Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis<sup>*</sup>

Qi-qi XIN; Xun CHEN; Rong YUAN; Ya-hui YUAN; Jia-qi HUI; Yu MIAO; Wei-hong CONG; Ke-ji CHEN

doi:10.1007/s11655-021-2871-2

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Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis^*

Evidence-Based Integrative Medicine | Updated：2021-11-05

- Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis^*
- Chinese Journal of Integrative Medicine Vol. 27, Issue 11, Pages: 858-866(2021)
- Affiliations：
  
  1.Laboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
  2.National Clinical Research Center for Chinese Medicine Cardiology, Beijing (100091), China
  3.Department of Clinical Laboratory, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
- Author bio：
  
  Prof. CONG Wei-hong, E-mail: congcao@188.com
- Funds：
- DOI：10.1007/s11655-021-2871-2
  CLC：
- Published：01 November 2021，
  
  Published Online：16 September 2021，
  
  Accepted：18 January 2021
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Qi-qi XIN, Xun CHEN, Rong YUAN, et al. Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis^*. [J]. Chinese Journal of Integrative Medicine 27(11):858-866(2021)
DOI：

Qi-qi XIN, Xun CHEN, Rong YUAN, et al. Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis^*. [J]. Chinese Journal of Integrative Medicine 27(11):858-866(2021) DOI： 10.1007/s11655-021-2871-2.

摘要

目的:

探讨冠心病血瘀证与血小板、凝血功能的相关性.

方法:

本研究方案已于PROSPERO网站注册(CRD42019129452). 检索PubMed、Embase、Cochrane图书馆和中国知网数据库

纳入包含冠心病血瘀证和非血瘀证患者并提供血小板和凝血功能信息的相关研究

检索时间截止到2020年6月1日. 通过森林图比较冠心病血瘀证与非血瘀症患者的血小板功能、凝血功能和纤溶活性差异. 通过亚组分析、敏感性分析以探索异质性的来源.

结果:

共检索出1583篇论文

经过筛选最终纳入30项试验、涉及10323名患者. meta分析结果显示

血瘀证组平均血小板体积、血小板分布宽度、血小板聚集率、P-选择素、纤维蛋白原、纤溶酶原激活物抑制剂-1 (PAI-1)、血栓素B2 (TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)、TXB2/6-keto-PGF1α均高于非血瘀证组(

0.05或

0.01). 在冠心病急性期

血瘀证组活化部分凝血活酶时间低于非血瘀证组(

0.01). 血瘀证组组织纤溶酶原激活物(t-PA)和t-PA/PAI-1、R、K值均低于非血瘀证组(均

0.01). 两组间血小板计数、血小板压积、血栓弹力图最大振幅、血管性血友病因子、凝血酶原时间、凝血酶时间、国际标准化比值等结果无统计学差异.

结论:

与冠心病非血瘀证患者相比

血瘀证患者呈现出血小板功能亢进、高凝、纤溶活性降低的特点.

Abstract

Objective:

To investigate the correlation of platelet and coagulation function with blood stasis syndrome (BSS) in coronary heart disease (CHD).

Methods:

The protocol for this meta-analysis was registered on PROSPERO (CRD42019129452). PubMed

Excerpta Medica Database (Embase)

the Cochrane Library

and China National Knowledge Infrastructure (CNKI) were searched from inception to 1st June

2020. Trials were considered eligible if they enrolled BSS and non-BSS (NBSS) patients with CHD and provided information on platelet and coagulation function. The platelet function

coagulation function

and fibrinolytic activity were compared between the BSS and NBSS groups. Forest plots were generated to show the SMDs or ESs with corresponding 95% CIs for each study. Subgroup analysis and sensitivity analysis were performed to explore potential sources of heterogeneity.

Results:

The systematic search identified 1

583 articles. Thirty trials involving 10

323 patients were included in the meta-analysis. The results showed that mean platelet volume

platelet distribution width

platelet aggregation rate

platelet P selectin

fibrinogen

plasminogen activator inhibitor-1 (PAI-1)

thromboxane B2 (TXB2)

6-keto-prostaglandin F1alpha (6-keto-PGF1α)

and TXB2/6-keto-PGF1α were higher in the BSS group than in the NBSS group (

0.05 or

0.01). Activated partial thromboplastin time was lower in the BSS group than in the NBSS group in the acute phase of CHD (

0.01). The R and K values in thromboelastography and tissue plasminogen activator (t-PA) and t-PA/PAI-1 were lower in the BSS group than in the NBSS group (all

0.01). No difference was found in the results of platelet count

plateletcrit

maximum amplitude

von Willebrand factor

prothrombin time

thrombin time

international normalized ratio

etc. between groups.

