Changes of Anti-tuberculosis Herbs Formula during Past Three Decades in Contrast to Ancient Ones*

Yu-hui XU; Dai Guang-ming; Shi-huan TANG; Hong-jun YANG; Zhao-gang SUN

doi:10.1007/s11655-020-3475-y

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Changes of Anti-tuberculosis Herbs Formula during Past Three Decades in Contrast to Ancient Ones*

Literature Research | Updated：2021-09-01

- Changes of Anti-tuberculosis Herbs Formula during Past Three Decades in Contrast to Ancient Ones*
- Chinese Journal of Integrative Medicine Vol. 27, Issue 5, Pages: 388-393(2021)
- Affiliations：
  
  1.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (100700), China
  2.Translational Medicine Center, Beijing Chest Hospital, Capital Medical University, Beijing (101149), China
  3.Beijing Key Laboratory in Drug Resistant Tuberculosis Research, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing (101149), China
- Author bio：
  
  Prof. SUN Zhao-gang, E-mail:sunzg75@163.com
- Funds：
- DOI：10.1007/s11655-020-3475-y
  CLC：
- Published：01 May 2021，
  
  Published Online：09 July 2020，
  
  Accepted：17 April 2019
Scan for full text
Yu-hui XU, Dai Guang-ming, Shi-huan TANG, et al. Changes of Anti-tuberculosis Herbs Formula during Past Three Decades in Contrast to Ancient Ones*. [J]. Chinese Journal of Integrative Medicine 27(5):388-393(2021)
DOI：

Yu-hui XU, Dai Guang-ming, Shi-huan TANG, et al. Changes of Anti-tuberculosis Herbs Formula during Past Three Decades in Contrast to Ancient Ones*. [J]. Chinese Journal of Integrative Medicine 27(5):388-393(2021) DOI： 10.1007/s11655-020-3475-y.

摘要

Abstract

Objective:

To investigate the evolution of herbal medicine in treating tuberculosis (TB) and encourage anti-TB drug discovery and development.

Methods:

In this study

477 ancient traditional Chinese medicine formulae were collected from the Dictionary of Traditional Chinese Medicine Prescriptions and 172 modern Chinese medicine formulae (from 1986 to 2016) were collected by searching 4 databases: WanFang Data Knowledge Service Platform

China National Knowledge Infrastructure Database (CNKI)

China Science and Technology Journal Database (VIP) and Chinese Bio-medical Literature and Retrieval System (SinoMed) in Chinese. We restricted the search to publications in Chinese. Further data analysis was done using the Traditional Chinese Medicine Inheritance Support System version 2 Software.

Results:

There were 425 herbs in the 477 ancient formulae and 257 herbs in the 172 modern formulae. Half of the top 30 herbs were shared by both modern and ancient prescriptions. They are

Radix Ophiopogonis

Astragalus membranaceus

Fritillaria cirrhosa

Dried rehmannia glutinosa

Poria cocos

Angelica sinensis

Prepared rehmannia glutinosa

Platycodon Root

Radix paeoniae alba

Schisandra chinensis

Bighead atractylodes rhizome

Rhizoma anemarrhenae

Cortex lycii radicis and Radix Scutellariae

. Only two groups of herbs with a high correlation coefficient were found in both modern and ancient prescriptions

the

Dried rehmannia glutinosa

with Radix ophiopogonis

and

Radix ophiopogonis

with

Prepared rehmannia glutinosa

. There were 9 and 15 core herb combinations in modern and ancient prescriptions

respectively

but no one was found simutaniously in both modern and ancient prescriptions.

Conclusions:

Although there were wide variations in the herb groups and herb combinations in the formulae

half of the top 30 herbs were found in both modern and ancient prescriptions. The core herb combinations in modern and ancient prescriptions could help us to improve the priscription for treatment of TB.

关键词

Keywords

herbal formulatuberculosisChinese materia medicaanti-tuberculosis herbs

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