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Effectiveness and Safety of Umbilicus Treatment with Modified Dinggui Powder (加味丁桂散) in Patients with Chronic Nonbacterial Prostatitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
- Chinese Journal of Integrative Medicine Vol. 27, Issue 3, Pages: 170-176(2021)
- Affiliations：
1.Department of Joint Surgery, Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai (200052), China
2.Department of Vascular Surgery, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai (200082), China
3.Department of Urology and Andrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai(200032), China
4.Shanghai Qigong Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai(200030), China
5.School of Acupuncture-Moxbustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai (201203), China
- Author bio：
Correspondence to: Prof. YING Jian, E-mail: yingjian03@sina.com
- Funds：
DOI：10.1007/s11655-020-3258-5
CLC：Published：01 March 2021，
Published Online：20 April 2020，
Accepted：27 February 2019
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Hai HUANG, Min-jie ZHOU, Ke-xie WANG, et al. Effectiveness and Safety of Umbilicus Treatment with Modified Dinggui Powder (加味丁桂散) in Patients with Chronic Nonbacterial Prostatitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. [J]. Chinese Journal of Integrative Medicine 27(3):170-176(2021)
Hai HUANG, Min-jie ZHOU, Ke-xie WANG, et al. Effectiveness and Safety of Umbilicus Treatment with Modified Dinggui Powder (加味丁桂散) in Patients with Chronic Nonbacterial Prostatitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. [J]. Chinese Journal of Integrative Medicine 27(3):170-176(2021) DOI： 10.1007/s11655-020-3258-5.
摘要
Abstract
Objective:
2
To evaluate the effectiveness and safety of Chinese herbal external umbilicus treatment with Modified Dinggui Powder (加味丁桂散
MDGP) in patients with chronic nonbacterial prostatitis (CNP).
Methods:
2
A randomized
double-blind
placebo-controlled clinical trial was conducted among 72 patients with CNP. Participants were randomly allocated to a treatment group and a placebo group using computer software in a 1:1 ratio
and received either MDGP external umbilicus treatment (MDGP group
36 cases) or placebo (control group
36 cases) at acupoints Shenque (CV 8)
twice a week for 4 weeks. In addtion
patients all received herbal medicine treatment twice a day for 4 weeks. The primary outcome was the US National Institutes of Health Chronic Prostatitis Symptom Scores Index (NIH-CPSI) with a questionnaire at weeks 2 and 4. The secondary outcomes including prostatic fluid examination (white blood cells and lecithin bodies)
the clinical efficacy evaluation
and the adverse events were also assessed during the entire trial.
Results:
2
The NIH-CPSI scores regarding pain or discomfort scores showed greater improvement in the MDGP group than placebo control group at weeks 2 (
P
=0.001) and week 4 (
P
=0.004)
respectively. NIH-CPSI scores of symptom severity
total scores and leukocytes number in the prostatic fluid in the MDGP group were significantly improved (
P
<
0.05). There was no statistical difference in the urinary symptoms
quality of life
lecithin and other scores between two groups (
P
>
0.05). The clinical effective rate was 73.53% (25/34) in the MDGP group
which was significally higher than the placebo control group with 48.39% (25/31
P
<
0.05). Patients were blinded successfully
and no serious adverse effects were found during the trial.
Conclusion:
2
A 4-week course of umbilicus treatment with modified Dinggui Powder seems to relieve pain and symptom severity effectively and increase the amount of leukocytes number in patients with CNP (Trial registration No. ChiCTR1800014687).
关键词
Keywords
Modified Dinggui Powderumbilicus treatmentchronic nonbacterial prostatitisrandomizedplacebo-controlled trial
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