Effect of Danhong Injection (丹红注射液) on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention*

Qing-rong LIU; Hong-xu LIU; Wen-long XING; Qi ZHOU; Hong-liang ZHANG; Hai-tong ZHANG; Guang-yuan SONG; Yong-jian WU

doi:10.1007/s11655-021-2853-4

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Effect of Danhong Injection (丹红注射液) on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention*

Clinical Experience | Updated：2021-09-01

- Effect of Danhong Injection (丹红注射液) on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention*
- Chinese Journal of Integrative Medicine Vol. 27, Issue 6, Pages: 455-460(2021)
- Affiliations：
  
  1.Department of Cardiology, Fuwai Hospital of Chinese Academy of Medical Sciences, Beijing (100037), China
  2.Key Laboratory of Cellular Physiology, Ministry of Education (Shanxi Medical University), and the Department of Physiology, Shanxi Medical University, Taiyuan (030001), China
  3.Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing (100010), China
- Author bio：
  
  Prof. WU Yong-jian, E-mail: yongjianwu_nccd@163.com
- Funds：
- DOI：10.1007/s11655-021-2853-4
  CLC：
- Published：01 June 2021，
  
  Published Online：12 January 2021，
  
  Accepted：22 September 2018
Scan for full text
Qing-rong LIU, Hong-xu LIU, Wen-long XING, et al. Effect of Danhong Injection (丹红注射液) on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention*. [J]. Chinese Journal of Integrative Medicine 27(6):455-460(2021)
DOI：

Qing-rong LIU, Hong-xu LIU, Wen-long XING, et al. Effect of Danhong Injection (丹红注射液) on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention*. [J]. Chinese Journal of Integrative Medicine 27(6):455-460(2021) DOI： 10.1007/s11655-021-2853-4.

摘要

Abstract

Objective:

To explore the effectiveness of Danhong Injection (丹红注射液) on improving microcirculatory injury after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD).

Methods:

A randomized controlled trial was conducted and 90 patients were enrolled. A random sequence was generated using statistical analysis software. Patients with microcirculatory injuries after PCI were randomly divided into 3 groups for treatment (30 subjects in each group): Danhong Injection group: after PCI

Danghong Injections were given with intravenous administration with 40 mL twice a day for a week; statins intensive group: after PCI

atorvastatin calcium tablets were given oral medication with 80 mg once

and then atorvastatin 40 mg daily for 1 week; the control group: after PCI

atorvastatin calcium tablets were given oral medication with 10–20 mg daily for 1 week. The index of microcirculation resistance (IMR) was used to assess microcirculatory injury during PCI. The IMR of the target vessel was reexamined after 1 week of drug treatment.

Results:

After one week's drug treatment

IMR was significantly decreased in both statins intensive group and Danhong Injection group compared with the control group (

0.01)

but no difference was found between statins intensive group and Danhong injection group (14.03±2.54 vs. 16.03±5.72 U

=0.080).

Conclusions:

The efficacy of Danhong Injection is non-inferior to statin. Early use of Danhong Injection after PCI can effectively improve coronary microcirculation injury after PCI.

关键词

Keywords

Danhong Injectioncoronary arteryinterventional therapycoronary microcirculation injuryChinese medicine

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