at hand twelve Jing-Well points (HTWPs) in acute stroke patients with conscious disturbance.

Methods:

In this multi-center and randomized controlled trial

360 patients suffered from ischemic or hemorrhagic stroke with conscious disturbance within 48 h from the onset of symptom were divided into bloodletting (180 cases) and control (180 cases) groups using a block randomization. Patients in both groups received routine Western medicine

and patients in the bloodletting group received additional bloodletting puncture at HTWPs on admission immediately before conventional treatment. The primary outcome measure was Glasgow Coma Scale (GCS) score and the secondary outcomes included blood pressure

respiratory rate and pulse rate. All variables were evaluated at baseline (before bloodletting)

0 (after bloodletting immediately)

50 and 80 min post bloodletting.

Results:

At 80 min post bloodletting

the proportion of patients with improved consciousness in the bloodletting group was greater than the control group (

0.05). In the separate analysis of moderate consciousness disturbance subgroup

bloodletting therapy benefited ischemic patients

and improved the eye and language response of GCS score at 15

80 min post bloodletting (

0.05 or

0.01). No significant differences were observed regarding the secondary outcomes between two groups (

0.05).

Conclusion:

The bloodletting puncture at HTWPs was safe and could improve conscious levels of ischemic stroke patients

highlighting a first-aid intervention for acute stroke. (Registration No. ChiCTR-INR-16009530)

关键词

Keywords

acute strokebloodlettingJing-Well pointconscious disturbancerandomized controlled trialGlasgow Coma Scale

references

Donnan GA, Fisher M, Macleod M, Davis SM. Stroke.Lancet 2008;371:1612-1623.

Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics—2015 update: a report from the American Heart Association.Circulation 2015;131:e329-e322.

Liu M, Wu B, Wang WZ, Lee LM, Zhang SH, Kong LZ. Stroke in China: epidemiology, prevention, and management strategies. Lancet Neurol 2007;6:456-464.

Tsao JW, Hemphill JC 3rd, Johnston SC, Smith WS, Bonovich DC. Initial Glasgow Coma Scale score predicts outcome following thrombolysis for posterior circulation stroke. Arch Neurol 2005;62:1126-1129.

Voetsch B, DeWitt LD, Pessin MS, Caplan LR. Basilar artery occlusive disease in the New England Medical Center Posterior Circulation Registry. Arch Neurol 2004;61:496-504.

Braga P, Ibarra A, Rega I, Ketzoian C, Pebet M, Servente L, et al. Prediction of early mortality after acute stroke. J Stroke Cerebrovasc Dis 2002;11:15-22.

Grond M, Rudolf J, Schmulling S, Stenzel C, Neveling M, Heiss WD. Early intravenous thrombolysis with recombinant tissue-type plasminogen activator in vertebrobasilar ischemic stroke. Arch Neurol 1998;55:466-469.

Chen C, Ye M, Chen BL, Chen GF, Gao ZQ, Zhou JS, et al.Thrombolysis on ischemic stroke patients with decreased level of consciousness within 4.5 h. CNS Neurosci Ther 2013;19:48-52.

Mulder MJ, van Oostenbrugge RJ, Dippel DW. Letter by Mulder et al regarding article, "2015 AHA/ASA focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: a guideline for healthcare professionals from the American Heart Association/American Stroke Association".Stroke 2015;4:e235.

Morris DL, Rosamond W, Madden K, Schultz C, Hamilton S.Prehospital and emergency department delays after acute stroke: the genentech stroke presentation survey. Stroke 2000;31:2585-2590.

Chang KC, Tseng MC, Tan TY. Prehospital delay after acute stroke in Kaohsiung, Taiwan. Stroke 2004;35:700-704.

Katzan IL, Hammer MD, Furlan AJ, Hixson ED, Nadzam DM. Quality improvement and tissue-type plasminogen activator for acute ischemic stroke: a Cleveland update.Stroke 2003;34:799-800.

Reed SD, Cramer SC, Blough DK, Meyer K, Jarvik JG.Treatment with tissue plasminogen activator and inpatient mortality rates for patients with ischemic stroke treated in community hospitals. Stroke 2001;32:1832-1840.

Johnston SC, Fung LH, Gillum LA, Smith WS, Brass LM, Lichtman JH, et al. Utilization of intravenous tissue-type plasminogen activator for ischemic stroke at academic medical centers: the influence of ethnicity. Stroke 2001;32:1061-1068.

Wang DZ, Rose JA, Honings DS, Garwacki DJ, Milbrandt JC. Treating acute stroke patients with intravenous tPA.The OSF stroke network experience. Stroke 2000;31:77-81.

Perez de la Ossa N, Davalos A. Neuroprotection in cerebral infarction: the opportunity of new studies. Cerebrovas Dis 2007;24(Suppl 1):153-156.

Cheng K, Law A, Guo M, Wieland LS, Shen X, Lao L.Acupuncture for acute hordeolum. Cochrane Database Syst Rev 2017;2:CD011075-CD011075.

Chang QY, Lin YW, Hsieh CL. Acupuncture and neuroregeneration in ischemic stroke. Neural Regen Res 2018;13:573-583.

Zhang M, Hu QL, Cheng SX, Tu Y, Zhang S. Comparative study on the brain protection in patients of traumatic cerebral infarction treated with bloodletting at Jing-Well points and Semen coicis. Chin Acupunct Moxibust (Chin)2013;33:779-783.

Miao XM, Cheng SX, Yang Z, Zhang S, Han WJ, Tu Y, et al.Therapeutic bloodletting at Jing-Well points combine hypothermia attenuated acute cerebral edema after traumatic brain injury in rats. Chin J Appl Physiol (Chin) 2015;31:249-253.

