Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke

Wen-jie HAO; Bing-jie LI; Xiao-lei WU; Zhen-bo CHEN; Xin ZHANG; Han YAO; Wen-yan ZHANG; Xue-gong FENG

doi:10.1007/s11655-020-3325-y

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Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke

Clinical Experience | Updated：2021-09-01

- Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke
- Chinese Journal of Integrative Medicine Vol. 27, Issue 5, Pages: 369-374(2021)
- Affiliations：
  
  1.Department of Encephalopathy, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing (100039), China
  2.Department of Neurology, China Rehabilitation Research Center, Beijing (100068), China
  3.Department of Radiology, China Rehabilitation Research Center, Beijing(100068), China
  4.The 3rd Department of Neurorehabilitation, China Rehabilitation Research Center, Beijing (100068), China
- Author bio：
  
  Prof. FENG Xue-gong, E-mail: bjcwhfxg@sina.com
- Funds：
- DOI：10.1007/s11655-020-3325-y
  CLC：
- Published：01 May 2021，
  
  Published Online：30 September 2020，
  
  Accepted：26 April 2020
Scan for full text
Wen-jie HAO, Bing-jie LI, Xiao-lei WU, et al. Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke. [J]. Chinese Journal of Integrative Medicine 27(5):369-374(2021)
DOI：

Wen-jie HAO, Bing-jie LI, Xiao-lei WU, et al. Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke. [J]. Chinese Journal of Integrative Medicine 27(5):369-374(2021) DOI： 10.1007/s11655-020-3325-y.

摘要

Abstract

Objective:

To observe the effects and safety of Tongyan Spray (通咽喷雾剂) on the range and time of hyoid motion in patients with ischemic post-stroke dysphagia.

Methods:

Seventy-two patients with ischemic post-stroke dysphagia were selected and randomly assigned to a treatment group (36 cases) and a control group (36 cases) by a random number table from January 2013 to October 2014. All patients swallowed 4 kinds of barium meals with different traits respectively

and each patient underwent video fluoroscopy (VF) examination twice. In the treatment group

Tongyan Spray was sprayed to the pharynx on both sides and the middle part once respectively. The spray was applied 30 min before the second examination. Purified water at room temperature was used as placebo in the control group. The changes in the range and time of hyoid motion in both groups were observed before and after treatment.

Results:

Six patients dropped out in each group

and 60 patients completed the study and were included in the final analysis. Significant improvement was observed in the range of superior hyoid excursion distance and the time of hyoid motion in the treatment group compared with the control group (

0.05). There were no obvious adverse reactions observed in oral mucosa in both groups during the whole study.

Conclusion:

Tongyan Spray was an effective and safe medicine for improving swallowing function in patients with ischemic post-stroke dysphagia.

关键词

Keywords

Tongyan Spraystrokedysphagiahyoid motionvideo fluoroscopyChinese medicine

references

M Gonzalez-Fernandez, L Ottenstein, L Atanelov, A Christian. Dysphagia after stroke: an overview. Curr Phys Med Rehabi Rep 2013;1:187-196.

PU Heuschmann, PL Kolominisky-Rabas, B Misselwitz, P Hermanek, C Leffmann, R Janzen, et al. Predictors of in-hospital mortality and attributable risks of death after ischemic stroke: the German Stroke Registers Study Group. Arch Intern Med 2004;164:1761-1768.

JA Hinchey, T Shephard, K Furie, D Smith, D Wang, S Tonn.Formal dysphagia screening protocols prevent pneumonia.Stroke 2005;36:1972-1976.

DK Nan, ed. Rehabilitation medicine. Beijing: People's Medical Publishing House;2004:11-12.

J Yang. Efficacy analysis on acupuncture combined with intermediate frequency electric stimulator in the treatment of 60 patients with post-stroke dysphagia. Chin J Pract Nerv Dis (Chin) 2013;16:75-76.

DM Zhang, XR Zhang. Clinical observation of post-stroke dysphagia treated by pharyngeal stimulation with lemon ice swab. Chin J Clin Med (Chin) 2010;23:254-255.