Conclusions:

Increased platelet function

hypercoagulability

and decreased fibrinolytic activity were found among CHD patients with BSS.

关键词

Keywords

coronary heart diseaseblood stasis syndromeplateletcoagulation

references

Yu B, Chen K, Mao J. Clinical study on effect of concentrated Xuefu Zhuyu Pill on restenosis of 43 cases coronary heart disease after intracoronary stenting. Chin J Integr Trad West Med (Chin) 1998;18:585-587.

The Academic Committee of Promoting Blood Circulation and Removing Blood Stasis of Chinese Association of Integrative Medicine. Trial criteria for diagnosis of blood stasis syndrome. J Integr Trad West Med (Chin) 1983;3:C2.

The Academic Committee of Promoting Blood Circulation and Removing Blood Stasis of Chinese Association of Integrative Medicine. Diagnostic criteria for blood stasis syndrome. Chin J Integr Trad West Med (Chin) 1987;7:129.

The Academic Committee of Promoting Blood Circulation and Removing Blood Stasis of Chinese Association of Integrative Medicine. Diagnostic criteria for coronary heart disease with blood stasis syndrome. Chin J Integr Trad West Med (Chin) 2016;36:1162.

Deng KX. Correlation between TCM syndromes and coagulation function in unstable angina Pectoris of coronary heart disease [dissertation]. Harbin: Heilongjiang University of Chinese Medicine; 2019.

Wu ZJ, Dong X, Zhao Y, Du XX, Jin J, Liu L. Relationship between blood stasis syndrome and related blood test parameters in coronary heart disease. J Tradit Chin Med Univ Hunan (Chin) 2019;39:230-233.

Yang ZH, Li J, Li P. Correlative study between TCM syndromes of coronary heart disease and red blood cell distribution width and mean platelets volume. Lishizhen Med Mater Med Res (Chin) 2017;28:1691-1693.

Shao AH, Qi X. Clinical research on the changes of coagulation-fibrinolysis system in patients with acute coronary syndrome with blood stasis. Chin J Integr Med Cardiocerebrovasc Dis (Chin) 2016;14:876-878.

Zhang WT, Hu YH, Chu YG, Zhu BC, Shang XY, Wang SH, et al. The research on thrombogenesis graph of coronary atherosclerotic heart disease of different TCM syndromes.World Chin Med (Chin) 2016;11:71-74.

Chu YG, Li J, Song QQ, Wei Y, Zhang WT, Yan F, et al.Correlation study on thromboela-stogram with blood stasis syndrome of TCM in patients with coronary heart diseases.Beijing J Tradit Chin Med (Chin) 2015;34:683-685.

Li L. Correlation between the blood stasis of acute coronary syndrome and the indexes of thrombelastogram [dissertation].Beijing: Beijing University of Chinese Medicine; 2015.

Han B. Study on relationship between different TCM syndromes of coronary heart disease and coronary artery CAG [dissertation]. Jinan: Shandong University of Chinese Medicine; 2014.

Li H. The correlative study between coronary teriography, coagulation indexes and TCM syndrome differentiation-type in unstable angina pectoris [dissertation]. Nanjing: Nanjing University of Chinese Medicine; 2014.

Zhan JH, Zhao SF, Wang JW. Correlation of platelet parameter and coronary heart disease. Liaoning J Tradit Chin Med (Chin) 2014;41:2632-2633.

Zhai XQ, Liu H, Wang XF. Study on the correlation between Chinese medicine syndrome types of the Ulghur and Han people and levels of blood lipids and fibrinogen in premature coronary heart disease patients. Chin J Integr Tradit West Med (Chin) 2012;4:478-481.

Shi Q. Traditional Chinese medicine syndrome identification modes of unstable angina pectoris caused by coronary heart disease based on data mining [dissertation]. Beijing:Beijing University of Chinses Medicine; 2012.

Fu CG. Study on diagnostic criteria of blood stasis syndrome in coronary heart disease [dissertation]. Beijing:Beijing University of Chinese Medicine; 2011.

Wu SL. Relevant study of von willebrand factor and P select element to heart blood stasis syndrome in coronary heart disease [dissertation]. Nanjing: Nanjing University of Chinese Medicine; 2011.

She D, Li CL, Wang QG. Study on the relationship between prethrombotic state of coronary heart disease and TCM syndrome. Guangxi J Tradit Chin Med (Chin) 2010;33:10-12.

He L, Zhou XH, Jin WJ, Wang J, Wang XF, Wu G. Study on correlation of TCM syndrome with blood lipid, and coagulation factors of female coronary heart disease in Xinjiang province. Xinjiang J Tradit Chin Med (Chin)2009;27:41-43.

