Mechanism of 'Invigorating Qi and Promoting Blood Circulation'Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology

Gao-jie XIN; Yu-wei ZHAO; Ling-mei LI; Fei-fan JIA; Xiao HAN; Lei LI; Hao GUO; Hong-xu MENG; Jian-hua FU; Jian-xun LIU

doi:10.1007/s11655-021-2859-y

Your Location：

Home >

Browse articles >

Mechanism of 'Invigorating Qi and Promoting Blood Circulation'Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology

Original Article | Updated：2021-09-01

- Mechanism of 'Invigorating Qi and Promoting Blood Circulation'Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology
- Chinese Journal of Integrative Medicine Vol. 27, Issue 6, Pages: 440-445(2021)
- Affiliations：
  
  1.Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Pharmacology of Chinese Materia, Beijing (100091), China
  2.National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
- Author bio：
  
  Prof. FU Jian-hua, E-mail:jianhuaffcn@263.net
- Funds：
- DOI：10.1007/s11655-021-2859-y
  CLC：
- Published：01 June 2021，
  
  Published Online：09 January 2021，
  
  Accepted：25 August 2020
Scan for full text
Gao-jie XIN, Yu-wei ZHAO, Ling-mei LI, et al. Mechanism of 'Invigorating Qi and Promoting Blood Circulation'Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology. [J]. Chinese Journal of Integrative Medicine 27(6):440-445(2021)
DOI：

Gao-jie XIN, Yu-wei ZHAO, Ling-mei LI, et al. Mechanism of 'Invigorating Qi and Promoting Blood Circulation'Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology. [J]. Chinese Journal of Integrative Medicine 27(6):440-445(2021) DOI： 10.1007/s11655-021-2859-y.

摘要

Abstract

Objective:

Using network pharmacology to explore the mechanism of the 'invigorating qi and promoting blood circulation' drug pair Ginseng-Danshen (

Salvia miltiorrhiza

) on treatment of ischemic heart disease (IHD).

Methods:

The chemical constituents of ginseng and Danshen drug pair were identified by searching the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP)

and the potential targets of the pair were identified. The pharmacodynamics of the pair was analyzed using network pharmacology. The targets of IHD were identified by database screening. Using protein-protein interaction network

the interaction targets of Ginseng-Danshen on IHD were constructed. A "constituent-target-disease" interaction network was constructed using Cytoscape software

Gene Ontology (GO) term enrichment analysis and biological pathway enrichment analysis were carried out

and the mechanism of improving myocardial ischemia by the Ginseng-Danshen drug pair was investigated.

Results:

Seventeen active constituents and 53 targets were identified from ginseng

53 active constituents and 61 targets were identified from Danshen

and 32 protein targets were shared by ginseng and Danshen. Twenty GO terms were analyzed

including cytokine receptor binding

cytokine activity

heme binding

and antioxidant activity. Sixty Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways were analyzed

including phosphatidylinositol 3-kinase-serine-threonine kinase (PI3K-AKT) signaling pathway

p53 signaling pathway

interleukin 17 signaling pathway

tumor necrosis factor signaling pathway

and the advanced glycation end product (AGE)-the receptor for AGE (RAGE) signaling pathway in diabetic complications.

Conclusion:

The specific mechanism of Ginseng-Danshen drug pair in treating IHD may be associated with improving the changes of metabolites inbody

inhibiting the production of peroxides

removing the endogenous oxygen free radicals

regulating the expression of inflammatory factors

reducing myocardial cell apoptosis and promoting vascular regeneration.

关键词

Keywords

network pharmacologyGinseng-DanshenSalvia miltiorrhizadrug pairischemic heart diseaseinvigorating qi and promoting blood circulation

references

R V Jensen, MV Hjortbak, EB Hans. Ischemic heart disease: an update. Semin Nucl Med 2020;50:195-207.

ZG Wu. Therapeutic angiogenesis: the combination point of Chinese and Western medicine in prevention and treatment of ischemic heart disease. Chin J Integr Med 2009;15:323-324.

DT Wang, L Wang, HJ Yin. Analysis of medication rules of corrective treatment for coronary heart disease of qi-deficiency and blood-stasis syndrome. J Med Res (Chin) 2016;45:66-69.

W Li, PF Lu, D Gao, J Song, KJ Chen. Effect of Xuefu Zhuyu Capsule on angiogenesis in hindlimb ischemic rats. Chin J Integr Med 2020;26:39-45.