Tu Y, Miao XM, Yi TL, Chen XY, Sun HT, Cheng SX, et al. Neuroprotective effects of bloodletting at Jing points combined with mild induced hypothermia in acute severe traumatic brain injury. Neural Regen Res 2016;11:931-936.

Fu Y, Li Y, Guo J, Liu B, Liu H, Zhang W, et al. Bloodletting at Jing-Well points decreases interstitial fluid flow in the thalamus of rats. J Tradit Chin Med 2016;36:107-112.

Gao L, Chen Z, Tian L, Li Z, Guo Y. Effects of bloodletting puncture at Jing-Well points in distal ends of finger and toe on survival rate and brain edema in cerebral ischemic rats.J Tradit Chin Med 2012;32:471-476.

Guo Y, Wang XY, Xu TP, Dai ZH, Li YC. Effect of blood-letting puncture at twelve well-points of hand on consciousness and heart rate in patients with apoplexy. J Tradit Chin Med 2005;25:85-89.

Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet 1974;2:81-84.

Ding J, Guo Y. Effect of pricking blood at twelve Jing points of hand on state of consciousness in the patient of early stroke. Chin Acupunct Moxibust (Chin) 2004;24:11-14.

Roberts I, Yates D, Sandercock P, Farrell B, Wasserberg J, Lomas G, et al. Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 2004;364:1321-1328.

Vickers AJ. Parametric versus non-parametric statistics in the analysis of randomized trials with non-normally distributed data. BMC Med Res Methodol 2005;5:35.

Yue Y, Pan X, Zhang S, Jin J, Wang W, Wang D, et al. A randomized controlled trial of puncturing and bloodletting at twelve hand Jing points to treat acute carbon monoxide poisoning as adjunct to first aid treatment: a study protocol.Evid Based Complement Alternat Med 2015;2015:827305.

Jin J, Zhang S, Li HY, Han DX, Jiang R, Ding SS, et al.Effect of twelve Well points of the hand pricking blood therapy on acute carbon monoxide poisoning state of consciousness in patients with disorders of consciousness.J Emerg Tradit Chin Med (Chin) 2012;21:175-176.

Gamez D. The measurement of consciousness: a framework for the scientific study of consciousness. Front Psychol 2014;5:714.

Gao DQ, Su YY, Zhang YZ, Lin W, Ran G, Zhao JW.Predicting the prognosis in patients with acute stroke accompanied with conscious disturbance with different coma scales. Chin J Cerebrovasc Dis (Chin) 2009;6:620-625.

Hifumi T, Kuroda Y, Kawakita K, Sawano H, Tahara Y, Hase M, et al. Effect of admission Glasgow Coma Scale Motor Score on neurological outcome in out-of-hospital cardiac arrest patients receiving therapeutic hypothermia.Circ J 2015;79:2201-2208.

Acker SN, Ross JT, Partrick DA, Nadlonek NA, Bronsert M, Bensard DD. Glasgow motor scale alone is equivalent to Glasgow Coma Scale at identifying children at risk for serious traumatic brain injury. J Trauma Acute Care Surg 2014;77:304-309.

Lei J, Wang L, Gao G, Cooper E, Jiang J. Right median nerve electrical stimulation for acute traumatic coma patients. J Neurotrauma 2015;32:1584-1589.

Vithoulkas G, Muresanu DF. Conscience and consciousness: a definition. J Med Life 2014;7:104-108.

Saper CB, Chou TC, Scammell TE. The sleep switch:hypothalamic control of sleep and wakefulness. Trends Neurosci 2001;24:726-731.

Ciurleo R, Bramanti P, Calabro RS. Pharmacotherapy for disorders of consciousness: are 'awakening' drugs really a possibility? Drugs 2013;73:1849-1862.

Liu JT, Wang CH, Chou IC, Sun SS, Koa CH, Cooper E.Regaining consciousness for prolonged comatose patients with right median nerve stimulation. Acta Neurochir Suppl 2003;87:11-14.

Cooper EB, Scherder EJ, Cooper JB. Electrical treatment of reduced consciousness: experience with coma and Alzheimer's disease. Neuropsychol Rehabil 2005;15:389-405.

Yu N, Wang Z, Chen Y, Yang J, Lu X, Guo Y, et al. The ameliorative effect of bloodletting puncture at hand twelve Jing-Well points on cerebral edema induced by permanent middle cerebral ischemia via protecting the tight junctions of the bloodbrain barrier. BMC Complement Altern Med 2017;17:470.

More>

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Immediate Effect of Electro-acupuncture on Endometrial Blood Flow in Patients with Recurrent Implantation Failure:A Randomized Controlled Trial

Factors and Their Impact on Treatment Effect of Acupuncture in Different Outcomes: A Meta-Regression of Acupuncture Randomized Controlled Trials

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy: A Multicenter Double-Blind Randomized Controlled Trial

Effectiveness of Zhenqi Buxue Oral Liquid Combined with Progesterone for Treatment of Oligomenorrhea and Hypomenorrhea with Qi-Blood and Kidney (Shen)Essence Deficiency: A Randomized Controlled Trial

Acupuncture for Patients with Chronic Spontaneous Urticaria:A Randomized, Sham-Controlled Pilot Trial

Related Author

No data

Related Institution

Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine

Sichuan Jinxin Xi'nan Women's and Children's Hospital

Yuan TCM Wellness Pte. Ltd.

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences

China Center for Evidence-Based Traditional Chinese Medicine, China Academy of Chinese Medical Sciences

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