Xi RX. Study on the traditional Chinese medicine syndromes and physical-biomarkers indexes in acute coronary syndrome patients after PCI [dissertation]. Beijing:China Academy of Chinese Medical Sciences; 2009.

Yao D. Clinical observation of TCM syndrome on 187 cases of coronary heart disease. Liaoning J Tradit Chin Med (Chin)2009;39:930-933.

Yuan ZK, Huang XP, Jian WX, Zheng JH, Li YH, Wang LP, et al. Clinical study on the relationship between syndrome differentiation of coronary heart disease and coagulation-fibrinolytic system. J Yunnan Univ Tradit Chin Med (Chin)2009;32:1-4.

Long WP, Shi L, Wei AH, Yang JY. Study on the correlation of syndrome differentiation of coronary heart disease with endothelial injury, inflammatory response and platelet activation. J Guangzhou Univ Tradit Chin Med (Chin)2008;25:457-460.

Kong SY. Study on the correlation of syndrome differentiation of angina pectoris with Hyc, Fg, Tc, GsH [dissertation].Chengdu: Chengdu University of Chinese Medicine; 2006.

Mao YL, Yuan ZK, Huang XP, Lu FG, Tan GB, Hu ZX. The association of GMP-140, t-PA and PAI-1 levels in the plasma with the pattern of blood stasis of coronary heart disease. J Tradit Chin Med Univ Hunan (Chin) 2004;24:29-31.

Luo LJ. Correlation Between the Syndrome of Coronary Heart Disease and the Contents of CD62p, TXB2 and 6-Keto-PGF1α. Shanghai J Tradit Chin Med (Chin)2002;7:13-14.

Jia BS. Relation of the level of platelet membrane glycoproteins, platelet adhesion, platelet aggregation and traditional Chinese medicine syndrome patterns of coronary heart disease. J Integr Trad West Med (Chin)1989;9:717-719, 707.

Yang SX, Hong XF, Li TD. Comparison of lipoperoxidative damage in plasma and platelet with the ratio of thromboxane A2 and prostaglandin I2 in blood stasis syndrome with coronary heart disease. Chin J Integr Trad West Med (Chin) 1993;13:661-662, 644.

Zhang DM, Chen JH, Zhu MH. Relationship between traditional Chinese medicine syndrome and hemorheology of coronary heart disease. J Fuzhou Gen Hosp (Chin)1999;6:20, 42.

Liu XL, Sun LJ. Correlation of syndrome differentiation with hemorheology and microcirculation in coronary heart disease. Chin J Microcircul (Chin) 1997;7:20-21.

Wang YM, Han CX. Correlation of syndrome differentiation with platelet volume and distribution width in patients with coronary heart disease. Chin J Integr Trad West Med (Chin)1996;16:49.

Guo XC, Ding HY, Qi WH, Gong LS, Shao HZ. Correlation of TCM syndrome differentiation with prostaglandin, platelet function and protein C antigen in coronary heart disease. J Integr Trad West Med (Chin) 1991;11:259, 263-264.

Chen SX, Chang PL, Zheng XJ, Chen MS, Xie XL, Chen MF. Some parameters of blood-stasis, yin deficiency, and yang deficiency in patients with remote myocardial infarction.J Integr Trad West Med (Chin) 1989;9:644-645, 660-662.

Balta S, Demirkol S, Kucuk U, Arslan Z, Unlu M, Lyisoy A, et al. Mean platelet volume may be related to the degree of coronary collateral circulation. Eur Rev Med Pharmacol Sci 2013;17:707-708.

Beyan C, Kaptan K, Ifran A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract 2010;64:827.

Meltem RE, Savas A, Ali Z, Isa S, Yesim G, Umit G, et al.Mean platelet volume: an important predictor of coronary collateral development. Platelets 2013;24:200-204.

Adem B, Muhammed TAO, Erhan T, Emine G, Ali UY, Ahmet T, et al. Increased platelet distribution width is associated with severity of coronary artery disease in patients with acute coronary syndrome. Angiology 2014;66:638-643.

Șeref U, Ahmet K, Zeynettin K, Hüseyin K, Hüseyin Ö, Mustafa B, et al. Association between PDW and long term major adverse cardiac events in patients with acute coronary syndrome. Heart Lung Circ 2016;25:29-34.

Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract 2010;63: 1509-1515.

Ma AD, Abrams CS. Pleckstrin homology domains and phospholipid-induced cytoskeletal reorganization. Thromb Haemost 1999;82:399-406.

Numano F, Aizawa T, Nomura S, Yajima M, Fujii J.Coronary spasm, prostaglandin and HLA factors. Jpn Circ J 1985;49:119-127.

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Department of Cardiology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine

Emergency Department, Xiyuan Hospital of China Academy of Chinese Medical Sciences

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