FH Li, SW Guo, CG Wang, XL Huang, H Wang, XB Tan, et al. Yiqihuoxue decoction protects against post-myocardial infarction injury via activation of cardiomyocytes PGC-1α expression. BMC Complement Altern Med 2018; 18:253.

YF Tan, J Yu, WJ Pan, JY Qi, MZ Zhang. Protective mechanisms of Suxiao Jiuxin Pills on myocardial ischemia-reperfusion injury in vivo and in vitro. Chin J Integr Med 2020;26:583-590.

YM Zhang, ZY Zhang, RX Wang. Protective mechanisms of quercetin against myocardial ischemia reperfusion injury. Front Physiol 2020;11:956.

YY Jin , H Gao, XY Zhang, H Ai, XL Zhu, J Wang. Shenfu Injection inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock. Chin J Integr Med 2017; 23:170-175.

B Shi, Y Huang, J Ni, J Chen, J Wei, H Gao, et al. Qi Dan Li Xin Pill improves chronic heart failure by regulating mTOR/p70S6k-mediated autophagy and inhibiting apoptosis. Sci Rep 2020;10:6105.

ZC Ji, HY Hu, FW Yang, LS Zhang, XY Jin, HC Wang, et al.Network meta-analysis of Yiqi Huoxue Chinese patent medicine for coronary heart disease with angina pectoris. Chin J Chin Mater Med (Chin) 2019;9:1927-1937.

K Zheng, J Wu, FF Zhang. Study on medication rules of traditional Chinese medicine in the treatment of coronary heart disease based on data mining. Chin Med Herald 2018;36:113-116.

JL Ru, P Li, J Wang, W Zhou, BH Li, C Huang, et al. TCMSP:a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform 2014;6:13.

Q Yang, Y Zhao, Z Zhang, J Chen. Association of interleukin-6 methylation in leukocyte DNA with serum level and the risk of ischemic heart disease. Scand J Clin Lab Invest 2016;76:291-295.

N Makki, KW Thiel, Miller FJJr. The epidermal growth factor receptor and its ligands in cardiovascular disease. Int J Mol Sci 2013;14:20597-20613.

R Ganguly, D Hasanally, A Stamenkovic, TG Maddaford, R Chaudhary, GN Pierce, et al. Alpha linolenic acid decreases apoptosis and oxidized phospholipids in cardiomyocytes during ischemia/reperfusion. Mol Cell Biochem 2018;437:163-175.

YG Wang, YW Yu, G Zheng. Research and strategies on angiogenesis of combined application of ginseng and red sage root in prevention and treatment of coronary heart disease. J Shaanxi Coll Tradit Chin Med (Chin) 2012;35:67-70.

CA Guo, S Guo. Insulin receptor substrate signaling controls cardiac energy metabolism and heart failure. J Endocrinol 2017;233:131-143.

PVM Ribeiro, JF Tavares, MAC Costa, JB Mattar, RCG Alfenas.Effect of reducing dietary advanced glycation end products on obesity-associated complications: a systematic review. Nutr Rev 2019;77:725-734.

JM Bao, MY He, YW Liu, YJ Lu, Y Jiang. AGE/RAGE/Akt pathway contributes to prostate cancer cell proliferation by promoting Rb phosphorylation and degradation. Am J Cancer Res 2015;5:1741.

Z Wu, L Ding, J Bao, Y Liu, Q Zhang, J Wang, et al. Co-infection of Mycoplasma gallisepticum and Escherichia coli triggers inflammatory injury involving the IL-17 signaling pathway. Front Microbiol 2019;15:2615.

More>

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Clean-DM1, a Korean Polyherbal Formula, Improves High Fat Diet-Induced Diabetic Symptoms in Mice by Regulating IRS/PI3K/AKT and AMPK Expressions in Pancreas and Liver Tissues

Monotropein Induced Apoptosis and Suppressed Cell Cycle Progression in Colorectal Cancer Cells

Therapeutic Mechanism of Kai Xin San on Alzheimer's Disease Based on Network Pharmacology and Experimental Validation

Chinese Medicine as Supporting Therapy for Psoriasis:Past, Present, and Future

Network Pharmacology and in vitro Experimental Verification on Intervention of Quercetin, Present in Chinese Medicine Yishen Qutong Granules, on Esophageal Cancer

Related Author

No data

Related Institution

Shanxi Key Laboratory of Traditional Herbal Medicines Processing, Shanxi University of Chinese Medicine

Korean Medicine R&D Center, Dongguk University

College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University

Department of Herbology, College of Korean Medicine, Dongguk University

Department of Gynecology, Hangzhou Women's Hospital

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