XG Feng, WJ Hao, Z Ding, Q Sui, H Guo, J Fu. Clinical randomized controlled study on Tongyan Spray for post-stroke dysphagia patients. Chin J Integr Med 2012;18:345-349.

RD Wilson, EC Howe. A cost-effectiveness analysis of screening methods for dysphagia after stroke. PM R 2012;4:273-282.

SM Sisodiya, JM Stevens, DR Fish, SL Free, SD Shorvon.The demonstration of gyral abnormalities in patients with cryptogenic partial epilepsy using three-dimensional MRI.Arch Neurol 1996;53:28-34.

E Schober, W Schima, P Pokieser. Radiologic assessment of globus pharyngis. Comparison of the diagnostic value of conventional roentgen with videocinematography.Radiologe 1995;35:724-732.

Chinese Society of Neurology. The key points for diagnosis of different cerebrovascular diseases. Chin J Neurol (Chin)1996;29:379.

The Encephalopathic Emergency Cooperation Group of the State Administration of Traditional Chinese Medicine.The diagnosis and curative effect assessment standard for stroke. J Beijing Univ Tradit Chin Med (Chin) 1996;19:55-56.

BJ Li, T Zhang, BH Wang. Study of hyoid motion during swallowing in normal elder. Chin J Rehabil Theory Pract(Chin) 2004;10:774-775.

BJ Li, T Zhang, BH Wang. Video fluroscopy swallow study in healthy older women. Chin J Geriatr (Chin) 2004;23:796-799.

X Zhang, W Wang, H Zhang. Imaging swallowing dysfunction among patients recovering from severe traumatic brain injury. Chin J Phys Med Rehabil (Chin) 2012;34:573-578.

SY Zheng. Comparative study between the ginger application by Zhongjing and the modern pharmacology and application of gingers. Strait Pharm J (Chin) 2002;14:94-95.

HT Fu, JS Meng, Y Sun, YX Tian, HZ Yang, N Jiang, et al.Effect of atomization inhalation of Weilingxian Decoction on dysphagia in patients with ischemic stroke at recovery stage of pseudobulbar paralysis. Chin J Thrombos Hemostas(Chin) 2018;24:946-947.

KY Luo, YJ Qiang, HQ Gao. Research progress on chemical constituents and pharmacological effects of Clematis chinensis. J Gansu Coll Tradit Chin Med (Chin)2015;32:60-63.

FR Zhu, YN Li, SL He, QS Chen, XY Xu. Cytotoxic activities of total saponins from Plena Clematis on human tumor cell lines in vitro. Chin J Integr Med 2018;24:763-767.

K Yabunaka, H Sanada, S Sanada, H Konishi, T Hashimoto, H Yatake, et al. Sonographic assessment of hyoid bone movement during swallowing: a study of normal adults with advancing age. Radiol Phys Technol 2011;4:73-77.

Y Kim, GH Mccullough. Maximum hyoid displacement in normal swallowing. Dysphagia 2008;23:274-279.

N Ueda, K Nohara, Y Kotani, N Tanaka, K Okuno, T Sakai.Effects of the bolus volume on hyoid movements in normal individuals. J Oral Rehabil 2013;40:491-499.

J Zhang, Y Zhou, N Wei, B Yang, AX Wang, H Zhou, et al. Laryngeal elevation velocity and aspiration in acute ischemic stroke patients. PLoS One 2016;11:e0162257.

EC Ward, K Green, AL Morton. Patterns and predictors of swallowing resolution following adult traumatic brain injury.J Head Trauma Rehabil 2007;22:184-191.

IJ Cook, WJ Dodds, RO Dantas, MK Kern, BT Massey, R Shaker, et al. Timing of videofluoroscopic, manometric events, and bolus transit during the oral and pharyngeal phases of swallowing. Dysphagia 1989;4:8-15.

P Jacob, PJ Kahrilas, JA Logtmann, V Shah, T Ha. Upper esophageal sphincter opening and modulation during swallowing. Gastroenterology 1989;97:1469-1478.

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Department of Rehabilitation Medicine, Dapeng New District Nan'ao People's Hospital

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Neurology Department, Xinhua Hospital of Zhejiang Province

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