Effect of Oral Chinese Medicine Combined with Western Medicine on Cancer Pain: A Meta-Analysis

Yao-han WANG; Jin-yuan CHANG; Li FENG

doi:10.1007/s11655-020-3423-x

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Effect of Oral Chinese Medicine Combined with Western Medicine on Cancer Pain: A Meta-Analysis

Evidence-Based Integrative Medicine | Updated：2021-09-01

- Effect of Oral Chinese Medicine Combined with Western Medicine on Cancer Pain: A Meta-Analysis
- Chinese Journal of Integrative Medicine Vol. 27, Issue 9, Pages: 713-720(2021)
- Affiliations：
  
  1.Traditional Chinese Medicine Department, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing(100021), China
  2.China Academy of Chinese Medical Sciences, Beijing(100700), China
  3.Depatment of Oncology, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing(10039), China
- Author bio：
  
  Prof. FENG Li, E-mail: fengli663@126. com
- Funds：
- DOI：10.1007/s11655-020-3423-x
  CLC：
- Published：01 September 2021，
  
  Published Online：19 August 2020，
  
  Accepted：21 February 2020
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Yao-han WANG, Jin-yuan CHANG, Li FENG. Effect of Oral Chinese Medicine Combined with Western Medicine on Cancer Pain: A Meta-Analysis. [J]. Chinese Journal of Integrative Medicine 27(9):713-720(2021)
DOI：

Yao-han WANG, Jin-yuan CHANG, Li FENG. Effect of Oral Chinese Medicine Combined with Western Medicine on Cancer Pain: A Meta-Analysis. [J]. Chinese Journal of Integrative Medicine 27(9):713-720(2021) DOI： 10.1007/s11655-020-3423-x.

摘要

Abstract

Objective:

To assess the effect of oral Chinese medicine (OCM) combined with Western medicine (WM) on cancer pain.

Methods:

PubMed

Embase

Cochrane Library

Clinical Trials Registry Platform

Chinese National Knowledge Infrastructure (CNKI)

Wanfang and VIP databases were searched from their inception to September 2019. Randomized controlled trials (RCTs) treating cancer pain by Chinese medicine (CM) combined with WM were included. The primary outcome were total pain relief rate and the quality of life (QOL)

and the other outcomes were the average daily dosage of analgesics

the primary time of pain

the analgesic duration time

and adverse events. The methodological quality of RCTs was assessed in accordance with Cochrane 5.1.0 handbook of systematic reviews of interventions. Evidence level was assessed by the Grades of Recommendation

Assessment

Development and Evaluation (GRADE) approach.

Results:

There were 1

087 patients in the 14 studies

with 544 in the experiment group and 543 in the control group. These studies were all conducted in China

and published between 2006 and 2019. Compared with the WM

OCM combined with WM could significantly relieve the cancer pain [risk ratio (RR)=1.43

95% confidence interval (CI): 1.32

1.56)

improve QOL (RR=8.57

95% CI: 4.25

12.89)

decrease the primary time of pain (RR=–0.20

95% CI: –0.24

–0.16]

prolong the analgesic duration time (RR=3.47

95% CI: 2.09

4.85)

reduce the dosage of analgesics (RR=–19.52

95% CI: –36.32

–2.72)

and reduce side events (RR=0.49

95% CI: 0.37

0.65). Evidence levels for total pain relief rate

primary time of pain and side events were low

evidence level for QOL

analgesic duration time and average daily dosage of analgesics were very low.

Conclusions:

Compared with the WM

OCM combined with WM could significantly relieve the cancer pain

improve the QOL

decrease the primary time of pain

prolong the analgesic duration time

reduce the dosage of analgesics and side events. The evidence levels were low or very low.

关键词

Keywords

oral Chinese medicinecancer painclinical trialmeta-analysis

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